Operator
Ladies and gentlemen, good day, and welcome to the Sai Life Sciences Limited Q1 FY27 earnings conference call. As a reminder, all participant lines will be in the listen-only mode, and there will be an opportunity for you to ask questions after the presentation concludes.
Should you need assistance during the conference call, please signal an operator by pressing star and then zero on your touchtone phone. Please note that this conference is being recorded.
I now hand the conference over to Mr. Diwakar Pingle from EY Investor Relations.
Thank you, and over to you, sir.
Diwakar Pingle
Thank you so much, Sagar. Good evening to all the participants on this call.
Warmly welcome you to the Q1 FY27 earnings call of Sai Life Sciences Limited. Before we proceed on the call, let me remind you that the discussion may contain forward-looking statements that involve known, unknown risks, uncertainties, and other factors.
It must be viewed in conjunction with our business risks that could cause future result performance or achievement to differ significantly from what is expressed or implied by such forward-looking statements. Please note that we've mailed the results, and the same are available on the website, too.
In case you've not received the same, you can write to my team at EY, and we'll be happy to send the same over to you. To take us through the results and answer your questions today, we have the top management of Sai Life Sciences Limited represented by Mr.
Krishna Kanumuri, Managing Director and Chief Executive Officer, and Mr. Chittor, Whole-time Director and Chief Financial Officer.
We will start the call with a brief overview of the quarter gone past and then conduct the Q&A session. With that said, I'll now hand over the call to Krishna Kanumuri.
Over to you, Krishna.
Krishna Kanumuri
Thank you, Diwakar. Good evening, everyone, and thank you for joining us for our Q1 FY27 earnings call.
We're pleased with the progress we have made in the first quarter and, importantly, with the momentum we are seeing across our business. Revenues from the quarter grew by 12% year-over-year, supported by growth across two businesses, particularly the CRO, which grew by 26% year-over-year.
The Q1 performance has been in line with our expectations, and we remain confident of our growth trajectory and prospects. As we had discussed in the previous earnings call, we expect a stronger H2 with planned capacity expansion going live in the second half of the year.
As we look ahead, we believe Sai is at an important point in its evolution from being a strong small-molecule CRDMO to becoming a technology-led, multimodality partner with capabilities spanning discovery through commercial manufacturing. Let me begin with the broader environment.
From our customers' standpoint, geopolitical uncertainty and concerns around intellectual property have made India an increasingly important part of their diversification strategies. I would say this trend has not only continued, but strengthened.
In the biotech environment, we've seen several large acquisitions and about 18 IPOs in the US. As investors cash out, we expect capital to flow back into funding new biotech companies.
The clear message we're picking up is that these new companies will be built with even leaner in-house capabilities, which should continue to support healthy demand for our sector. Our pipeline is being built for the long haul.
Through dedicated FTE models, we are building deep, durable relationships with our customers' development teams. This is impacting our pipeline in three distinct ways: molecules from biotech companies that we have supported being acquired by our pharma collaborators, molecules from acquired companies transferred to us, and finally, molecules from our FTE relationships progressing to late-stage development.
Together, these three create a broad and sustainable funnel for the business. As we engage with our customers, it is clear that the complexity and range of technologies they are pursuing are broader than ever.
This aligns very well with our strategy of building strong R&D capabilities across diverse range of modalities. We believe the biggest long-term opportunity is to continue building a fully integrated delivery engine from discovery through commercial manufacturing.
We're seeing a clear traction with our clients beginning to engage across the full spectrum of our services. We are well-positioned for transitioning from an integrated small-molecule CRDMO to a full-fledged multimodality integrated CRDMO.
We've already made meaningful progress and will continue to accelerate this build-out. Peptides are an important modality for us.
We have one of the largest and fastest-growing peptide teams within discovery. While GLP-1s receive significant attention, there is substantial work underway in macrocyclic peptides, peptide-drug conjugates, and newer chemistry applications.
Our first dedicated peptide development lab is coming online shortly for a top-tier pharma company. We're also expanding the scope of our peptide center of excellence to support both discovery and development teams with ability to deliver pilot quantities for clinical trials.
In addition, we plan to break through a peptide manufacturing facility at our new greenfield site near Hyderabad, which is expected to be operational in 2028. We're close to opening our XDC center of excellence, which will support both discovery and development teams in the synthesis of payloads, linkers, and conjugation across antibodies, peptides, PROTACs, and oligonucleotides.
There's increased need to support our development programs with greater speed and flexibility. We're working on building new capacity specifically designed for early- to mid-stage deliveries, and it'll be an important part of our expansion at our new greenfield manufacturing site.
Formulations is another area we're entering. While we're still about 6 months away from being operationally ready, we're seeing significant interest from our pharma partners.
