Thank you. Thank you all for joining us on today's conference call to discuss EyePoint's first quarter 2026 financial results and recent corporate developments.

With me today is Dr. Jay Duker, President and Chief Executive Officer of EyePoint.

Jay will begin with a review of recent corporate updates and discuss our ongoing clinical programs for DURAVYU in wet AMD and DME. I will close with commentary on the first quarter 2026 financial results.

We will then open the call for your questions, where we will be joined by Dr. Ramiro Ribeiro, our Chief Medical Officer, and Mike Campbell, our Chief Commercial Officer.

Earlier this morning, we issued a press release detailing our financial results and recent corporate developments. A copy of the release can be found in the Investor Relations tab on the company website, www.eyepoint.bio.

Before we begin our formal comments, I'll remind you that various remarks we will make today constitute forward-looking statements for the purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. These include statements about our future expectations, clinical developments and regulatory matters and timelines, the potential success of our products and product candidates, financial projections, and our plans and prospects.

Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including those discussed in the Risk Factors section of our most recent annual report on Form 10-K, which is on file with the SEC, and in other filings that we have made or may make with the SEC in the future. Any forward-looking statements represent our views as of today only.

While we may elect to update these forward-looking statements at some point in the future, we specifically disclaim any obligation to do so, even if our views change. Therefore, you should not rely on these forward-looking statements as representing our views as of any date subsequent to today.

I'll now turn the call over to Dr. Jay Duker, President and Chief Executive Officer of EyePoint.

Thank you, George. Good morning, everyone, and thank you for joining us.

The start of 2026 for EyePoint was marked by a strong quarter of consistent execution as we approach a pivotal inflection point for our lead program, DURAVYU. We have strong conviction that the upcoming LUGANO and LUCIA readouts will catalyze our future transition into a fully integrated biopharmaceutical company, furthering our mission of improving the lives of patients with serious retinal disease.

We remain on track to deliver these Phase 3 top-line data in wet age-related macular degeneration, or wet AMD, beginning mid-year, positioning us to potentially be the first to market among all current investigational sustained release programs. In diabetic macular edema, or DME, we are seeing strong momentum in our Phase 3 program, with enrollment rapidly progressing to support our ambitious goal of full enrollment in both pivotal trials in the third quarter of 2026.

As we advance towards these significant milestones, we are confident that our clinically rigorous, de-risked, and patient-centric approach will continue to reinforce DURAVYU's best-in-class potential in the two largest retinal disease markets. The fundamental strength of the DURAVYU program lies in its robust and differentiated clinical data.

In Phase 2 trials, a single dose of DURAVYU demonstrated durable efficacy with improved vision and tight anatomic control. In over 190 patients across four completed clinical trials, DURAVYU has demonstrated a consistently favorable safety profile with no safety signals.

That profile continues to hold in our ongoing Phase 3 LUGANO and LUCIA trials for wet AMD as observed on a masked basis, where our low discontinuation rate of about 5% remains well below the 10% yearly average typical for wet AMD trials. Importantly, none of these discontinuations were related to treatment.

At this stage, all patients across the LUGANO and LUCIA trials have reached the Week 32 visit, during which patients in the DURAVYU arms received their second DURAVYU dose. Over 35% of those patients have since received their third planned dose of DURAVYU at Week 56.

As a reminder, we've received two consecutive positive recommendations from the independent Data Safety Monitoring Committee, with the third review scheduled for later this month. We are optimistic that the interim masked safety data will continue to remain consistent, further strengthening DURAVYU's clinical profile.

In addition, we believe the multi-mechanism of action, or MOA, of DURAVYU's active ingredient, vorolanib, will prove to be a key clinical differentiator. Along with blocking all VEGF isoforms and PDGF at the receptor level, preclinical data supports vorolanib's ability to inhibit IL-6 signaling via the JAK1 receptor.

With this unique ability to not only address both the vascular leakage and inflammation that contributes to retinal disease pathogenesis, but also potentially provide sustained release efficacy, DURAVYU is uniquely designed to deliver wide-reaching therapeutic potential. Earlier this week, we presented peer-reviewed data at the Association for Research in Vision and Ophthalmology, or ARVO meeting, that reinforces these findings and further substantiate DURAVYU's potential to improve long-term outcomes for patients.

