Avacta Group Plc is a United Kingdom-based clinical-stage life sciences company that develops peptide drug conjugates using its proprietary pre|CISION platform to deliver potent cancer therapeutics selectively to tumors via fibroblast activation protein activation; the platform enables tumor-specific release of masked payloads including doxorubicin, exatecan and Affimer drug conjugates, reducing systemic toxicity in solid tumors such as breast cancer, head and neck cancers, gastric cancer, small cell lung cancer and soft tissue sarcomas. The company offers AVA6000, a first-generation pre|CISION peptide drug conjugate of doxorubicin in Phase 1b expansion cohorts for triple negative breast cancer, salivary gland cancer and soft tissue sarcoma; AVA6103, a second-generation conjugate of exatecan advancing to IND-enabling studies for gastric, breast, pancreatic and lung cancers with planned Phase 1 initiation in early 2026; AVA7100, a preclinical third-generation Affimer drug conjugate targeting FAP-low tumors; and additional preclinical dual-payload programs addressing resistance mechanisms. Founded in 2003 and headquartered at Scale Space, White City Imperial College Campus, 58 Wood Lane, London W12 7RZ, Avacta operates principally from the United Kingdom with revenue derived geographically from South Korea and internationally, focusing on the oncology therapeutics segment while pursuing divestment of its diagnostics subsidiary Coris Bioconcept to become a pure-play biotechnology firm. Recent developments include completion of AVA6000 Phase 1a dose escalation with favorable pharmacokinetics and efficacy signals including durable responses, entry into a strategic AI collaboration with Tempus AI for trial optimization and market expansion, ongoing commercial partnership discussions for pre|CISION assets, executive team strengthening with appointments such as David Bryant as director and Yulii Shvets as chief business officer, addition of Zeus Capital as joint broker alongside Peel Hunt and Panmure Liberum, and cash position bolstered to £17.3 million as of April 2025 following Launch Diagnostics divestment to extend runway into Q1 2026.