Theracryf Plc (LSE:TCF) is a clinical-stage biotechnology company focused on developing innovative therapeutics for oncology and behavioral brain disorders. The company advances a diversified pipeline including its lead clinical asset SFX-01, a patented sulforaphane-based medicine in Phase II trials for metastatic breast cancer, Phase I trials for glioblastoma in collaboration with Erasmus Medical Centre, and preclinical development for rhabdomyosarcoma and neurodevelopmental disorders; orexin-1 (Ox-1) antagonist programs targeting addiction, substance use disorders, anxiety, binge eating disorder, fatigue, and narcolepsy, funded to clinical trial readiness; and additional preclinical CNS assets addressing high unmet needs in neuropsychiatry. TheraCryf licenses global rights for SFX-01 in neurodevelopmental disorders and schizophrenia to Stalicla SA, and pursues a strategy of generating data for partnering or licensing with mid- to large-sized pharmaceutical companies.
Founded in 2014 and headquartered at Alderley Park, Nether Alderley, Cheshire, United Kingdom, the company operates primarily in the UK with international collaborations and targets global markets in oncology and CNS therapeutics.
In April 2024, TheraCryf, formerly Evgen Pharma Plc, acquired Chronos Therapeutics Ltd, tripling its research pipeline by integrating preclinical neuropsychiatry assets and prompting a rebranding to reflect its expanded mission; in February 2025, it raised gross proceeds of £4.25 million through a conditional equity placing to advance the Ox-1 program to clinical trial readiness and extend its cash runway to end-2026; post-period, it confirmed efficacy of an improved enteric-coated SFX-01 formulation in a Phase 1b study and presented preclinical data supporting its radiosensitizing potential in glioblastoma.