- CEO
- Hermann Lbbert
- Full Time Employees
- 149
- Sector
- Healthcare
- Industry
- Drug Manufacturers - Specialty & Generic
- Address
- Hemmelrather Weg 201 Leverkusen Germany 51377
- IPO Date
- Feb 14, 2018
- Business
- Biofrontera AG is a Germany-based biopharmaceutical company specializing in the development, manufacturing, and commercialization of prescription dermatological drugs and medical cosmetics primarily for the treatment of skin diseases. The company’s core products include Ameluz®, a photoactivated drug indicated for the treatment of actinic keratosis and basal cell carcinoma; BF-RhodoLED®, a proprietary lamp series that emits red light for photodynamic therapy (PDT); and cosmeceutical products under the Belixos® brand. Biofrontera also provides complementary dermatological products such as Advantan® and Skinoren® through strategic co-promotion partnerships, notably with LEO Pharma in Germany. The company operates sales organizations in Germany, Spain, and the United Kingdom, alongside licensing agreements expanding its geographic reach. Founded in 1997 and headquartered in Leverkusen, Germany, Biofrontera targets dermatologists, clinics, and pharmacies as its principal customers within Europe and select international markets.
Recent major changes include the completion of a strategic sale and restructuring agreement with its U.S. subsidiary Biofrontera Inc., whereby Biofrontera AG transferred all U.S. assets, liabilities, and rights related to Ameluz® and BF-RhodoLED®, including New Drug Applications and manufacturing contracts, to Biofrontera Inc. This transition, finalized in late 2025, has enabled Biofrontera AG to focus on optimizing and expanding its European business operations while securing a 10% equity stake in Biofrontera Inc., thereby aligning interests. Additionally, Biofrontera AG has signed new distribution agreements, including a partnership with Propharma d.o.o. for Ameluz® distribution in Croatia and Galenica AB for promoting Ovixan® in the UK. The company successfully launched an improved formulation of Ameluz® without propylene glycol to enhance safety and extend market exclusivity, and expanded its product portfolio through licensing and co-promotion collaborations such as with LEO Pharma to market well-established dermatological products in Germany. These strategic moves underscore Biofrontera AG’s repositioning towards strengthening its European market presence and streamlined operational structure.
The company operates primarily in the prescription dermatology segment, offering photodynamic therapy products, medical cosmetics, and licensed dermatology treatments. Its flagship product Ameluz® remains a market leader in photodynamic therapy in Europe, with ongoing efforts to expand its approved indications and applications. Biofrontera maintains a strong R&D focus on product innovation and label expansions, supported by its proprietary nanoemulsion technology. Its operational focus spans key European countries including Germany, Spain, the UK, and Croatia, with recent efforts aimed at broader European market expansions through licensing and distribution partnerships.
Biofrontera AG’s strategic evolution reflects a deliberate shift towards consolidating its core European dermatology markets and enhancing profitability through targeted partnerships, portfolio diversification, and operational efficiencies. The company continues to leverage its innovative dermatological product lines and strategic alliances to capture market share and drive growth within the competitive biopharmaceutical landscape.