- Business
- Sangamo Therapeutics, Inc. (Ticker: GBY.DE) is a clinical-stage genomic medicine company that develops gene therapies, gene editing, and gene regulation technologies for the treatment of neurological diseases, hemoglobinopathies, and immunodeficiencies. The company offers a pipeline of product candidates including ST-920 (isaralgagene civaparvovec), a zinc finger nuclease-based gene-edited therapy for Fabry disease; TX200, a CAR-Treg cell therapy for kidney transplant rejection; and SB-525 (giroctocogene fitelparvovec), an AAV6 capsid-delivered gene therapy for hemophilia A developed in collaboration with Pfizer Inc. Additional programs encompass zinc finger protein transcription factors (ZFP-TFs) for prion disease and gene regulation platforms for other monogenic diseases; services include genomic medicine discovery and development using proprietary zinc finger nuclease (ZFN) and ZFP technologies. Sangamo operates primarily in the United States and Europe, targeting patients with rare genetic disorders through partnerships with pharmaceutical companies such as Pfizer, Novartis, and Kite Pharma (a Gilead Sciences subsidiary). Founded in 1995 and headquartered in Brisbane, California, the company maintains subsidiaries including Sangamo Therapeutics UK Ltd. and Sangamo BioSciences Inc. In recent developments within the last two years, Sangamo completed a strategic restructuring in 2024, including a significant reduction in workforce and pipeline prioritization to focus on neurology assets like ST-920 following positive Phase 1/2 data; entered a collaboration with Genentech (Roche) in 2024 for ZFP-TF-based therapies in neurology; licensed its capsid portfolio to Lilly in 2023 for AAV delivery technologies; and announced topline results from the STAAR study for Fabry disease in mid-2025, supporting regulatory filings.