- Business
- Gujarat Themis Biosyn Limited manufactures active pharmaceutical ingredient intermediates through a specialized fermentation process; its core products include Rifamycin S, used primarily in the production of Rifampicin for treating tuberculosis, Mycobacterium avium complex, leprosy, and Legionnaires’ disease, and Rifamycin O, employed in manufacturing Rifaximin for traveler’s diarrhea, irritable bowel syndrome, and hepatic encephalopathy; the company holds over 50% domestic market share for Rifamycin S supplied to major clients like Lupin Pharmaceuticals and maintains long-term take-or-pay contracts with Lupin Limited (five-year term contributing 61% of sales) and Optrix Laboratories Private Limited (37% of sales, renewed annually). Incorporated in 1981 as a joint venture between Gujarat Industrial Investment Corporation Ltd. and Chemosyn (P) Ltd., with production commencing in 1985, the company was taken over in 1991 by Yuhan Corporation of South Korea and Pharmaceutical Business Group (India) Ltd., a consortium including Themis Medicare Ltd., Kopran Ltd., Anant & Co., Cadila Health Care Ltd., and Lyka Labs Ltd.; it operates from its CGMP-approved manufacturing facility in Vapi, Gujarat, with an installed capacity of 216 MT per annum for intermediates, serving domestic and international pharmaceutical markets focused on anti-tuberculosis and antibiotic segments. Actively managed by Themis Medicare Ltd. (a joint venture of Gedeon Richter Ltd., Hungary) since 2007, the company pursues ambitious expansion with a ₹155.62 crore capex program to double fermentation capacity from 216 MT to 432 MT by end-FY26 (₹52.43 crore incurred by March 2025, funded by ₹80.62 crore internal accruals and ₹75 crore term loan); it commenced operations of a new API unit for Rifapentine and Rifamycin in May 2025 per schedule, advancing forward integration from intermediates; equity shares listed on NSE in February 2025; Themis Medicare cancelled its proposed acquisition of remaining 76.8% stake in June 2025 to leverage GTBL’s independent growth strategy.