- Business
- Galapagos NV (GLPG.AS) is a clinical-stage biotechnology company focused on the discovery, development, and commercialization of novel medicines for inflammatory, fibrotic, and other unmet medical needs. The company offers a pipeline of product candidates including filgotinib, an oral JAK1 inhibitor for rheumatoid arthritis, ulcerative colitis, and Crohn's disease; Jyseleca (filgotinib), approved in Europe and Japan for rheumatoid arthritis and ulcerative colitis; and ziritaxestat (GLPG3970), a novel autotaxin inhibitor in Phase 2 for idiopathic pulmonary fibrosis; as well as other investigational therapies such as GLPG1205 (a sphingosine-1-phosphate 1 receptor modulator), GLPG1690 (an autotaxin inhibitor), and earlier-stage assets targeting fibrosis and inflammation. Galapagos operates primarily in the biopharmaceutical sector, targeting patients with autoimmune diseases, inflammatory conditions, and fibrosis through small molecule therapeutics; its customer base includes healthcare providers, regulatory authorities, and strategic partners in the pharmaceutical industry. Founded in 1998 and headquartered in Mechelen, Belgium, the company conducts research and development across Europe and the United States, with manufacturing and clinical trial operations supported by contract organizations globally. In recent developments, Galapagos restructured its collaboration with Gilead Sciences in 2023, regaining full rights to filgotinib outside Europe and Asia while receiving a €330 million upfront payment and potential milestones; the company also advanced its fibrosis franchise by initiating the Phase 2 RESPIRO-IC trial for ziritaxestat in interstitial lung disease associated with systemic sclerosis in 2024 and reported positive interim data from the Phase 2 PINTA trial in systemic sclerosis; additionally, in 2025, Galapagos expanded its pipeline through a strategic alliance with a undisclosed partner for novel inflammatory targets and completed a €150 million financing round to support late-stage clinical programs.