Operator
Greetings, and welcome to Azenta Q2 2026 fiscal financial results. During the presentation, all participants will be in listen-only mode.
Afterwards, we will conduct a question-and-answer session. If at any time during this call you require immediate assistance, please press *0 for the operator.
As a reminder, this conference is being recorded Wednesday, May 6, 2026. I will now turn the conference over to Yvonne Perron, Vice President, FP&A and Investor Relations.
Please go ahead. Greetings, and welcome to Azenta Q2 2026 fiscal financial results.
During the presentation, all participants will be in listen-only mode. Afterwards, we will conduct a question-and-answer session.
As a reminder, this conference is being recorded Wednesday, May 6, 2026. I will now turn the conference over to Yvonne Perron, Vice President, FP&A and Investor Relations.
Yvonne Perron
Thank you, operator, and good morning to everyone on the line today. We would like to welcome you to our earnings conference call for the second quarter of fiscal year 2026.
Our second-quarter earnings press release was issued yesterday after market and is available on our Investor Relations website located at investors.azenta.com, in addition to the supplementary information and PowerPoint slides that will be used during the prepared remarks today. Please note that effective the first fiscal quarter of 2025, the results of B Medical Systems are treated as discontinued operations.
I would like to remind everyone that during the course of the call, we will be making a number of forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. There are many factors that may cause actual financial results or other events to differ from those identified in such forward-looking statements.
I would refer you to the section of our earnings release titled Safe Harbor Statement, the safe harbor slide on the aforementioned PowerPoint presentation on our website, and our various filings with the SEC, including our annual reports on Form 10-K and our quarterly reports on Form 10-Q. We make no obligation to update these statements should future financial data or events occur that differ from the forward-looking statements presented today.
We may refer to a number of non-GAAP financial measures, which are used in addition to and in conjunction with results presented in accordance with GAAP. We believe the non-GAAP measures provide an additional way of viewing aspects of our operations and performance, but when considered with GAAP financial results and the reconciliation of GAAP measures, they provide an even more complete understanding of the Azenta business.
Non-GAAP measures should not be relied upon to the exclusion of the GAAP measures themselves. On the call with me today is our President and Chief Executive Officer, John Marotta, and our Executive Vice President and Chief Financial Officer, Lawrence Lin.
We will open the call with remarks from John, then Lawrence will provide a detailed look into our financial results and our outlook for fiscal year 2026. We will then take your questions at the end of the prepared remarks.
With that, I would like to turn the call over to our CEO, John Marotta.
John Marotta
Good morning, everyone, and thank you for joining us today for our second-quarter earnings call. Candidly, we are not satisfied with our second-quarter results.
Overall, second-quarter organic revenue was down 3% and adjusted EBITDA margin of 5.4% did not meet our expectations. While our teams remain disciplined and are delivering progress in key areas, there have been execution-related shortfalls within our control, and we are addressing them with urgency.
At the same time, we are operating in a more cautious, prolonged demand environment, particularly in North America, where customer spending and research funding remain constrained. Within that context, we saw continued growth in multiomics in Europe and in Asia.
In addition, Sample Repository Solutions, product services, and consumables and instruments delivered sustained growth, reflecting the strength of our recurring revenue offerings. This performance reinforces the durability of these parts of our portfolio and their role in supporting more consistent results over time.
Turning to specific drivers of the second-quarter performance. In multiomics, while both Europe and Asia-Pacific volumes remain strong, performance was driven by softer demand across key end markets in North America and competitive pressure, resulting in lower volumes and reduced fixed cost absorption.
In Sample Management Solutions, we remain pleased with Sample Repository Solutions performance that remains strong, delivering solid growth and reinforcing the value of our recurring revenue service-based model, as did product services and consumables and instruments. This was offset at a segment level by continued softness in automated and cryogenic store systems that reflected a more pronounced step-down in capital-related demand.