There's a clear demand for integrated offering that can deliver both first-in-human APIs and drug products with speed, helping customers accelerate development timelines. Scientific excellence remains the heart of this evolution.
For the past few years, we have deliberately invested in strengthening our scientific capabilities, infrastructure, and talent across the organization. Recent successes have reinforced the belief that we are on the right trajectory.
For example, we've integrated delivery capabilities in ADC, bioconjugation, characterization, and analysis, and recently published our work in a high-impact, peer-reviewed scientific journal. During the quarter, we also published a joint paper with AstraZeneca on experimental approach to determining reaction kinetics early in development.
Objective is to generate better process understanding earlier in the life cycle and ultimately support smoother scale-up and technology transfer. We believe these are important indicators of the scientific depth we are building at Sai, not only in terms of services we provide to customers, but also in our ability to develop and contribute new approaches to solving complex scientific and technical problems.
Technology remains central to the proposition we offer customers. We're making meaningful progress in advanced process technologies.
Recently, we successfully scaled up a late-stage GMP intermediate for a large pharmaceutical customer at our manufacturing facility using flow chemistry. We expanded continuous downstream operations including extraction, distillation, crystallization with the longer-term objective to developing more flow applications in our commercial manufacturing.
These capabilities are particularly relevant as we see increasing complexity of molecules entering our development and manufacturing pipeline. Talent development is an important part of this journey.
We have kick-started a campus strategy program led by a former board member. The objective is establishing Sai as an employer of choice for life science talent.
We're putting in place a more structured approach to how we attract, develop, and retain scientific and technical talent. We're establishing structured management development programs for first-time and experienced managers based on external technical and behavioral assessments, making them more targeted and outcome-oriented.
We've also increased the intensity of Sai Academy, our strategic capability building program designed to create common scientific, technical, and operational standards across the organization. We believe building this depth of talent and capability is essential as we take on more complex programs and move into new modalities.
In conclusion, there's a clear evolution of what large pharmaceutical companies are looking for from their outsourcing partners: expectations of strong, scientifically-led partners who can take greater ownership of discovery and development programs rather than simply execute individual pieces of work. We believe that the combination of our technology base, scientific talent, and culture is a key reason why large pharmaceutical companies are increasingly bringing significant work to Sai through strategic engagements.
These engagements will create a healthy and sustained pipeline over multiple years. With that, let me hand over to our CFO, Siva, to take you through the financial performance and progress we're making in the business.
Siva Chittor
Thanks, Krishna. Good evening, good morning, everyone.
Let me start with the financial performance for the quarter and provide commentary on the two businesses. For the quarter ended Q1 FY27, total revenues stood at ₹553 crores, representing a year-on-year increase of about 12% compared to ₹496 crores in the quarter last year.
The CDMO business contributed approximately 60% of our revenues and the CRO business the remaining 40%. On a y-o-y basis, CRO revenues increased by about 26%, while the CDMO revenues grew by around 5%.
Our balance sheet remains healthy, and we continue to maintain the financial flexibility required to invest behind opportunities we see across the business. We will continue to balance investments in future growth with disciplined capital allocation and returns.
In the discovery business, the discovery chemistry services continue to scale. During the quarter, we successfully converted a pilot collaboration with a large pharmaceutical company into a long-term, high-volume discovery chemistry partnership.
This is exactly the kind of progression we were looking for: starting with a focused engagement, demonstrating value, and expanding the relationship over time. We've also completed a large-scale DMPK data generation project for a biotech customer and have continued to build capacity to support our growing base of large pharmaceutical customers.
A few years ago, we made a deliberate decision to move beyond being a low-value chemistry services provider and invest significantly in biology and DMPK, while continuing to expand our discovery chemistry capability. Those investments in infrastructure, technology, and people are now translating into integrated service delivery for approximately 65% of our customers, today primarily biotech customers.
We are now seeing the same model gaining traction with large pharma. We are already in discussions with several large pharmaceutical companies and hope to transition at least two large pharmaceutical customers to an integrated model this year.
Moving now to the CMC business, the underlying health of the CMC business continues to be strong, with 33 active commercial molecules and 14 molecules in late phase. As Krishna mentioned in his opening remarks, dedicated FTE development contracts are expected to be a key differentiator for Sai Life Sciences in augmenting our pipeline of late-phase and commercial molecules.
Over the last 15 months, we have added six late-phase molecules to our pipeline. Five of these have come through large pharma clients with whom we have ongoing FTE engagements.
One such collaboration with a top-tier market pharma company, which began at a small scale, has now expanded into a sizeable dedicated FTE contract. With this customer, our engagement now extends end-to-end, truly from discovery to commercial, with active programs across the life cycle from early discovery to late-stage manufacturing.
