Solvonis Therapeutics plc
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- Solvonis Therapeutics plc (LSE: SVNS) is a clinical-stage biopharmaceutical company that develops novel small-molecule therapeutics and repurposed compounds for high-burden central nervous system disorders, with a primary focus on addiction, psychiatry and neurology. The company advances a differentiated pipeline targeting neuropsychiatric conditions including Alcohol Use Disorder (AUD), affecting over 40 million people across the US, UK and EU4 markets; Post-Traumatic Stress Disorder (PTSD), impacting more than 13 million adults in the US and 20 million across those regions; and emerging areas such as depression, stimulant use disorders involving methamphetamine and cocaine, and comorbid conditions with significant unmet needs. Core assets comprise SVN-001, a novel combination therapy of intravenous ketamine and proprietary cognitive behavioural therapy in Phase 3 for severe AUD across eight UK NHS Trusts, co-funded by the UK Medical Research Council and National Institute for Health and Care Research with completion expected in late 2026 or early 2027; SVN-002 preparing for Phase 2b trials in the US for moderate-to-severe AUD; SVN-SDN-14, a preclinical serotonin-dopamine modulator for PTSD designed to enhance pro-social behaviour and long-term outcomes with positive preclinical results reported in August 2025; and an AI-enabled discovery platform integrating proprietary CNS compound libraries, predictive modelling and translational tools to identify modulators for depression and stimulant addictions. Solvonis Therapeutics plc maintains headquarters in London, UK, where it was originally incorporated, and conducts operations primarily in the UK and US with preclinical and clinical activities extending to EU markets. In recent developments, the company completed the acquisition of Awakn Life Sciences Corp in August 2025, significantly expanding its R&D pipeline by integrating AWKN-001 as SVN-001 and positioning Solvonis as a leader in addiction and mental health therapeutics; raised gross proceeds of 1.25 million pounds in October 2025 through subscription with institutional and strategic investors to advance clinical programmes, expand CNS drug discovery across its three-pillar strategy and strengthen R&D capabilities; secured a 1.0 million pounds subscription from major shareholders in July 2025 to accelerate AI-supported discovery for major depressive disorder and stimulant use disorders; announced in December 2025 that AI-discovered SVN-015 for methamphetamine and cocaine use disorders was accepted into the US National Institute on Drug Abuse Addiction Treatment Discovery Program for funded preclinical evaluation, potentially leading to NIH clinical funding; and appointed global biopharma leader Paul Carter as Non-Executive Director in October 2025 to support strategic growth.
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