With respect to the automated stores quality issues, there are three remaining stores where remediation is progressing, but is taking longer than anticipated. The scope of the quality issues has not changed, and now we expect the remaining work to be completed by the end of the third quarter.
As a result of these pressures, we have revised our full-year fiscal 2026 outlook and have taken a cautious approach to assessing our pipeline as order conversion remains less predictable. The life sciences funding environment remains measured, with ongoing variability in academic and government-related funding flows, including NIH-related activity, as well as more selective capital deployment across biotech and pharma customers.
We now expect organic revenue to range from down 2% to up 1% year over year, reflecting a prolonged period of constrained capital deployment for larger automated stores and cryo investments, as well as continued demand softness in multiomics in North America. Adjusted EBITDA is expected to range from down approximately 125 basis points to flat year over year, reflecting the impact of lower volumes.
Importantly, we continue to invest in targeted growth and productivity initiatives as part of our broader transformation agenda. In a lower-volume demand environment like this, operational inefficiencies and execution gaps become more visible and have a greater impact on results.
We are addressing these gaps to ensure that the business is structurally efficient, scalable, and positioned to deliver higher and more consistent performance over time, with greater precision, stronger discipline, and clearer accountability. While these challenges impact our near-term results, they reinforce the need for the work already underway to transform Azenta.
Since I joined the company, we've undertaken decisive steps to structurally reposition the business for improved performance. These actions include leadership changes, organizational redesign, deployment of the Azenta Business System to strengthen operational rigor, and a more disciplined long-term assessment of portfolio performance and growth investments.
Operational excellence remains central to how we run the business, and we're seeing tangible results from the Azenta Business System. In our consumables and instruments business, on-time delivery has improved significantly, from approximately 50% to 70%, reflecting stronger execution and greater reliability for our customers.
In multiomics, we're also driving meaningful improvements in turnaround times. With our Lightning RNA-seq offering, we've reduced turnaround time from roughly 20 days to 5 days, which is the fastest turnaround time currently available in the market and a meaningful differentiator for our customers that just launched.
These gains are being driven through Kaizens and structured problem solving, as well as daily management systems. ABS positions us to deliver more consistent, high-quality performance.
In 2025, our focus was on reshaping Sample Management Solutions. Today, SMS has a more stable operating base and a stronger foundation for execution.
In 2026, we've shifted our focus to multiomics, where we are actively executing a comprehensive transformation of the business, in addition to addressing the demand softness through targeted commercial actions. As this work has progressed, we have gained more clarity as to what is required to strengthen execution and drive sustainable performance.
We are excited that Trey Martin has joined Azenta as the President of the Multiomics business to lead this transformation, advancing our gene synthesis regionalization and technology strategy, strengthening commercial discipline, and driving structural improvements. Trey brings over 30 years of experience leading and scaling life sciences businesses, most recently as CEO and board member of Maravai LifeSciences, with prior senior leadership roles at Danaher, including President of Integrated DNA Technologies, where he drove global expansion, strong commercial execution, and sustained double-digit growth.
Trey is exceptionally well positioned to lead the next phase of our multiomics strategy. I'm confident in his ability to lead us forward.
Trey and his team are working to accelerate progress across key initiatives. This includes reviewing our site and laboratory footprint to optimize the hub-and-spoke model and right-size the cost structure, strengthening commercial excellence with a greater focus on high-value workflows, improving pipeline conversion, and disciplined execution of commercial opportunities, driving operational productivity by accelerating ABS deployment, and implementing the technology and infrastructure to strengthen our competitive positioning.
This is not an incremental change, but rather a structural overhaul of the multiomics platform. While we navigate this environment, we continue to deliver strong free cash flow and maintain a solid balance sheet with significant financial flexibility to support our strategy.
Our capital allocation framework remains disciplined and unchanged. Our priorities are investing in productivity and gross margin improvement, driving organic growth through R&D and go-to-market capabilities, pursuing disciplined and strategic M&A, and returning capital to shareholders when appropriate.
