- Business
- Pfizer Inc. (NYSE: PFE; BCBA: PFE) develops, manufactures and markets biopharmaceutical products worldwide, including innovative medicines and vaccines targeting immunology, oncology, cardiology, endocrinology, neurology, rare diseases, inflammation, internal medicine and infectious diseases; principal products comprise Eliquis (apixaban, anticoagulant), Prevnar family (pneumococcal conjugate vaccines), Paxlovid (COVID-19 oral antiviral), Vyndaqel (tafamidis, for transthyretin amyloid cardiomyopathy), Comirnaty (COVID-19 vaccine with BioNTech), Ibrance (palbociclib, breast cancer therapy), alongside vaccines for respiratory syncytial virus (Abrysvo), meningococcal disease (Penbraya), influenza and others, cardiovascular therapies, oncology treatments including antibody-drug conjugates from Seagen, internal medicine offerings for obesity, type 2 diabetes and metabolic disorders, and inflammation/immunology drugs for rheumatoid arthritis, lupus and atopic dermatitis. The company, founded in 1849 by Charles Pfizer and Charles F. Erhart and headquartered at The Spiral in Hudson Yards, Manhattan, New York City, operates globally with major revenues from the United States (61% in 2024), China and other international markets, ranking fifth among largest biomedical companies by revenue and maintaining research facilities in Groton, Connecticut, the United Kingdom and India. Pfizer focuses on precision medicine, immunotherapy, gene therapy, mRNA technologies and AI-driven drug discovery, with a pipeline exceeding 100 candidates across Phase 1 to Registration stages as of November 2025, emphasizing oncology breakthroughs, obesity treatments like danuglipron (oral GLP-1 agonist), and next-generation vaccines. Recent developments include the November 2025 completion of its $7.0 billion acquisition of Metsera Inc., adding clinical-stage obesity and cardiometabolic assets such as MET-097i (injectable GLP-1 receptor agonist entering Phase 3), MET-233i (amylin analog), and oral GLP-1 candidates to bolster the internal medicine portfolio; a July 2024 Innovation Supply Chain partnership with Flagship Pioneering committing $50 million each to co-develop up to 10 drug candidates in obesity and cardiovascular areas with potential milestones up to $700 million per program; expanded AI collaborations with Saama for clinical trials and Ignition AI Accelerator for drug discovery and manufacturing optimization; and divestiture of its remaining stake in Haleon (consumer health joint venture with GlaxoSmithKline) in March 2025 for $3.24 billion to sharpen focus on innovative biopharma, alongside the 2023 $43 billion acquisition of Seagen enhancing oncology capabilities.