F-star Therapeutics, Inc.
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- F-Star Therapeutics, Inc. (FSTX) is a clinical-stage biopharmaceutical company focused on developing next-generation multispecific immunotherapies, particularly tetravalent mAb2 bispecific antibodies and STING agonists, to treat cancer patients with limited options by reactivating the immune system against tumors. Founded in 2002 and headquartered at the Babraham Research Campus in Cambridge, United Kingdom, the company engineers its proprietary modular antibody technology to enable simultaneous targeting of immune checkpoints and costimulatory receptors; its lead clinical pipeline includes FS118, a first-in-class LAG-3/PD-L1 bispecific antibody in Phase 2 proof-of-concept trials for PD-1/PD-L1 acquired resistance head and neck cancer and checkpoint-naïve non-small cell lung cancer plus diffuse large B-cell lymphoma; FS120, a first-in-class OX40/CD137 dual agonist bispecific antibody in Phase 1 trials to enhance standard-of-care outcomes; FS222, a CD137/PD-L1 bispecific antibody in Phase 1 trials targeting PD-L1 low tumors; and SB 11285, a second-generation intravenous STING agonist in Phase 1 monotherapy and combination studies with atezolizumab. F-Star operates primarily in Europe and the United States through its clinical programs and maintains partnerships with multinational pharmaceutical companies, including a recent license agreement with Takeda for a novel immuno-oncology bispecific antibody. In a major strategic shift, invoX Pharma, a subsidiary of Sino Biopharmaceutical, completed its $161 million acquisition of F-Star in March 2023 to bolster its oncology pipeline, but F-Star transitioned to operate as an independent private company by early 2025, enabling focused advancement of its differentiated bispecific platform amid ongoing Phase 1 and 2 trials.
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