Scandion Oncology A/S is a clinical-stage biotechnology company specializing in developing novel therapeutics to overcome cancer drug resistance. The company's core product is SCO-101, an oral add-on therapy designed to enhance the efficacy of standard chemotherapy by inhibiting drug efflux pumps, specifically targeting ABCG2 and UGT1A1 mechanisms associated with chemotherapy resistance. SCO-101 is under clinical investigation in Phase IIa for metastatic colorectal cancer (CORIST trial) and Phase Ib for unresectable or metastatic pancreatic cancer (PANTAX trial), with preclinical evaluations ongoing for gastric cancer and solid tumors. Scandion also develops SCO-201, a preclinical candidate aimed at treating solid tumors and HIV. Founded in 2017 and headquartered in Copenhagen, Denmark, the company operates primarily within oncology pharmaceuticals and biopharmaceuticals development.
In recent major developments, Scandion Oncology has entered voluntary solvent liquidation as of 2025 and has applied for delisting from Nasdaq First North Growth Market Sweden. The company intensifies its partnering and business development efforts, collaborating with investment banking firms to seek strategic alliances and partnerships in the first half of 2025 aimed at advancing further clinical development and commercialization of SCO-101. These efforts follow positive Phase IIa clinical trial results demonstrating SCO-101's efficacy in improving chemotherapy outcomes in drug-resistant metastatic colorectal cancer. The company also completed a rights issue earlier in 2024 to secure funding for its ongoing operations and strategic initiatives. Scandion's focus remains on developing first-in-class medicines that specifically target molecular mechanisms of drug resistance in cancer treatment with the aim of improving patient outcomes worldwide.