A primary kinase screen and subsequent measure of IC50 levels identified vorolanib as a potent inhibitor of JAK1, which plays a critical role in IL-6 mediated inflammation. In addition, vorolanib proved to be a potent inhibitor of IL-6 leakage in an in vitro cellular model.

This data further highlights the multi-MOA potential of DURAVYU, with the opportunity to bring a synergistic anti-inflammatory effect in addition to established VEGF and PDGF inhibition to the treatment of wet AMD and DME. As we near top-line data for our Phase 3 wet AMD program, it's worth remembering the key elements underpinning its thoughtful design.

Our approach is de-risked, following an established non-inferiority regulatory pathway. Both pivotal trials are identical, and compare DURAVYU to on-label 2 mg aflibercept, which is intended to reflect real-world practice and generate clinically relevant data to inform the retina community.

Additionally, both trials are evaluating six-month redosing and statistical superiority in treatment burden reduction to support the potential for a compelling label that addresses the need for effective, durable disease control. Taken together, we believe our Phase 3 program is well-positioned to deliver data that will build upon our positive clinical development track record and contribute to strong commercial positioning for DURAVYU, if approved.

We look forward to reporting top-line data from our Phase 3 wet AMD trial LUGANO this summer, with our second trial LUCIA to follow shortly thereafter. We are applying the same de-risked approach to our Phase 3 DME program, which leverages a non-inferiority design, an on-label 2 mg aflibercept control, and redosing every six months.

Similar to our wet AMD program, we designed our pivotal trials for DME based on impressive data from the Phase 2 VERONA study, in which DURAVYU demonstrated rapid efficacy with 4 to 5 letters of vision improvement and approximately 50-micron improvement in anatomic control compared to aflibercept at Week 4. Both of our DME trials, COMO and CAPRI, are now underway with over 1/3 of patients enrolled across both trials, following first patient dosing at the end of February of this year.

Our strong pace of enrollment is driven by our ability to leverage our pre-existing clinical trial infrastructure and investigator network, as well as the significantly smaller trial size compared to our wet AMD program. We expect top-line data in the second half of 2027.

Stepping back, both wet AMD and DME together represent the vast majority of the global branded retinal disease treatment market, with a combined branded opportunity totaling nearly $15 billion in the U.S. and growing.

Through exceptional clinical leadership and commitment to serving the retinal community, we are positioning DURAVYU to become a durable franchise with blockbuster potential. With a unique multi-MOA, robust clinical data package, proven delivery technology, the ability to be shipped and stored at ambient temperatures, and administration via standard in-office intravitreal injection, DURAVYU represents a compelling and truly innovative product profile that has the potential to reshape the treatment paradigm for serious retinal diseases.

We continue to make significant strides in our commercial readiness while remaining disciplined in our investments as we prepare for regulatory submission. We have thoughtfully grown our organization with the addition of Michael Campbell as Chief Commercial Officer last quarter, in addition to expansion across key areas such as marketing and market access, regulatory, compliance, and medical affairs, to build on our organizational capabilities as we advance our launch planning and strategy for DURAVYU in wet AMD.

In addition to progress on our commercial readiness activities, we continue to prioritize CMC readiness. Our cGMP facility in Northbridge, Massachusetts has been online for over a year, supporting our plans for an anticipated CMC submission for our potential new drug application, or NDA, as well as for commercial supply, if approved.

We continue to prepare for pre-approval inspection, underscoring our growing independent commercial readiness that we believe will ensure preparedness to deliver DURAVYU to patients upon potential approval. Before passing it over to George to review the financials, I'd like to thank the entire EyePoint team for your unwavering commitment to improving the quality of retinal care.

We are proud to support the retina community and grateful to the patients, study coordinators, and clinical investigators who enable our research. We look forward to our upcoming Phase 3 wet AMD readouts, together with continued progress in our DME program, which we believe sets the stage for meaningful value creation at EyePoint.

I will now turn the call over to George.

Thank you, Jay. As the financial results for the three months ended March 31st, 2026 were included in the press release issued this morning, my comments today will be focused on a high-level review for the quarter.

Importantly, we continued our disciplined financial management and good stewardship of our resources, ending the first quarter with $223 million in cash and investments. For the quarter ended March 31st, 2026, total net revenue was $0.7 million compared to $24.5 million for the quarter ended March 31st, 2025.