We've also begun negotiations for another large pharma FTE engagement on the process development side, which we expect to close by the end of Q2, with work expected to commence from Q3. With respect to the phase 3 pipeline, one of our customers received an approval during FY26, two more have regulatory milestones during this financial year, and one is expected in Q2 of FY28.
An equally important indicator of the quality of our customer relationship is the level of repeat business we generate. We continue to add new customers, but returning customers accounted for over 90% of our revenue in fiscal '25 and '26.
We believe this is a strong reflection of customer satisfaction and the value we are creating for customers over the course of their programs. It also reflects our ability to deepen engagement with clients over time.
We're also increasingly seeing evidence of our ability to support customers through the full life cycle. In calendar 2025, Sai contributed to five FDA-approved molecules, meaning we were part of either discovery or development or commercial manufacturing for the product.
Over the past 5 years, we have supported 17 launches, demonstrating our ability to supply launch quantities and play a meaningful role in commercialization. I am also pleased to report that we secured the prestigious EcoVadis Platinum rating 2026, placing us among the top 1% of the companies assessed worldwide for sustainability performance.
Overall, we believe the quarter reflects continued progress across both the businesses and our longer-term strategic priorities. Notwithstanding the inherent lumpiness in the business, the long-term opportunity for the CRDMO sector remains robust, and our integrated model with strong pharma relationship and technology investments position us well for sustained growth.
We remain confident in our ability to sustain our longer-term revenue growth guidance of 15% to 20% and EBITDA range of 28% to 30%. With that, we'll be happy to take your questions.
Operator
Thank you very much. We will now begin with a question and answer session.
Anyone who wishes to ask a question may press star and then one on their touchtone phone. If you wish to remove yourself from the question queue, you may press star and two.
Participants are requested to use handsets while asking a question. Ladies and gentlemen, we will wait for a moment while the question queue assembles.
Again, to register for a question, please press star and then one. Your first question comes from the line of Binay Singh with Morgan Stanley.
Please go ahead.
Binay Singh
Hi, team. Thanks for the opportunity.
In the opening comments, we talked about strengthening relationship with big pharma, we talked about integrated CRDMO, long-term discovery contracts, more FTEs, and you also made a comment on intellectual property. Do you think these things are accelerated this calendar year, or it's more a continuation of what you were seeing last year also was similar, or there is some sort of a change in environment where we are highlighting these more in this calendar year?
Krishna Kanumuri
Binay, I think if you're looking at the progression of business, I think if you look at what is really happening, customers are trying to build sustained relationships over the next 5, 10 years. You will see a gradual increase in these relationships in terms of one service at a time and starting small and growing big.
I think we're very early part of this journey in terms of clients' relationships, we think that these relationships all have potential to expand significantly over the next 5, 10 years. I think they're all in the early stage of evolution, but we're seeing acceleration in terms of the scale and scope of the services we offer.
Siva Chittor
I think just to add, Binay, I think when we started, for example, on the FTE relationship that you pointed, right? We started this 15 months ago.
We said this is starting small. We know this is very different.
This was all China-built. Some of the largest CDMOs, and we said we are seeing this for the first time in India.
If you look at where we are today, we are saying in one customer we're already on an end-to-end basis. We are talking about molecules that are transitioned, it's not just early-phase development, it's late-phase development.
As Krishna mentioned, we're talking about molecules that are being acquired by pharma that is being pushed into our FTE development so that a robust development process can be developed and then scaled up. I talked about six molecules in phase 3 over the last 15 months come to this process.
There is a progression happening. I think the broader sentiments are there.
It's to remain the same, but as we kind of get into this and start working with the customers, acceleration with respect to Sai is what we're seeing. That's the sentiment that we are experiencing.
Krishna Kanumuri
Binay, to give you a little more context, right? If you look at, let's say, the WuXi model, the customers are doing integrated discovery services, then they're doing all the FTE development services, and commercial manufacturing.
What India has seen as a first phase is discovery chemistry services and then tech transfer at late stage commercial manufacturing. What we are seeing now is the middle part, which is the FTE collaboration where basically WuXi had built all the relationships starting to migrate here, and we're also starting early phases of that discovery programs growing into integrated programs.
It just shows that this is a very early part of opportunity. I think these have a long way to go in terms of scale.
Binay Singh
Thanks for that detailed answer, team. My second question is earlier in the call, I think in the last call, Krishna had commented that how in financial year '27, the second half will be stronger than the first half.
If you see in the past also, leaving aside financial year '26, that is generally the trend, 40-60 between first half, second half. This year you called it out is more because of more capacity coming this year that the skew of second half will be a little heavier than first half?
Is that the reason you had called it out?
Siva Chittor
That is true, plus also fiscal '26 for us was a little out of the ordinary in terms of how our numbers panned out. We were roughly 48-52, if I remember the number right, Binay.
