- Business
- argenx SE argenx SE is a commercial-stage global immunology company that develops differentiated antibody-based therapies for severe autoimmune diseases; it offers VYVGART (efgartigimod), a first-in-class FcRn blocker approved in more than 30 countries including the US, EU, UK, Japan, Israel, China and Australia for generalized myasthenia gravis (gMG) in both intravenous and subcutaneous formulations (VYVGART SC), for chronic inflammatory demyelinating polyneuropathy (CIDP) in the US, China and Japan (as VYVDURA), and for immune thrombocytopenia (ITP) in Japan (as VYVDURA); it advances empasiprubart, a C2 complement inhibitor in Phase 3 for multiple autoimmune indications including multifocal motor neuropathy; and it progresses earlier-stage candidates such as ARGX-119 (MuSK agonist) in proof-of-concept for congenital myasthenic syndrome, amyotrophic lateral sclerosis and spinal muscular atrophy, alongside preclinical assets ARGX-213 (FcRn), ARGX-121 (IgA), ARGX-220 and ARGX-109 (IL-6). The company leverages its Immunology Innovation Program (IIP) and proprietary technologies including SIMPLE ANTIBODY platform, NHANCE, ABDEG, POTELLIGENT and DHS mutations to engineer antibodies; it operates through subsidiaries in the US (Boston), Belgium (Zwijnaarde), Japan (Tokyo), France, UK, Netherlands, Switzerland, Germany, Canada, Italy, Spain, Portugal, Australia and Austria; founded in 2008 and headquartered in Amsterdam, Netherlands, argenx SE conducts R&D primarily in Belgium and commercializes products globally targeting underserved patients in immunology. Recent developments include expansion of its ENHANZE license agreement with Halozyme in September 2024 by nominating four additional targets for a total of six including FcRn and C2 to enable subcutaneous formulations; a new manufacturing partnership expansion with FUJIFILM featuring a site in North Carolina; topline results from the registrational EMPASSION Phase 3 study in multifocal motor neuropathy for empasiprubart; plans for five registrational readouts in 2026 and submission of a supplemental BLA for seronegative gMG by end-2025; and combined 2025 R&D and SG&A guidance of approximately $2.5 billion.