In March, we announced the acquisition of the UK Biocentre Limited, and the integration is progressing as planned. The acquisition strengthens our ability to deliver end-to-end life cycle solutions in the UK, a leading life sciences research epicenter, while expanding our presence in Europe by establishing UK Biocentre as a European-wide operational hub to support pharmaceutical, biotechnology, academic, and public health customers across the region.
The acquisition is aligned with our biorepository expansion strategy and further strengthens our leadership in sample-based and biorepository solutions. Integration priorities include hiring key commercial resources, accreditation, and operational readiness.
This acquisition demonstrates our commitment to investing behind our highest-conviction, long-range plan initiatives. We also recently provided an update on the previously announced B Medical transaction.
As of March 27, 2026, we were informed by the counterparty that it had not yet secured the required financing to complete the transaction by the expected closing date of March 31st. The agreement remains in place and continues to be subject to customary closing conditions, including financing.
We are actively evaluating potential paths forward while the counterparty continues its financing process. We will provide updates as appropriate.
As previously announced, we continue to evaluate the timing of execution under our $250 million share repurchase authorization, reflecting our commitment to disciplined capital deployment and shareholder value creation. To close, given the guidance reset this year, we have decided to push out the long-range plan we outlined at our Investor Day in December of 2025 by one year, from 2028 to 2029.
The same financial targets remain, and we believe that the market opportunities, strategic priorities, and value creation framework are strong. I want to emphasize our confidence in the long-range plan, anchored in the strength of our portfolio and our ability to expand our recurring revenue base that supports more consistent and durable performance.
Across the organization, we are operating with greater focus, stronger discipline, and higher accountability and clearer execution priorities. With that, I'll turn the call over to Lawrence to walk through the financials.
Lawrence Lin
Thank you, John, and good morning. I'll begin with our Q2 2026 fiscal results and the key financial drivers, then cover segment performance, our balance sheet, and updated fiscal 2026 guidance.
Today's results exclude B Medical Systems, which continue to be classified as discontinued operations unless otherwise noted. During the quarter, we recorded an additional $6 million non-cash loss related to assets held for sale.
As communicated during the quarter, the transaction has not yet closed and remains subject to financing and customary closing conditions. In the quarter, we recorded a goodwill impairment charge.
As part of our annual goodwill impairment assessment, we recorded non-cash impairment charges of $112.4 million for multiomics and $36.6 million for Sample Management Solutions, both reflected in GAAP operating expenses. This was driven by a combination of factors, including the sustained decline in our stock price, the decrease in our near-term outlook, and a more uncertain macroeconomic and geopolitical environment, which together reduced the estimated fair value of the units below its carrying value.
To supplement my remarks today, I will refer to the slide deck available on our website. Turning to slide 3.
Total reported revenue was $145 million, up 1%, including $1 million from UKBC. Excluding UKBC and the impact of foreign exchange, revenue was down 3% organically.
Second-quarter performance came in below our expectations and reflects continued divergence across our segments, with softness in multiomics driven by lower volumes in North America and a decline in Sample Management Solutions driven primarily by lower volumes in capital-intensive automated and cryogenic store systems. This was partially offset by strong growth in Sample Repository Solutions, reinforcing the strength of our recurring revenue offerings.
Non-GAAP EPS for the second quarter was a loss of $0.04. Adjusted EBITDA margin was 5.4%, down 320 basis points year over year, primarily reflecting lower volumes across the portfolio and reduced fixed cost absorption leading to gross margin pressures, as well as store quality rework costs and an increase in inventory reserves.
Free cash flow including B Medical was $5 million in the quarter, driven by improvements in working capital and higher deferred revenue. We ended the quarter with $565 million in cash, cash equivalents, and marketable securities.
This provides continued financial flexibility to invest in the business, pursue strategic opportunities, and return capital to shareholders over time. Now, let's turn to slide 4 to take a deeper look at our results in the quarter.
