- Business
- BioLineRx Ltd. (NASDAQ/TASE: BLRX) develops and commercializes innovative therapeutics for oncology and rare diseases; the company focuses on advancing novel drug candidates through clinical development, leveraging expertise in stem cell mobilization, immuno-oncology, and targeted cancer therapies. Founded in 2003 and headquartered at 2 HaMa’ayan Street, Modi’in Technology Park, Hevel Modi’in, Israel, BioLineRx operates primarily in the United States and Israel, with strategic partnerships extending development and commercialization rights into Asia and other global territories. The company's lead product, APHEXDA (motixafortide), a high-affinity CXCR4 peptide inhibitor, is FDA-approved for stem cell mobilization in combination with filgrastim (G-CSF) for autologous transplantation in multiple myeloma patients; motixafortide is also in Phase 2b trials for first-line metastatic pancreatic ductal adenocarcinoma (PDAC) in combination with cemiplimab and chemotherapy (CheMo-4-METPANC study sponsored by Columbia University), Phase 1 trials for sickle cell disease stem cell mobilization (collaborations with Washington University and St. Jude Children’s Research Hospital), and subject to bridging studies for multiple myeloma in China. BioLineRx's pipeline emphasizes motixafortide's broad applicability across hematopoietic stem cell mobilization, solid tumors, and rare hematologic disorders, targeting unmet needs in cancer stem cell therapy and immune cell recruitment. In November 2024, BioLineRx entered an exclusive licensing agreement with Ayrmid Ltd. (parent of Gamida Cell) granting Ayrmid global rights (excluding Asia and solid tumors) to develop and commercialize APHEXDA, providing $10 million upfront, up to $87 million in milestones, 18-23% royalties, and a $9 million equity investment from Highbridge Capital Management, alongside significant cash burn reduction to extend runway into 2026; in October 2023, BioLineRx partnered with Guangzhou Gloria Biosciences for Asian rights to motixafortide across indications, including $15 million upfront, up to $250 million in milestones, and a $14.6 million equity investment, with GloriaBio advancing PDAC and multiple myeloma bridging studies in China and Japan. These non-dilutive deals support BioLineRx's transition to a lean development model, funding pipeline progression while generating initial APHEXDA revenues of $7.9 million in Q3 2024.