The decrease was primarily driven by the recognition of remaining deferred revenue related to the company's agreement in the second quarter of 2023 for the license of YUTIQ product rights. Operating expenses for the quarter ended March 31st, 2026 totaled $88 million compared to $73 million in the prior year period.

This increase was primarily driven by the ongoing Phase 3 trials for DURAVYU in both wet AMD and DME and the scale-up of our Northbridge commercial manufacturing facility. Net non-operating income totaled $2 million, and net loss was $85 million, or 99 cents per share, compared to a net loss of $45 million, or 65 cents per share, for the prior year period.

As I noted earlier, cash, cash equivalents, and investments in marketable securities on March 31st, 2026 totaled $223 million compared to $306 million as of December 31st, 2025. We continue to expect that our current cash position will enable us to fund operations into the fourth quarter of 2027, beyond key milestones for the Phase 3 wet AMD program expected later this year.

In conclusion, we're pleased with EyePoint's progress so far in 2026 and remain well-capitalized to deliver DURAVYU through key value-driving milestones in the two largest retinal disease markets. I will now turn the call back over to Jay for closing remarks.

Thank you, George. As we continue to deliver on our key priorities for 2026, our team is focused on advancing preparations for the pivotal Phase 3 top-line data readout in wet AMD expected mid-year and completing enrollment of our Phase 3 DME program in the third quarter of this year.

We believe TKIs represent the next frontier in retinal disease innovation, and we are proud to be advancing DURAVYU as a potential first and best-in-class option in the two largest retinal disease markets. Thank you all for your attention this morning.

I will now turn the call back over to the operator for questions.

Great. Thanks so much.

Hey, guys. Thanks for taking our question this morning.

Just one from us on the DME side, actually. For your COMO and CAPRI trials, you talked a bit about your swift pace of enrollment here.

Can you speak to what you're hearing from the investigators in terms of the level of interest from both patients and physicians around a TKI sustained delivery treatment option like DURAVYU? What are the key differences and similarities that you hear in the DME space versus maybe what you've heard in the wet AMD space?

Thanks so much.

Thanks for the question, Tess. Given that our CMO, Ramiro Ribeiro, is really at the forefront of this, [cough] I'll ask him to answer your question.

Hey, Tess. Good morning.

Thanks for the question. First, as you mentioned, we are seeing a great excitement around our DME program COMO and CAPRI with a quite quick enrollment so far.

We are now leveraging all the infrastructure that we use for our wet AMD with our clinical sites and our CRO and vendor as well. The feedback that we're getting from investigators, very similar to our wet AMD, is that our study is a very patient-centric study trying to address a very important unmet need, which is the treatment burden.

Patients that are participating in this study are very excited for a therapy that can last for about six months. In particular, for the DME indication, we know that the need for this patient population might be even greater than wet AMD.

This is a patient population that is relatively younger, and they are still in the workplace. A therapy that can reduce the number of visits like DURAVYU is, of course, of very interest for this patient population.

Again, I think the excitement both from the investigators, the patient, clinical sites is being reflected in the pace of our enrollment.

I'd like to add just one more thought to this. We invited 90 of our wet AMD investigators to be investigators in the DME trials, and all 90 accepted.

We believe that continues to show investigators' enthusiasm for the potential of DURAVYU.

Great. Thank you very much for taking the questions.

I'm just wondering if you could comment on how the supplement trigger criteria are functioning in the Phase 3 trial relative to the Phase 2 trial, the DAVIO 2 trial, and if you could also comment on what you would expect to be a meaningful supplement rate in the Phase 3 trial that would be consistent with a strong commercial uptake. Thank you.

Yigal, nice to hear from you. Thanks for the question.

With respect to supplements, I'm going to have Ramiro comment in a moment about how that is working in the trial. I think there's really two issues around the supplementation that people should understand.

The first is that in the clinical trials, supplements will be handled statistically as sensitiv- with sensitivity analyses that we will be doing when we submit the NDA. There is a rate of supplements, at least conceivably, of above which the drug would not be considered to be working independently because of a high rate of supplements.

In saying that, the FDA has never put a line in the sand as to what that level would be because they want to see the totality of the data. They want to see the safety and the efficacy otherwise.

From a supplementation perspective, there is an important hurdle which, of course, we need to get over, which is the non-inferior margin, which is the primary endpoint. If we are approved, then I think the commercial acceptance shifts to a very different place.