Total revenue was $145 million, up 1% reported and down 3% organically, with a 3% impact from foreign exchange and 1% from the UKBC acquisition. Multiomics performance reflected lower volumes driven by softer demand and increased competitive intensity in North America.
Within Sample Management Solutions, results were supported by continued strength in biorepositories, but was negatively impacted by ongoing softness in capital equipment demand, reflecting more cautious customer capital spending behavior. Turning to gross margin.
We delivered 44.3% for the quarter, down 110 basis points versus the prior year. The decline was primarily driven by lower North America volumes, which reduced fixed cost leverage, as well as a non-cash inventory charge and approximately $2 million of quality costs associated with automated stores rework, which was in line with our expectations.
While the quality issues are largely behind us, we expect to have some additional costs in the third quarter. We have put changes in place to improve quality and reliability.
We've restructured the engineering team into three teams: new product development, current projects, and sustaining, in order to drive clear accountability in the R&D organization. As we discussed at Investor Day, we are transitioning from highly customized systems to a more modular product strategy that enables configurable and quality-controlled solutions.
In parallel, we have strengthened execution leadership by hiring an experienced project manager with a background in large-scale, complex programs, bringing additional discipline, structure, and visibility to execution. Adjusted EBITDA was $7.8 million, or 5.4% of revenue, down 320 basis points year over year.
The decline was primarily driven by 120 basis points of pressure in multiomics from lower volumes and gross margin compression, as well as down 360 basis points from investments in sales, product marketing, and R&D to support future growth. These impacts were partially offset by 80 basis points benefit in Sample Management Solutions, reflecting additional pressure from stores quality rework and inventory reserve and lower volumes, offset by the favorable impact of an accounting adjustment.
Lastly, there was a benefit of 80 basis points from other income. Importantly, while we continue to take actions to optimize and right-size our cost structure, we are committed to our growth investments to support long-term growth and strengthen our competitive positioning.
Again, non-GAAP EPS was a loss of $0.04 per share. With that, let's turn to slide 5 for a review of our segment quarterly results, starting with Sample Management Solutions, or SMS.
Sample Management Solutions delivered revenue of $81 million for the quarter, up 2% on a reported basis and down 3% organically. Biorepository Solutions, which is roughly 40% of the SMS segment, delivered high single-digit growth, reflecting focused commercial execution and the benefits of the strategic emphasis placed on this business over the past year.
Consumables and instruments delivered modest year-over-year growth supported by steady demand across the installed base. The segment was impacted by external factors with lower capital spending, which impacted orders in automated and cryogenic store systems, resulting in a low double-digit decline in core products.
Gross margin for Sample Management Solutions was 47.4%, up 40 basis points versus the prior year. The result reflected headwinds from lower volumes, store quality rework, and an inventory reserve, which were more than offset by the benefit of an accounting adjustment, as well as improved biorepository margin.
Turning next to the multiomics segment. Multiomics revenue for the quarter was $64 million, flat on a reported basis and down 2% organically, reflecting a decline in global Sanger and lower volumes in North America, driven by softer demand and increased competitive intensity.
Next-generation sequencing grew mid-single digits and gene synthesis delivered mid-single-digit growth supported by continued oligo demand in China. Europe and Asia-Pacific continued to perform well, supported by strong execution and commercial initiatives.
In North America, we are focused on improving commercial execution and driving more targeted engagement across key markets as we move through the remainder of the year. Multiomics non-GAAP gross margin was 40.2%, down 300 basis points year over year.
The decline was primarily driven by lower fixed cost absorption and unfavorable regional mix, reflecting reduced volumes in North America and the resulting loss of operating leverage. This was partially offset by more stable performance in Europe and Asia, though not sufficient to fully offset the pressure from lower North America volumes.
We are taking targeted cost actions to better align our cost structure. Next, let's turn to slide 6 for a review of the balance sheet.
As I mentioned, we ended the quarter with $565 million in cash, cash equivalents, and marketable securities. We have no debt outstanding.
