Shield Therapeutics plc (LSE:STX) is a UK-based commercial-stage specialty pharmaceutical company focused on developing and commercializing treatments for iron deficiency with or without anemia. The company offers ACCRUFeR®/Feraccru® (ferric maltol), a novel, stable, non-salt-based oral iron therapy indicated for adults across multiple therapeutic categories including inflammatory bowel disease, renal disease, and general iron deficiency; it is approved in the United States, European Union, United Kingdom, Canada, Australia, and Switzerland. Operations span North America, Europe, and Asia-Pacific through partnerships, with headquarters in Gateshead Quays, England; founded in 2008, subsidiaries include Shield Therapeutics Inc (US), Shield TX (Switzerland) AG, Shield TX (UK) Limited, and Phosphate Therapeutics Limited.
Recent developments include an 80% revenue increase to $21.4 million in the first half of 2025 driven by ACCRUFeR® growth, particularly as the top branded prescription oral iron in the US; a £1.5 million placing in September 2025 via 20 million new shares to support US expansion and working capital; and a $5.7 million cash receipt from AOP Health in exchange for China milestone rights. Strategic alliances encompass exclusive licenses with Viatris for US co-commercialization, Kye Pharmaceuticals for Canada (launched March 2025), VITAL-NET for Japan (April 2025, $665,000 upfront), Beijing Aosaikang Pharmaceutical for China/Hong Kong/Macau/Taiwan (Phase 3 completed for IBD patients, NDA filing pending), and Korea Pharma for South Korea. These partnerships and financings bolster global commercialization amid progress toward cash flow positivity by end-2025.