PRISM BioLab Co., Ltd. (206A.T) develops small molecule inhibitors targeting protein-protein interactions using its proprietary PepMetics technology platform, which generates orally available compounds mimicking alpha-helix and beta-turn peptides to address undruggable targets in oncology, autoimmune diseases, fibrosis, and other indications; the PepMetics library comprises over 20,000 compounds for screening difficult therapeutic areas. Core pipeline assets include E7386, a CBP/beta-catenin inhibitor co-developed with Eisai Co., Ltd. in Phase II trials for cancer, and PRI-724, also targeting CBP/beta-catenin, advancing in Phase II for cirrhosis under license to Ohara Pharmaceutical Co., Ltd., alongside seed compounds for novel bicyclic PepMetics. Founded in 2006 and headquartered in Fujisawa, Japan, with a Tokyo office, the company operates primarily in Japan and pursues global collaborations. Recent developments encompass achievement of an initial milestone and receipt of upfront payment from Ono Pharmaceutical Co., Ltd. in a November 2025 drug discovery alliance for oncology targets; a new April 2025 partnership with Elix, Inc. to integrate AI-driven design into PepMetics research; patent grants in 2025 for novel bicyclic PepMetics compounds and library technologies; initiation of patient enrollment in a Phase I drug-drug interaction study for PRI-724; terminations of prior collaborations with Servier and Eli Lilly in 2025; a 1.5 billion yen Series C funding round in January 2024; and recruitment of key scientific talent in 2025 to bolster medicinal chemistry and translational pharmacology capabilities.