Capital expenditure for the quarter was approximately $7 million, reflecting continued investment in automation, capacity expansion, and technology to support scalable growth. Turning to guidance on slide 8.
We are updating our fiscal 2026 guidance to reflect first-half performance trends and what we are seeing in the market. We expect total reported revenue to be in the range of approximately $603 million to $621 million, including the contribution of UKBC.
On an organic basis, we expect revenue to range from a decline of approximately 2% to a growth of up to 1%, compared to prior guidance of 3% to 5% growth. We expect adjusted EBITDA margin to range from down approximately 125 basis points to flat year over year, compared to prior expectations of approximately 300 basis points expansion, excluding UKBC.
This is driven by continued pressure due to lower volumes and a loss of fixed cost leverage. Free cash flow is expected to improve between approximately 10% to 15% year over year, compared to prior expectations of approximately 30% improvement.
The low end of the range reflects continued softness in multiomics in North America and in the capital-intensive products within Sample Management Solutions, while the high end reflects a modest increase in demand in North America, additional order closures for stores and cryo, and incremental revenue pull-through. At the segment level, we now expect Sample Management Solutions to grow approximately low single digits organically versus prior expectation of mid-single-digit growth, and multiomics to decline in mid-single digits versus prior expectations of low single-digit growth.
Looking ahead to the second half of the year, I'll offer some directional color to help frame the cadence of performance. In the fiscal third quarter, we expect organic revenue to grow low single digits.
For the fiscal fourth quarter, we expect organic revenue to decline low single digits. If you recall, fiscal fourth quarter of 2025 was a record revenue quarter and presents a tough comparison.
From a profitability standpoint, we expect adjusted EBITDA margins to improve sequentially, with margins moving into the low double-digit range in Q3 and then stepping up more meaningfully in Q4, reflecting the combined impact of volume recovery, cost actions, and second-half seasonality. In closing, while we are updating our full-year fiscal outlook to reflect the current demand environment, we remain focused on disciplined execution and operational control across the business.
We're taking the necessary actions to align our cost structure and to improve the performance across both segments. Importantly, we remain confident in the long-term fundamentals of our markets and in our ability to achieve improved performance over time, supported by the progress we continue to make across the organization.
As John mentioned, given the guidance reset this year, we have decided to push out the long-range plan we outlined at our Investor Day in December 2025 by one year, from 2028 to 2029. The same financial targets remain, and we believe that the market opportunity, strategic priorities, and value creation frameworks are strong.
This concludes my prepared remarks. I'll pass the call to John for a few closing remarks.
John Marotta
To close, we are encouraged by the continued strength and resilience of the recurring revenue base of our portfolio. We are taking decisive actions to strengthen commercial and operational execution and drive more consistent and improved performance.
We are also pleased with the progress of the UK Biocentre acquisition and look forward to the opportunities ahead of this strategic action. Finally, we remain disciplined in our capital allocation, continuing to invest to drive organic growth through R&D and go-to-market capabilities, pursuing disciplined and strategic M&A, and returning capital to shareholders when appropriate.
With that, operator, we're ready to open the line for questions.
Operator
Thank you. In a moment, we will open the call to questions.
The company requests that all callers limit each turn to two questions from each analyst: one question and one follow-up. If you would like to ask a question, please press *1 on your telephone keypad.
A confirmation tone will indicate your line is in the question queue. You may press *2 if you would like to remove your question from the queue.
For participants using speaker equipment, it may be necessary to pick up your handset before pressing the star keys. One moment, please, while we poll for questions.
The first question comes from David Saxon with Needham. Please go ahead.
David Saxon
Great. Good morning, John and Lawrence.
Thanks for taking my questions. Maybe I'll just ask one on fiscal second quarter.
Would love to understand kind of the cadence you saw throughout the quarter. How did things start off?
How did they progress? Were there any meaningful orders or customers that got slipped or pushed out?
Just trying to understand the exit velocity as we go into the fiscal second
Lawrence Lin
half. Hi, David.