Fiscal '26 for us was slightly, I would say, very different. It is always been historically 40-60 kind of a period, but fiscal '26 kind of was almost flat, and hence we just the last call just to kind of make sure that we kind of gave advance intimation on how we are seeing our next year.
Great,
Binay Singh
great. Thanks, team.
I'll come back in the queue.
Siva Chittor
Thank you.
Operator
Thank you. Participants, if you wish to register for a question, please press star and then one.
Your next question comes from Amey Chalke with JM Financial. Please go ahead.
Amey Chalke
Thank you for taking my question and congrats to the management on good numbers. I have first question on on CRO.
We have said in the opening remark also in PPT that we have added one large customer in the CRO side on in chemistry in this quarter. What has worked in our favor to convert this relationship and also how big is this relation- ship could be for us in terms of number of projects or revenue, if any quantification you can provide.
Thank you.
Krishna Kanumuri
Generally, we don't quantify what we're doing with each customer. It's just not one.
We converted a couple this quarter, I think there's multiple ways we're actually converting. It's just not one.
Some of them are converting more linearly, some of them are basically going more integrated. We have more than one customers expanded collaboration for this quarter.
Amey Chalke
Sure. Your voice is not that clear, but what I heard is our integrated platform it is what helped us to convert these customer.
Is that right or?
Krishna Kanumuri
No, I'm just saying we're seeing both growth in terms of scale in terms of certain lines of service, let's say discovery chemistry, but some customers are also expanding more gradually in terms of integrated services as well. This growth is not only to be one customer, there're multiple customers this way who have potential to scale up with us.
Amey Chalke
Got it. The second question I have on the four commercial contracts which will be added this year.
I think three of them have been added in the first quarter. Is it possible for us to give some clarity in terms of modalities where these four products would be and also whether we would be a primary supplier or the secondary supplier for these projects?
Have these projects been already commercialized or these are newly commercialized products? Thank you.
Siva Chittor
Three of the four that we will be working on this year, as we had mentioned during the last call, will be commercial supplies. Primary, secondary, as we discussed before, right, I think we probably are primary in two out of the three, but this is more anecdotal than what I can tell you at this point in time.
Or
Amey Chalke
at least if you can provide the revenue per product potential, would it be in line with some of our top commercial products, or it will be sizably below or over and above that, if you can give color on that?
Siva Chittor
I think what we had mentioned in the last call, Amey, was that we said this would be a decently-sized product. Looking at our size and revenue, we said this is a decently-sized product.
Three of them would be decently-sized products and one of them will be a lower-volume product, is what we had The fourth one, we said will be a lower-volume product. That's what we had mentioned last year.
Last quarter. We'll stay with the same comment.
Amey Chalke
By size, you mean value or volume for all three?
Siva Chittor
Value. Volume does not matter, right?
Value is what I'm talking about. I'm talking value as with respect to how our revenues are.
I think it's a decent-sized value. Sure,
Amey Chalke
sure. Thank you so much.
One more question I have on the formulation capabilities where we are entering. What kind of formulation capabilities would that be?
I think we have written drug product. Is it a biologic in the fill and finish facility which we expect to construct here, or is it something else?
What visibility we have in the pipeline for these projects?
Krishna Kanumuri
As of now, we're building the small-molecule primarily oral solids of different forms up to phase 1 and phase 2. We have significant interest from multiple of our large pharma partners already who are working with us on the chemistry side to be able to support demand for early clinical formulation.
We have significant interest for that piece.
Amey Chalke
Typically we have not seen CDMOs entering into oral solid formulation capabilities. What's the thought process here?
The reason being is the profitability in these segments are typically on a lower side. Is it something different for these projects?
Krishna Kanumuri
Right now we're only talking about clinical up to phase 2 supplies. We're not talking about commercial supplies at this point.
This was driven by our discussions with customers of where the need is. Their need is very specific to supplied China+1, where they're getting a lot of clinical materials early phase, and this fits in with the China+1 strategy of our partners at this point.
This only works well when you have existing relationship on the development side, not standalone.
Amey Chalke
Sure, sir. Thank you so much.
I will join back in the queue. Thank you.
Cool.
Operator
Thank you. A reminder to all the participants, if you wish to register for a question, please press star and then one.
Your next question comes from the line of Akshay from AK Investment. Please go ahead.
Hi, sir. Thanks for the opportunity.
Sir, my first question is about the therapeutic-wise split in the revenue. What is the therapy-wise currently split or exposure for different therapeutic mix in the revenue, and also in the pipeline as well, which are the therapeutics areas are we focusing on?
Siva Chittor
I think we've given the therapeutic distribution for the last financial year. I think that's part of the investor deck.
We do it on an annual basis. On a quarterly basis, it does not make any sense.
It's available in the deck that we've uploaded on the investor presentation. We've given you a detailed presentation on that one.
This is, if I remember, it's slide number 20 on the investor presentation.