In the real world, a supplement is not a failure. Doctors, I believe, if we are approved, will enjoy taking advantage of using two MOAs to help [unclear] That's been true across a lot of chronic diseases, where if two MOAs in treatment are available, using them synergistically is a potential advantage to patients.

Now obviously, we haven't shown that yet in our trials, but we hope that that would be the case for the benefit of patients. My point about supplements in the real world, I'll give you again an example: if I've got a patient that I have to inject every two months with a biologic anti-VEGF, and let's hypothesize that DURAVYU is FDA approved, it's safe, it's tolerable, and has a label for every six months, and the patient gets shifted to DURAVYU for the next year with two injections, but in addition, they receive two injections of a biologic, well, it's a great win for everyone.

The patient can go from every two months to every three months, from six injections to four injections, and that presumably the advantages of DURAVYU will be aligned with the patient and the doctor's interest. There's the regulatory hurdle that needs to be reached over supplements, and if that's reached, I believe that supplementation in the real world will have great latitude for acceptance.

Thank you. Then if I could just ask one other follow-up on DME.

Of course, you mentioned IL-6 as a potentially interesting biomarker. Are any of those IL-6 biomarker endpoints formally embedded in the Phase 3 DME program as sort of secondary endpoints that could help differentiate the product?

I would say yes, but indirectly. Given that there is no way to measure in a patient in a clinical trial the direct effects on IL-6 or JAK1, we would be measuring the indirect effects.

The indirect effects, of course, number one is visual acuity. What we hope to be doing in the long term is provide better visual acuity for patients.

In DME, we may be able to provide it in the short term. Again looking at the VERONA data, at Week 4, the patients who received DURAVYU had better vision and drier retinas as early as Week 4 compared to a single dose of aflibercept.

We have set up the COMO and CAPRI trials to try to show that, and there is a secondary endpoint of visual acuity and OCT at Week 4, given our drug is given at Day 1 in the DME trials. That we hope to show that even if we're non-inferior and equivalent to EYLEA, but we can provide the benefit earlier with fewer injections, then we will be able to have great advantage to patients and therefore a commercial success.

There are other secondary endpoints that we can look at that are not direct measurements of IL-6 or JAK inhibition, for example, leakage on fluorescein angiography. You may recall that in the VERONA trial, we had a significant reduction in leakage as measured by an independent reading center, and it was dose-dependent, with the higher dose of 2.7 mg showing much greater leakage reduction compared to the lower dose and compared to the aflibercept control.

That's the kind of secondary endpoint that if we can show reduction in leakage greater than aflibercept, I think the evidence would lead to that is due to IL-6 inhibition.

Thanks.

Hey, guys. Thank you for taking the question.

Just wanted to ask in the ongoing wet AMD studies, are you guys able to see blinded rescue rates and are those tracking in line with your expectations? Thank you.

Thanks for the question, Faisal. Again, I'll let Ramiro talk about the supplementations and what we're seeing and what we're not seeing.

Hey, Faisal. Thanks for the question.

We there's a very small team at EyePoint that reviews the supplementation injections, and essentially to make sure that the clinical sites are following the protocol. We don't review aggregated supplement injection rate, and that's something that we don't disclose publicly.

Makes sense. Thanks for taking the question.

If I may add, we again, as Ramiro indicated, have no insight into the number of supplements, supplementation rate, etc. at this point.

It's all masked. We do anticipate that the supplementation rates in the Phase 3 trials will be less than what we saw in the Phase 2 for several reasons, again, due to the tightening of the supplement criteria, getting rid of the physician discretion in supplements, the reinjection at Month 6, and the inclusion of the majority of naive patients.

All of those together should result in fewer supplements in Phase 3.

That's helpful context. Thank you.

Hey, guys. This is Eddie on for Yatin.

Thank you for taking my question. Thinking about the fixed-dose regimen that you guys are going after, are patients who are already dry with stable vision still receiving that third dose at Week 56?

If so, is there any incremental safety signal from redosing well-controlled patients? Further, has the FDA weighed in on how this complicates the retreatment redosing schedule?

Thank you so much.

Thanks, Eddie. [cough] Very good question.

Yes, this is a fixed-dose regimen. It has nothing to do with whether the patient at the time of their repeat dose of DURAVYU is dry or wet or what the visual acuities are.

