- Business
- Heidelberg Pharma AG, a clinical-stage biopharmaceutical company, develops innovative antibody-drug conjugates (ADCs) for targeted oncology therapies, focusing on its proprietary Antibody Targeted Amanitin Conjugate (ATAC) technology platform that utilizes Amanitin from the green death cap mushroom to overcome tumor resistance and eliminate dormant cancer cells in hematologic and solid tumors. The company advances a pipeline of ATAC candidates, including lead product HDP-101, a BCMA-targeted ATAC in Phase I/IIa clinical trials for relapsed or refractory multiple myeloma with dosing advanced to Cohort 9 at 175 µg/kg showing favorable safety, no dose-limiting toxicities, and early efficacy signals such as a very good partial response in one patient; HDP-102 for non-Hodgkin lymphoma; HDP-103 for metastatic castration-resistant prostate cancer; HDP-104 for gastrointestinal tumors; and HDP-201, an exatecan-based ADC for colorectal cancer; while also offering an ADC toolbox with diverse payloads and out-licensing legacy assets like girentuximab (Zircaix/TLX250-CDx) for renal cancer imaging and upamostat. Operations span Germany, the United States, and international markets through partnerships including Takeda and Telix Pharmaceuticals. Founded in 1997 as Wilex Biotechnology GmbH in Munich, the company restructured in 2011 with the acquisition of Heidelberg Pharma Research GmbH, relocated its headquarters to Ladenburg near Heidelberg, Germany, and changed its name to Heidelberg Pharma AG, listing on the Frankfurt Stock Exchange's Prime Standard (HPHA.DE). Recent developments include amending a royalty financing agreement with HealthCare Royalty in March 2025 for a USD 20 million upfront payment on TLX250-CDx royalties, extending cash runway into 2027 amid delayed FDA approval; reporting nine-month 2025 financials with reduced operating costs and focus on HDP-101; and advancing clinical progress in HDP-101 trials as of September 2025.