- Business
- Reviva Pharmaceuticals Holdings, Inc. (NASDAQ:RVPH) is a late-stage clinical biopharmaceutical company that discovers, develops and seeks to commercialize next-generation therapeutics addressing unmet medical needs in central nervous system, respiratory, inflammatory and cardiometabolic diseases. The company, founded in 2018 and headquartered in Cupertino, California, employs a chemical genomics-driven technology platform and proprietary chemistry to advance its pipeline, which centers on two new chemical entities discovered in-house: brilaroxazine (RP5063), a serotonin/dopamine modulator in phase 3 for schizophrenia, bipolar disorder, major depressive disorder and attention-deficit/hyperactivity disorder, with additional development for pulmonary arterial hypertension, idiopathic pulmonary fibrosis and topical psoriasis, as well as potential expansion into Parkinson's psychosis and Alzheimer's agitation; and RP1208, a triple reuptake inhibitor in preclinical stages targeting depression and obesity. Reviva operates primarily in the United States with global patent protections in key markets including Europe, China and Japan, focusing on patients with chronic neuropsychiatric and respiratory conditions. Recent developments include a $9 million public offering priced in September 2025 comprising 27 million shares and Series E/F warrants to fund brilaroxazine advancement; a planned Q4 2025 pre-NDA meeting with the FDA for schizophrenia ahead of a potential Q2 2026 NDA submission; grants of European and other international patents for brilaroxazine in pulmonary fibrosis; presentation of anti-inflammatory data from the RECOVER 12-month open-label extension trial at Neuroscience 2025; and prior 2024/2025 capital raises of $10 million in June 2025 and $18 million in December 2024 amid preparation for the RECOVER-2 phase 3 schizophrenia trial.