Sir. For the pipeline in the product as well, that would be more or less similar in that line also?
Siva Chittor
I'm sorry? Can you repeat your question, please?
Yeah. Definitely.
Sir, also for the products in pipeline as well, that split will be more or less similar in that category as well?
Siva Chittor
It's difficult to say, right? It's about what our pharma customers are looking to innovate on.
Finally, we will be driven by what the innovator pipeline looks like. This is just a reflection of where we are today or how our revenues were in the last year.
At least from our books' perspective, that's really what we have reflected there.
Sir. My second question is, what is the capex guidance for FY27 and FY28?
Siva Chittor
What is that for '27 and '28, sir?
Capex, capital expenditure guidance for FY27 and '28.
Siva Chittor
We have given an FY27 capex guidance of 1,100 to 1,300 crores, that still stands. We haven't provided a guidance on fiscal '28.
We will come back to you with a guidance at an appropriate time.
Sir. Fair enough.
Thank you so much, and all the best.
Siva Chittor
Thank you.
Operator
Thank you. Your next question comes from the line of Sajal Kapoor with Antifragile Thinking.
Please go ahead. Hey,
Sajal Kapoor
yeah, thank you. Hi, Krishna and Siva.
Congratulations. What stands out over the last year is not just the growth, but the deepening big pharma relationships and Sai getting involved earlier in the development cycle, very well done.
Two questions. You mentioned that five of the six late-phase molecules added over the last 15 months came through large pharma FTE relationships.
Does getting involved through these dedicated development teams materially increase Sai's probability of retaining those molecules for commercial manufacturing versus programs where you enter later through an RFP or tech transfer? Thank you.
Krishna Kanumuri
The first intent of every pharma company is to leave the program with us for commercial. I think it's only in the cases where there might be maybe a mismatch in capacity we would devolve, but the primary intent, a stated intent, is leave it with Sai all the way through the life cycle of the product.
Sajal Kapoor
Sure. You also said around 65% of discovery customers now use integrated services, and you hope to transition at least two large pharma customers to that model this year.
As the large pharma moves from single-service engagements to integrated programs, do you see a meaningful change in revenue per customer and relationship duration? In other words, getting more wallet share per relationship?
Krishna Kanumuri
Truly.
Siva Chittor
Yes, Sajal. Yes, so that's the reason we also brought out the point on if we look at our growth, right, last year we grew 30%, but 90% more than 90% of our revenue came from our existing customers.
Whatever we've done over the last few years is kind of now that you are working with 19 of the top 25 pharma companies, there's a tailwind with respect to how India outsourcing is panning out. The objective is to go find out how much wallet share can you increase.
You want to be careful when you do the wallet share increase. One, we want to increase commercial, but we also want to increase the spectrum of services that we go.
We are able to then transition work across. We're able to kind of be present in every part of their services, and it also helps us de-risk our overall revenue concentration even within the same customer.
No,
Sajal Kapoor
can I ask one more, please?
Siva Chittor
Sure.
Sajal Kapoor
Thank you. You are entering a much heavier investment cycle with up to 1,300 crore of capex, which includes a greenfield for peptides.
Given the greater customer and pipeline visibility you now have, what internal return threshold do you use before committing this capital, and what would make you slow down or defer an investment? Thank you.
Siva Chittor
Typically we have certain internal hurdle rates, which will be generally higher than the ROCE, ROE from a company perspective targets that we put. That would be slightly higher than that, we kind of use that as a model.
Then we kind of stress-test this based on what we are seeing. We evaluate capital expenditure as we kind of put things in.
There are certain expenditures that you are putting in because you have to build a capability and you are expecting certain amount of revenue based on certain assumptions once you build that capability. In those cases, it may be slightly difficult to defer unless there are severe business circumstances.
If you're doing a capacity addition, we evaluate the capacity addition as we kind of run through our capex. There are times in history where, even in Sai, we've demonstrated that when we have seen capacity addition requirement slows down, we slow down the capex, and that's the only way to kind of control and be modular and be as just in time as possible as is needed for the business.
Sajal Kapoor
No, that's very helpful. Thank you so much.
Wish you all the very best.
Siva Chittor
Thank you.
Operator
Thank you. Participants, you may press star and then one to ask a question.
Your next question comes from the line of Siddharth Nigandi with CWC. Please go ahead.
Siddharth Nigandi
Hi. Thank you for the opportunity.
One of the things that you've mentioned in previous presentations is to share updates on AI initiatives that you've been taking. This time you've mentioned about a high-throughput experimentation platform.
Just wanted to understand if that was basically the AI initiative that you were talking about or if you could give us some color on that. In terms of the capacity expansion that is there, just a check on whether that is in line as what we'd guided earlier, or do we see that timeline moving in any way?
Those were my two questions.
