- Business
- Telix Pharmaceuticals Limited (ASX: TLX), a commercial-stage biopharmaceutical company founded in 2015 and headquartered in Melbourne, Australia, develops and commercializes diagnostic and therapeutic radiopharmaceuticals, or theranostics, focused on precision oncology for urologic (prostate, kidney, bladder), neuro-oncologic (glioma), musculoskeletal (sarcoma), and hematologic cancers. The company operates through Therapeutics, Precision Medicine, Medtech, and Manufacturing Solutions segments, offering products including Illuccix (kit for the preparation of 68Ga-PSMA-11 injection) for PSMA-PET/CT imaging in prostate cancer staging, recurrence detection, and therapy selection; Gozellix (TLX007-CDx), Pixclara (TLX101-CDx), and Zircaix (TLX250-CDx) diagnostic imaging agents for prostate, glioblastoma, and kidney cancers pending U.S. FDA approval in 2025; SENSEI miniature gamma probe for surgical guidance; dosimetry software; AI diagnostic platforms; and an extensive pipeline of late-stage therapeutics such as TLX591 (177Lu-rosopatamab tetraxetan) for castration-resistant prostate cancer in Phase III trials with interim data expected in H1 2025, TLX250 (177Lu-girentuximab) for clear cell renal cell carcinoma, TLX101 (131I-IPA) for glioblastoma, and 90Y-besilesomab for bone marrow conditioning, alongside early-stage alpha-emitters targeting PSMA, CAIX, FAP, LAT, and PDGFR-alpha, plus 153Sm-DOTMP for bone metastases palliation. Telix maintains commercial operations in the United States, Europe (Belgium, Switzerland), Japan, Australia, Canada, and the United Kingdom, with global manufacturing facilities including a major radiopharmaceutical production site opened in Belgium in 2023. Recent developments include the November 2024 announcement to expand its theranostic pipeline with FAP-targeting candidates initially for bladder cancer to complement its urology franchise; the acquisition of IsoTherapeutics in 2024 to bolster U.S. R&D and manufacturing infrastructure; planned pivotal trials in 2025 for Zircaix in renal carcinoma and Pixclara in glioblastoma; and a record presence at EANM 2025 showcasing CAIX and FAP theranostics.