Good to hear from you. Maybe why don't we kind of start with what we saw in Q1 really quickly and then walk to Q2, right?
In multiomics, what we saw in Q1 was bookings were slow in North America. As a reminder, multiomics North America is roughly 50% of the revenue for the segment.
This was attributable to the October shutdown and the NIH funding delay. We had key sales leaders and sales reps that were no longer in the company that created a bit of a commercial gap.
Now, Europe and APAC performed well, and we thought these were transitory events. Now, let's step into Q2 for multiomics.
We expected several dynamics to improve as the quarter progressed. In North America, the first two months, we saw improved bookings demand.
Our month-three spike seasonality just did not materialize. Usually, we see a pretty big hockey stick in terms of demand.
On a commercial execution perspective, we saw rep productivity, but we still saw gaps. As we brought in several new reps, but there were still commercial execution challenges.
When you look at the competitive dynamic particularly in North America, and it really did intensify in the quarter, particularly in gene synthesis. Now, on the bright side, as I mentioned earlier, Europe and APAC continue to perform, and this is really isolated to a North America issue in multiomics, okay?
Now, let me pivot to SMS. What did we see in Q1?
We saw slow bookings in stores and cryo. A lot of these capital-intensive products, we were seeing pushouts.
Positive note, biorepositories were high single-digit growth, C&I was low single-digit growth in the quarter. When we move into the second quarter, while we had really good visibility in our capital equipment pipeline by opportunity, we did not see these order conversions in the quarter.
Let me give you a couple examples. One, we had a multi-million-dollar cryo deal with a biotech firm that got pushed out.
Secondly, we had a multi-million-dollar automated government store that got pushed out. We haven't lost these orders, but they're just now delayed.
Timing issue such as these are a funding delay or site readiness has really caused us to get these items pushed out through the balance of the year. Again, positively in the quarter, biorepositories were high single-digit growth, C&I was low single-digit growth.
We just really had some challenges around our capital-intensive products. As I mentioned earlier, these lower volumes I just described really create this lost leverage with our existing cost infrastructure.
Hopefully, that provides the color you were looking for, David.
David Saxon
That was helpful. Thanks for that.
Then, I guess just in terms of some of the initiatives you've already put in place, like pricing in SRS, I think you have some pricing coming through in C&I. After that backlog is kind of worked through, you have moving to a more modular systems on the store side.
I guess the question is, when do we start to see the benefit of that? As you think about the cadence over the fiscal '29 LRP now, zooming out, how should we think about the trajectory over that period?
Thanks so much.
John Marotta
David, thank you for the question. Let me start with the '29 LRP and kind of get us back anchored into our IR day.
If you look at [coughs] the total SAM, talking about a $6 billion SAM. Let's go kind of strategic vector by strategic vector and get us kind of anchored back into that.
In our biorepository business, it's a nearly about a billion-dollar business at mid to high single digit. We're well positioned there because there's a number of growth drivers there.
Ultra-cold, you've got good research volumes coming out in terms of the sheer volume of samples. There's a lot of emphasis around productivity, more therapeutics coming out, and those sorts of things.
That's a key market driver, and we're well positioned there. We're going to continue to invest behind that.
That gives us some confidence around our LRP, certainly. Second is around gene synthesis.
That's north of a billion dollars, that market's growing double digit in certain areas. This is an area that we are investing behind clearly with bringing Trey in.
We certainly have to do a little more work on the cost side to get this business better positioned. Now, what's driving that?
Double-digit growth, cell and gene therapy, a lot more research and therapeutics are driving the gene synthesis market, and we're investing behind that. Thirdly, is our automated solutions.
That's north of a billion, growing at mid to high single digits. We are investing clearly around small stores and modules.
What's the growth driver in market as well? Everything is moving to ultra-cold and cold.
We're well positioned there. The number of assets that are in the field right now going from thousands to millions, people want to automate that.