Siva Chittor
On this capacity addition, I think in the deck we've mentioned we're largely on schedule. You could see 1, 2 months, but essentially So, we talked about a few things at the end of last quarter, or when we began this financial year, we talked about a discovery capacity that we were going to build that was going to come on stream in Q1.
That facility has come on stream in Q1. That facility is actually sold out at this point in time.
What we thought we will probably need a year to fill in or year and a half to fill in has already been filled in. On the capacity in Bidar, we had talked about building two production blocks of 225 kL each, totaling to 450 kL.
The first production block will come on stream. We had talked about plant getting completed and ready for operation in H2 or Q3.
The plant currently remains the same, and we're on track for that. I think broadly other capabilities we talked about we will bring a formulation capacity into operation this year.
Krishna just mentioned we're 6 months away, it still will be in the current fiscal year. Broadly, we are on track for this.
On the first question on AI, I think AI is slightly different. I think the HTE is more high-throughput experimentation that kind of allows you to kind of do multiple scenarios and kind of generate more data points on the same experiment.
The AI initiative that we talked about is slightly different. This more focuses on how you can eliminate wastages in terms of non-value add as today a chemist or an operator at the plant are doing.
It is necessary, but it's not the core value add that we can substitute with either some help from AI, some help from document generation, also working on seeing how can you kind of take data from scientific literature, kind of provide help online as you kind of look through something. That's the thing that we are working on.
We talked about it in detail last time. Working through this, we thought we'll give you another update, maybe before the end of the year because we are building certain things, and as we kind of see progress, we will provide an update on that.
Siddharth Nigandi
Got it. Got it.
On the peptide one, just if I may add in one more question, on the peptide one, you mentioned about GLP-1s as well as PDCs. You're building capabilities in both or should we look at this as GLP-1s followed by PDCs?
How should one think of your peptide capabilities?
Krishna Kanumuri
No, the comment we made is that peptides go beyond GLP-1. Peptide is a modality that expanded, right?
When we talk peptide, you only talk about GLP-1. Now peptides, look at this year, the three blockbusters peptides which have been launched.
You have the Merck PCSK9, which is for cholesterol, you have basically the Incyte oral peptide which is launched for basically immunology. You're seeing peptides modality going up dramatically with blockbuster potential.
It goes beyond GLP-1. You're seeing PDCs as a big part of the pipeline going forward as well.
What we're saying is we are not solely focused on just the GLP-1 space. We are taking a very big position to be able to support peptides across the therapeutic windows.
That's the comment we're making, so that we're not just chasing a single modality, we're really building broad-based capability in peptides and also with a significant technology platform in peptides.
Siddharth Nigandi
Clear. This will be across discovery, development, and at some point in time, commercial manufacturing?
Krishna Kanumuri
Absolutely.
Siddharth Nigandi
Got it. Thank you, and all the best.
Siva Chittor
Thank you.
Operator
Thank you. Your next question comes from Karan Gupta with Asit C.
Mehta Investment. Please go ahead.
Karan Gupta
Hi. My question regarding the number of molecules that we have in the late stage and the potential revenue out of that.
What will be the completion period of the molecules that we have in the stage, let's say, 1 or 2?
Siva Chittor
We've mentioned this before that the number of exits at phase 1 and phase 2 is fairly huge. Given that while we work on a large set of molecule and we've actually given data as in past more than 150, 160 molecules, we believe we should treat them as projects given the amount of failures that happen at that stage.
That's why we track only late-phase and commercial and present this as data because the probability of success on the commercial side is higher. With respect to the late stage commercialization and potential, I can answer data with respect to commercialization as we know.
As you will appreciate, this is a material non-public information for the pharma companies that are disclosing this information. We also pick up information from publicly available sources, and we presented data for the four molecules that we are aware of, and we've put that as part of I actually talked about it in my speech.
Potential is kind of very difficult to say. We're still in phase 3.
Assuming pharma, you probably should have a decent size, is how otherwise pharma would not pick up a molecule and go to phase 3. That's broadly what we think.
Not able to give you more specific numbers. Okay.
Karan Gupta
Okay. One question on the growth guidance of 15% to 20%, just wanted to have some clarity on this, basically, the number that you said 15% to 20%, how we are come to that 15% to 20% only as we have huge pipeline of late stage 1 and 2 molecules.
Why we are constraint on 15% to 20%, or is the conservative guidance that you are giving? Because sequentially, quarter 1 and quarter 2 quarter 4 and quarter 1, we have slowed down the growth as compared to the previous quarters.
Just wanted to have some clarity on the guidance side.
Siva Chittor
I think one must keep saying this, given how the industry has its own lumpiness in terms of how the business functions, look at the industry in terms of direction we've given a 3- to 5-year guidance of this 15% to 20%. That's really what we've stated.
Now, we are not going to constrain business for growth, right? Look at the last year growth.
