Celyad Oncology S.A. (Ticker: CLYYF) develops allogeneic CAR T-cell therapies for the treatment of hematological and solid cancers. The company offers proprietary platforms including the allogeneic CAR T technology platform, which engineers non-patient-derived T-cells to avoid graft-versus-host disease; the RNA Switch platform for transient CAR expression; and the Mask platform to mitigate cytokine release syndrome risks. Its lead product candidate, CYAD-101, targets B-lymphoma via NKG2D receptor targeting; CYAD-200 advances off-the-shelf CAR T-cells for colorectal cancer; CYAD-1901 employs RNA Switch for HER2-positive solid tumors; and CYAD-1801 focuses on claudin 18.2-positive gastric cancers. Celyad Oncology operates primarily in Europe and the United States, with headquarters in Mont-Saint-Guibert, Belgium, founded in 2007 as a spin-off from Ludwig Cancer Research. In recent developments, the company completed a merger with 180 Life Sciences in 2024, shifting strategic focus toward fibrosis treatments while retaining oncology assets; announced a reverse stock split and Nasdaq uplisting efforts in early 2025; and initiated a Phase 1 trial expansion for CYAD-200 in combination therapies. Celyad Oncology serves pharmaceutical partners and clinical trial patients in the biotechnology sector, with subsidiaries including Celyad Oncology USA Inc..