Actinogen Medical Limited is an Australian biotechnology firm dedicated to developing treatments for a range of neurological and neuropsychiatric conditions linked to imbalanced brain cortisol levels. The company is advancing Xanamem (emestedastat), an oral small molecule that selectively inhibits the 11β-HSD1 enzyme to modulate cortisol within the brain. Xanamem is currently undergoing a pivotal Phase 2b/3 clinical trial for Alzheimer's disease in Australia and the United States, targeting mild to moderate forms of the condition. Further, Xanamem has shown positive Phase 2a results for cognitive impairment in Major Depressive Disorder and is also being explored for its potential in Fragile X Syndrome. Established in 1999, the company adopted its current name in November 2015 and operates from Sydney, Australia.