Just like any drug, for example, take 2 mg EYLEA, when it was first studied every two months, that was fixed dose where they received that injection whether they were active or not. That's going to be true in our trial.

From the perspective of safety, we've done extensive preclinical safety in animals, and in rabbits, we never found the maximally tolerated dose of vorolanib, and we've injected scaled dose of about 10 times higher than anything we could achieve in humans. We've also not found the maximally tolerated number of inserts in rabbits.

From a safety perspective, we were not concerned about reinjection. Again, we are reviewing the masked safety, and I will once again turn to Ramiro if he wants to comment on the upcoming DMC meeting that is going to be occurring shortly.

No, thanks, and thanks, Eddie, for the question. We, as Jay mentioned, safety is something that is, of course, paramount for EyePoint, and we conduct ongoing safety review of the data.

If you do the math, we have now had patients that reached that Week 56 visit that you mentioned, which is the third dose of EYP-1901, and we haven't seen anything different than what we saw before. We do have an upcoming DMC meeting the month of May, where the members will review unmasked data, and we look forward to provide updates after that meeting.

Great. Thank you.

Hi. Thanks for taking my question.

What have you seen in the masked safety data set so far, and has anything shifted your expectations going into the DSMB review that is scheduled for late May?

Thanks for the question, Debanjana. We're not commenting on any individual SAEs or AEs, but in total, I would say, and repeat what Ramiro said, what we've seen so far is consistent with what we have seen in the prior four trials, no new safety concerns, and no incidents that we haven't seen or expected from before.

Again, Ramiro, I don't know if you want to add any more color to what I said.

No, I think just again to reiterate, safety at EyePoint is paramount. We internally review the data on an ongoing basis on a masked fashion.

As Jay mentioned, we have no safety signal, we haven't detected anything that is new. This safety profile continues to be very similar to what we saw in our previous completed studies.

Thank you. Just a very quick follow-up.

Can we expect any form of public update following the DSMB meeting?

Yes, I think it's likely that we will give an update. Yes.

Great.

Thank you. Fall back in the line.

Bye.

good morning. Thanks for taking our question and congrats on the progress.

We have seen a long-acting TKI competitor have a successful readout of their pivotal study earlier this year. We've heard their plan is to file with the FDA and seek approval on this trial alone.

In a scenario where essentially both yours and the other long-acting TKI are being launched within similar time frames, does perhaps having two products with the same mechanism of action actually help break into a market which already has an established therapeutic base with the anti-VEGF? How should we think about this?

Thanks again.

Lisa, thanks for the question. It's a great question, and I think you've really hit on a very important point.

This is not a zero-sum game. The TKIs are going into a multi-billion dollar market, and there is certainly room for two competitors to both be very successful in this very large market.

There is evidence from, as I think you're alluding to, from other launches with new mechanisms of action into an established space that having more than one entry really helps both because doctors are hearing it and learning about it from multiple places. We welcome another competitor and part of that is we believe we've got a better drug and a better delivery system, and hopefully, if both are FDA approved, we will have the opportunity from a commercial basis to really show that.

Thanks for taking my question. Appreciate the feedback.

Thanks, Lisa.

Hey, everyone. It's Nick on for Colleen.

Thanks for taking the question. At ARVO and other recent scientific conferences, just wanted to ask what the takeaways were on DURAVYU sentiment among physicians, and if you got any learnings about how physicians intend on using DURAVYU upon a potential approval.

Thank you.

One point I'd like to make, and thanks for the question, Nick, one point I'd like to make about ARVO is we had a poster there which showed another preclinical model of leakage induced by VEGF and IL-6. In that model, vorolanib, the active ingredient in EYP-1901, was able to suppress the inflammation induced by IL-6 and VEGF equal to an anti-VEGF and an anti-IL-6.

Again, one more model that suggests that vorolanib does have potent anti-IL-6 activity through the JAK1 receptor. There was a lot of interest in that poster, a lot of KOL saw it, and there were quite a number of comments.

Ramiro met with multiple KOLs at ARVO, and I will let him weigh in on what the sentiment seems to be around EYP-1901.

No, thanks, Nick, for the question. We had a very productive ARVO this year with several poster being present presented, including the one that Jay just mentioned.

