- CEO
- D. Lynn Kirkpatrick
- Full Time Employees
- 10
- Sector
- Healthcare
- Industry
- Biotechnology
- Address
- 7946 Ivanhoe Avenue La Jolla CA United States of America 92037
- IPO Date
- Jun 30, 2021
- Business
- Ensysce Biosciences, Inc. Ensysce Biosciences, Inc. (NASDAQ:ENSC) (ENSCW) is a clinical-stage biopharmaceutical company that develops proprietary prodrug technologies to create safer oral prescription medications for severe pain relief while minimizing risks of opioid misuse, abuse, and overdose. The company leverages its Trypsin Activated Abuse Protection (TAAP) platform, which employs a two-step activation mechanism requiring specific intestinal enzymes to prevent abuse via snorting, injection, chewing, or extraction; and its Multi-Pill Abuse Resistant (MPAR) platform, which incorporates a trypsin inhibitor like nafamostat to block overdose potential even if multiple pills are ingested orally. Its lead product candidate, PF614, is an extended-release oxycodone prodrug utilizing TAAP technology with FDA Fast Track and Breakthrough Therapy designations for treating severe pain; PF614-MPAR combines PF614 with MPAR for added oral overdose protection; and nafamostat is also advanced for potential use in treating infections and pulmonary diseases. Founded in 2003 and headquartered in La Jolla, California, Ensysce Biosciences operates primarily in the United States with a focus on the pain management and opioid crisis markets targeting patients, healthcare providers, and regulators concerned with prescription drug safety. In recent developments, the company announced a strategic partnership in December 2024 for the development and commercial launch of PF614 and PF614-MPAR; accelerated the PF614-MPAR-102 clinical study with full enrollment of Part 2; completed a $5 million financing round and secured a $14 million multi-year grant in 2024; received positive FDA feedback in November 2025 on the PF614 manufacturing approach; showcased its technologies at PAINWeek 2025 and the Pain Therapeutics Summit; and plans to submit a New Drug Application for PF614 by 2026 with commercialization targeted for year-end, subject to additional funding.