While you talked about Q4, if you look at our last year growth, we grew close to 30% on annualized basis. Your shipments and dates of shipment and when your order came and when you need to deliver will decide a quarter's revenue.
I would personally like you to see the business on a longer-term basis. That's when you will actually get to see the trends.
Last year we demonstrated a 30% growth. Our mid-term growth guidance is 15% to 20%.
Is this have I put all my bets on it and every last dollar to get to 15%, 20%? Obviously, we will also want to kind of make sure we will meet and beat guidances that we give to the market.
That's the broader thought process. I will not be able to elaborate this more, Karan, on this one.
Broadly, look at it from a direction perspective and what we are trying to build is our way of looking at it. Okay.
Karan Gupta
Okay. Thank you.
Operator
Thank you. A reminder to all the participants, if you wish to register for a question, please press star and then one.
Your next question comes from Rajat Baldewa with Kizuna Wealth. Please go ahead.
Rajat Baldewa
Hi, sir. Thanks for giving the opportunity.
My question on the
Operator
Sorry to interrupt, Rajat sir, your audio is slightly muffled. If you are using any other mode, I request you to use a handset, please.
Rajat Baldewa
Am I audible now?
Operator
Yes, sir. This is better.
Rajat Baldewa
Thank you for giving the opportunity. My question on the CDMO side.
In this quarter, we have been doing 6% y-o-y. Can you throw some outlook for FY27 and FY28, given that CDMO is a lumpy nature business?
Siva Chittor
We don't split our growth guidance. We've given you a 15% to 20% growth guidance over a mid-term.
As you've rightly pointed out, business is lumpy based on how the deliveries and the purchase orders come in. We've also stated that our H2, the second half of this financial year will be better than the first half, just given more capacity is also coming on stream by the end of Q2 or early Q3.
Rajat Baldewa
Sir. Just a last question, just to confirm, we are in line with our capacity building to reach 1,150 kL by FY27 end, right?
Siva Chittor
Yes.
Rajat Baldewa
Sir. Great, sir.
Thank you very much.
Operator
Thank you. Your next question comes from the line of Thirumala Reddy, an individual investor.
Please go ahead.
Thirumala Reddy
Yeah. Thanks for taking my question.
Hope I am audible?
Siva Chittor
Yes.
Operator
Yes, sir. Please go ahead.
Thirumala Reddy
Is there any particular reason for not entering into monoclonal antibodies or space?
Siva Chittor
It is a strategic question. It's broad as such, yeah.
Krishna Kanumuri
Now, we will discuss the strategy at later point.
Thirumala Reddy
Okay. Thanks a lot.
What is the contribution of this fermentation capacities building in the current capex
Siva Chittor
We don't build fermentation at all.
Thirumala Reddy
Okay. Thanks a lot.
That's from my side.
Operator
Thank you. Participants, you may press star and then one to ask a question.
Your next question comes from Siddharth Nigandi with CWC. Please go ahead.
Siddharth Nigandi
Hi. Thanks for the follow-up.
Just sir, if you could give us some color on how the two offshore facilities in Boston and Manchester are shaping up. Currently, we're obviously seeing the difference in the standalone and consolidated revenue reflecting from one one of those facilities, but if you could give us some color around how are those shaping up and is that commercially adding to our revenues?
Siva Chittor
I think the way to look at Boston and Manchester they're independently at this time I think we mentioned this. I think if you look at the Boston P&L that you would see, it's a bit back-restrict to the business.
The way we look at both Boston and Manchester are satellite centers that help us kind of bring larger business back to India. If, for example, on the discovery side, there has been many instances, one of the reasons we've been consistently growing on the discovery side, and one big reason is that we are able to actually cultivate customers even before they actually have a need for a discovery service or for MedChem or DMPK at a later stage.
We are talking to these customers much before they would need to seek out an Indian operation. By the time you actually help them do a target identification sitting at their backyard, you've probably developed relationship, they understand your business, they understand how your teams function.
I think that kind of gives them that comfort to kind of get business, and that's kind of borne out in the overall numbers, right? We established Boston in somewhere around the end of 2020.
Assuming 2021 was a little bit of washout for COVID, and if you look at the discovery revenue, it's probably in the last 4, 5 years grown at a CAGR of closer around 30%, 35%. On Manchester, I think the skill sets and the requirements are different.
What we've brought in is a set of individuals who worked in large pharma, look at things very differently. I think the way today we look at these two teams function together, but then they bring in very, very complementary skill sets.
Both the teams kind of helped us to be where we are, be it in terms of getting our relationship, be it in terms of deliveries and scale-ups. That's how we look at all of the India and the US teams for the respective businesses as one single team, and they kind of work in tandem.
Siddharth Nigandi
Got it. Thank you.
