- Business
- Shenzhen Chipscreen Biosciences Co., Ltd. (688321.SS) engages in the research, development, production, and commercialization of original innovative small-molecule drugs targeting unmet clinical needs in oncology, metabolic diseases, autoimmune disorders, central nervous system disorders, and antivirals; its marketed products include Chidamide (Tucidinostat), an epigenetic modulator approved for peripheral T-cell lymphoma and, as of April 2024, combined with R-CHOP for previously untreated diffuse large B-cell lymphoma with positive MYC and BCL2 expression in China, and Chiglitazar Sodium (Carfloglitazar), a novel insulin sensitizer for type 2 diabetes; the company advances a robust pipeline featuring Chiauranib, a three-way targeted kinase inhibitor (Aurora B, CSF-1R, VEGFR, c-Kit) in phase III for advanced solid tumors, CS23546, a small-molecule PD-L1 dimer antagonist, CS231295, a brain-penetrant Aurora B selective inhibitor, CS32582, a highly selective TYK2 allosteric inhibitor for psoriasis and autoimmune conditions, CS12192, a JAK3 kinase inhibitor, and additional candidates like CS12088 and CS23074. Founded in March 2001 by senior Ph.D. experts returned from the United States and headquartered in Shenzhen, China, the company maintains a global footprint with facilities including a Chengdu regional headquarters and GMP production base, Beijing and Shanghai branches, and a U.S. subsidiary in New Jersey; it leverages an AI-assisted chemical genomics platform for drug discovery and early evaluation. Recent developments encompass expanded approvals for Chidamide in additional lymphoma indications, ongoing phase III trials for Chiauranib, phase II advancement of CS32582 for psoriasis, and a strengthened pipeline layout across five therapeutic areas to address neurodegenerative and other unmet needs, supported by over 700 global patents; the company listed as the first biopharmaceutical firm on China's STAR Market and continues global commercialization of its two marketed drugs across multiple indications in China, Japan, and Taiwan.