We also had a few advisory board and some interactions with our Phase 3 wet AMD and DME investigator. I think first on the sentiment of the clinical trials, I think everybody, of course, is very excited for the upcoming data for LUGANO and LUCIA, mentions of, this is going to be the highlight of the retinal space for the year of 2026.

For DME, the investigators, again, reflect that this is a really well-studied plan, very patient-centric, and they were all excited about bringing the the therapy for patients with DME. In terms of of future use of of DURAVYU, as Jay mentioned previously in the call, they express the important unmet need that we're trying to address with DURAVYU.

They see this, if we can replicate the results that we saw in the Phase 2 study, as something that is going to be very meaningful for patients, especially for those patients that require frequent treatment.

Great, thanks, all. Thanks for taking the question.

Congrats on the progress.

Thank you.

Good morning, and thanks for taking the questions. I just follow up a little bit on the commercial question earlier, which is that besides the TKIs in terms of the long-acting biologics, the VABYSMO and the high dose EYLEA, which one or you think you DURAVYU, if approved, will be competing more or less?

Any comments on that? Thanks.

Thanks for the question, Yale. It's an important question because these are excellent medications that are multi-billion dollar drugs that are really helping many, many patients.

I think the first point to be clear on is we're not another anti-VEGF biologic. We work at the receptor level.

We have multi-MOA: block VEGF, PDGF, and we do believe the inflammation related to IL-6 elevation, which is not something that they do. In addition, it looks like from our Phase 2 data that at least 2/3 of the wet AMD population could be treated with our drug alone every six months should physicians choose to do that.

That's not something that we're seeing in the real world with those new medications. While there are extended durations, well, the real-world data is suggesting that most patients are getting about a week or two extension from either of those drugs compared to what they were on before.

Now, that's great, but we still believe that it leaves a lot of room in the market for a six-month or longer medication. It's hard to predict which of those drugs will be, I don't want to say the winner because I think both drugs are doing well, when we launch potentially.

Again, our belief is that we can provide benefit greater than what either of those drugs can do for patients. We believe in the long term, we will achieve better visual acuity.

Mike Campbell, our Chief Commercial Officer, I believe is on the line, and I don't know if he's going to maybe have any other comments. Now I think it's a little early to talk about commercial strategy, but maybe, Mike, you can talk a little bit about how you view the competition.

Thank you for the question. The one point I would add is that while we have these very good anti-VEGFs, longer-acting anti-VEGFs in the market, not only is the real-world data showing the extension that Jay mentioned, around 8 8 days, we also look at what the retina specialists are saying in the community and where the needs are.

If you look at the American Society of Retina Specialists, ASRS, every year, they put out a PAT survey. Very consistently, the number one need in wet AMD treatments that is reported from ASRS is still durability, even with VABYSMO and EYLEA HD in the market.

To Jay's point, there is a very clear opportunity, should DURAVYU be successful and be approved, there's a very clear opportunity for room in this market for more durable agents.

Great. Thanks a lot.

Hi, guys. This is Sam on for Tara.

Can you hear me?

Yes. Hi, Sam.

Great. Thanks for taking our question and congrats on another great enrollment update.

I just wanted to ask on safety for the LUGANO data and if you could help us set some expectations there for what you're hoping to see. I guess besides avoiding some of the more serious back of the eye events, are there any other AEs where you think DURAVYU could be differentiated versus competitors?

Then also, it'd just be great if you could clarify how you are anticipating to disclose those safety data in the top-line release. Will you be reporting all events or just those above a specific threshold?

Thanks.

Thanks for the question, Sam. Again, one of the hallmarks of the current anti-VEGF approved drugs, with, perhaps one exception, is they're quite safe.

While patients and physicians will probably be willing to accept a perhaps a few more AEs from a long-acting drug, there can't be a big difference. There's really a high bar that's out there for safety.

The good news is that all our safety from our four reported trials shows no real increase in any [cough] SAE or AE that would preclude our drug from being widely accepted, in our opinion. From a safety perspective, again, a lot of the safety issues that can occur are injection related.

If you're reducing the number of injections that a patient gets, then you're likely, in the long term, to have fewer adverse events. [cough] We hope to be able to show that in our pivotal trials.

From a reporting perspective, I don't know how granular the safety reporting will be initially, but we do expect to have complete AE tables when we present the data from LUGANO and LUCIA.

Got it. Very helpful.

Thank you.