- Business
- Cellectis SA (Nasdaq:CLLS; Euronext Growth Paris:ALCLS) develops gene-edited allogeneic chimeric antigen receptor (CAR) T-cell immunotherapies using its proprietary TALEN gene-editing technology and PulseAgile electroporation system; the company pioneers off-the-shelf UCART product candidates, including UCART19, UCART22, UCART20x22 and UCART123, targeting hematological malignancies such as B-cell acute lymphoblastic leukemia and acute myeloid leukemia, as well as non-Hodgkin lymphoma and other solid tumors; manufacturing operations support clinical and commercial-scale production of these therapies through facilities producing plasmids, mRNA, viral vectors and GMP-grade UCART cells. Founded in 1999 and headquartered in Paris, France, with additional sites in New York and Raleigh, North Carolina, Cellectis operates primarily in the oncology immunotherapy segment, serving cancer patients through clinical-stage programs and partnerships. The company maintains a robust intellectual property portfolio exceeding 100 patent families and global collaborations with Allogene Therapeutics, Servier, Iovance Biotherapeutics, AstraZeneca and others. In recent developments, Cellectis strengthened its financial position with $264 million in cash as of December 31, 2024, bolstered by a $140 million equity investment from AstraZeneca and full drawdown of a $45.5 million European Investment Bank facility; AstraZeneca's joint research collaboration, initiated in 2023, yielded $47 million in payments by year-end 2024, including milestones for up to 10 novel products in oncology, immunology and rare diseases across three initial programs; both manufacturing sites achieved full operational status in 2022, enabling in-house production advancements.