- Business
- PeptiDream Inc. (4587.T), a public biopharmaceutical company founded in 2006 and headquartered in Kawasaki, Japan, engages in the discovery, development and commercialization of constrained peptides, small molecules and peptide-drug conjugate therapeutics; macrocyclic peptide-based therapeutics and diagnostics; peptide-drug conjugates including radioligand therapies and multi-functional peptide conjugates; and radiopharmaceutical and radio-diagnostic products. The company leverages its proprietary Peptide Discovery Platform System (PDPS) to generate non-standard peptide libraries for identifying potent, selective macrocyclic peptide candidates targeting oncology, immunology, metabolic disorders, neuromuscular conditions, infectious diseases and allergic indications, with a development pipeline featuring PD-L1 (Ph1), PD-L1 BMS-986229 (Ph1), CD38 BHV-1100 + NK cells for multiple myeloma (Ph1), GhR AZP-3813 for acromegaly/NET (Ph1), preclinical programs including Glypican-3 for liver cancer, Myostatin for DMD/muscle disorders, TfR for neuromuscular disorders, c-Kit for allergic conditions, c-Met and HA-protein for influenza. PeptiDream operates primarily through its Drug Discovery and Development segment via strategic research collaborations, technology licensing of PDPS and pipeline expansion with global pharmaceutical partners including Novartis, MSD (Merck), Genentech and Bristol Myers Squibb, serving therapeutic areas across oncology, central nervous system disorders and metabolic diseases with worldwide geographic reach. Recent developments include a 2024 expansion of its long-standing peptide discovery collaboration with Novartis granting exclusive global rights for radioligand therapy programs using PDPS-optimized macrocyclic peptides conjugated with radionuclides, featuring $180 million upfront payment and up to $2.7 billion in milestones plus royalties; ongoing multi-target partnerships such as with MSD for peptide drug conjugates; and pipeline advancements including multiple Phase 1 clinical programs.