Operator
Thank you. Participants, to ask a question, please press star and one now.
Your next question comes from the line of Yasir Lakdawala with M3. Please go ahead.
Yasir Lakdawala
Hi, Krishna. Just to sort of get some qualitative sort of understanding, I think when you say that you've got about between 4 4% to 5% of our revenues from new modalities, is it mostly on the CRO side, or are we doing anything on the development and the commercial aspect?
Siva Chittor
We're not doing it on the commercial side, but we are doing on all the development and the discovery side.
Yasir Lakdawala
Development, discovery side, right. Fair enough.
Typically, when we have some biotech customers, and if they're acquired, and in different phases, be it like phase 1, phase 2 by a big pharma company, historically, post-acquisition, does that project necessarily stay with us? What sort of percentage of those projects stay with you?
The big pharmas have their own sort of CDMO networks, and they tend to sort of shift those projects? Just sort of help us understand that.
Siva Chittor
I think Krishna actually addressed this as part of his opening remarks, right? I think one of the biggest advantages that we have is we work with 19 out of the 25 large pharma companies.
Our pipeline today, as Krishna mentioned, right, is growing on three different ways that we're building our CDMO pipeline specifically. We are seeing our biotech customers acquired by pharma companies that we work with that continue to remain in our funnel.
We are seeing pharma companies putting something on the FTE development deals which is in progress into our late-stage funnel. We are also seeing situations where pharma acquired the biotech company with whom we've not worked before, but then the product gets transferred to us primarily because we are one of their preferred vendors.
That's how we work. Finally, just given the pharma relationship, this is what happens.
Yasir Lakdawala
Sure, anyway. Thanks a lot, and wish you guys all the best.
Thanks, Siva.
Siva Chittor
Thank you.
Operator
Thank you. Your next question comes from Dhaval with Jefferies.
Please go ahead.
Hi, sir. Thank you for taking my question.
I wanted to get few more details on the peptide program. Can you inform us how many different projects are we working on within the peptide space, and how many different customers are there?
The facility which is coming up in 2028, that is the pilot-scale facility that you're talking about, or is it something different?
Krishna Kanumuri
Dhaval, this point, majority of the work we are doing is in the early-stage discovery space, multiple customers, significant number of large pharma customers as well as biotech who work with us on peptides. The development lab, we have one lab that's come up dedicated to a pharma company, and there's one much broader facility right now which is coming online which will do GMP pilot supplies for clinical and then will support both development GMP supplies as well as discovery support.
What we're building out for '28 is a true commercial-scale capacity at that point. Clinical capacity is coming online sooner, and commercial capacity is coming online in '28.
Okay. Just I understand, these are still initial years, but based on your experience, what kind of work are customers willing to give on the manufacturing side for peptides?
Are they willing to give out the manufacturing of longer chains, like 8, 10, 12 amino acid kind of chain, or is it restricted to maybe dipeptides or chain length of 4, 5 amino acids? What's your initial sense?
Or is it going to be something that they want to start with smaller chains and gradually are very much willing to take it up into the higher value-chain work?
Krishna Kanumuri
I think it depends on who you ask, right? Right now, because we're doing development technology, people are doing longer chains with us.
If you go commercial, probably people are starting with smaller chains, which are already mature pipelines. We are seeing customers working with us on longer chains right now rather than small chains.
Okay. Just last one on conjugation.
Do you think the next steps on the conjugation side will be to establish a pilot-scale facility, and then if everything goes well, go deeper on a larger scale? Are those the next step if the program continues to do well on the discovery side?
Krishna Kanumuri
We already are building a pilot-scale facility, and we do have more plans there which we will give you more details once we have clearer specifics on the plans we have in terms of that area. We already have a significant footprint we're building, which spans both discovery and development of all XDCs.
Okay. By next year, what would be the total spend that we would have done on the peptide side, let's say towards the end of 2028 when the facility is coming online, ballpark?
Siva Chittor
Dhaval, it's probably going to be less than 300 crores.
Okay. Thank you.
That's it from my side.
Operator
Thank you. A reminder to all the participants, you may press star and then one to ask a question.
Participants, you may press star and then one to ask a question. As there are no further questions from the participants, I now hand the conference call over to the management for closing.
Siva Chittor
Thank you, everyone, for joining the call. Like to reiterate that we continue to remain bullish in the business, and the trajectory that we have set for ourselves, we seem to get validated quarter-on-quarter as we work with our customers.
We continue to believe the path that we're taking with respect to building a development, scientific business that kind of helps us build the science capabilities first before we build the capacity is the right way to go for us. We continue to believe that this will help us deliver value over a longer-term period.
Thank you all for joining the call.
Operator
Thank you. On behalf of Sai Life Sciences Limited, that concludes this conference.
Thank you, everyone, for joining us, and you may now disconnect your lines. Thank you.
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