- Business
- Cellectis SA is a clinical-stage biopharmaceutical company focused on developing gene-edited allogeneic CAR T-cell therapies for cancer treatment using its proprietary TALEN gene-editing platform. The company engineers off-the-shelf UCART product candidates from healthy donor T-cells, including fully owned lasme-cel (UCART22) targeting CD22 for B-cell acute lymphoblastic leukemia in Phase 1/2 trials with Phase 2 enrollment expected in Q4 2025; eti-cel (UCART20x22) dually targeting CD20/CD22 for non-Hodgkin lymphoma in Phase 1 with readout anticipated late 2025; and licensed programs such as cema-cel (ALLO-501A) targeting CD19 for large B-cell lymphoma in pivotal Phase 2 by partner Allogene; ALLO-316 targeting CD70 for renal cell carcinoma; and IOV-4001 for melanoma and non-small cell lung cancer by Iovance. Founded in 1999 and headquartered in Paris, France, with manufacturing facilities in Paris and Raleigh, North Carolina, Cellectis operates globally through strategic partnerships with Allogene, Servier, Iovance, Primera and AstraZeneca. Recent developments include a $140 million equity investment from AstraZeneca in 2024 providing up to 44% ownership potential and advancing their joint research collaboration agreement initiated in 2023, under which Cellectis received $47 million by year-end 2024 comprising upfront payments, milestones and reimbursements for developing up to 10 novel cell and gene therapies in oncology, immunology and rare diseases; completion of a 40 million euro credit facility with the European Investment Bank in December 2024; and positive end-of-Phase 1 FDA interactions in July 2025 for lasme-cel and eti-cel, bolstering its cash position of $264 million as of December 31, 2024, to fund operations into mid-2027.