The stores, automated stores and automated cryo units are kind of the epicenter of all of that. There is a clear push for productivity and a clear push around cell and gene therapy and the investments behind that.
That gives us the confidence around our LRP because we're holding our growth investments in there specifically. We could dramatically improve our margins today if we came off of some of those growth investments.
I realize also we've got some room to improve forecasting, both internally and externally here. I've got some confidence around this specifically around our LRP.
Hopefully, you're going to see some more detail coming out around how we're looking at things externally in terms of the earnings supplement that was put out. That's going to continue here.
Then internally, we've got our GMs in place, and certainly we've got our finance leads in place in each of the businesses as well. There's people waking up every day to [coughs] drive performance in these businesses, in these strategic areas, and they've got the finance leads that are in place as well.
David Saxon
Great. Thanks for that.
That earnings supplement is super helpful, looking forward to that going forward.
John Marotta
You bet. Thank you for the feedback.
Operator
Thank you. The next question comes from Matt Stanton with Jefferies.
Please go ahead.
Matt Stanton
Thanks. Maybe two-parter on the reset.
Multiomics going from low singles to down mid-singles. Maybe just talk a little bit more about what you saw.
I think you talked about competitive pressure. I think you guys have been hiring 20, 25 people on the commercial side.
Are you saying those are no longer a tailwind for the back half of the year? I guess what changed to help us bridge the guide down on multiomics here?
Then maybe, John, just stepping back on the LRP reset. If you're going to touch that less than six months later from the Investor Day, why not maybe revisit the numbers to de-risk those if you're going to push it out a year?
Was there any consideration to move any of the numbers either on the margin or the growth side to help de-risk that bridge from, call it, flat growth this year to high singles now in '29? Thanks.
John Marotta
You bet, Matt, and thanks for the question. Both Lawrence and I will give you some color here.
Let's talk about multiomics. We had clearly kind of a [clears throat] human capital reboot in North America right now.
North America sales, we had some folks that left, and then BD, we've added headcount in all of the regions right now. Where you can see there are bright spots right now from a growth perspective and double-digit growth is clearly in Europe and China right now.
Those teams are performing well. Where we're kind of going back at things in North America is, in fact, we think there's still a tailwind there in NGS.
We've got to do a little more work around gene synthesis in North America. There's some competitive dynamics that are going on there that Trey's going to be coming in and we're going to be solving for.
Then lastly, in North America business, we've talked about this, is from a structural point of view, we've got 14 labs, we're going to be rethinking that business, I can tell you, specifically around Sanger and how we drive performance going forward. I'll touch on the LRP, then I'm going to hand it over to Lawrence here.
Regarding the LRP, we did clearly think about what the revenue profile looks like over time. We really went into the plan detail by detail, looking at the waterfall of the plans, the phasing by years.
We've kept nearly $20 million of growth investments in the business right now. Matt, that's where we're coming down.
It was one of the reasons I wanted to share kind of how we view the market in biorepository, gene synthesis, and automated solutions. Those are mid to double-digit growers across all three of those right now.
We're holding our growth investments, and we've got conviction around that plan over the three years that we outlined. More importantly, seeing those growth investments through gives us the confidence around this phase shift in the program right now.
The opportunity is clearly still in front of us, and we've got to go get that. I think it's one of the things that I continue when I say we're guiding us annually, that's what I mean by that is this opportunity is still in front of us, and we're investing behind that with the numbers that I just shared with you.
Lawrence, you want to talk about some of the numbers around multiomics?
Lawrence Lin
In terms of guidance, and hi, Matt, when you look at the overall guide, right, as I mentioned earlier, the low end of the range of down 2% on revenue really just going to reflect the greater softness in multiomics in North America. Then really when you look at the plus 1% is we reflect a slight pick-up in overall multiomics North America bookings.
Again, Europe and APAC continues to be strong for us in the multiomics business. Certainly, to John's point, there's a bit of a reset around the commercial engine in North America.
We've accounted for that in our low-end guide to de-risk it.
Matt Stanton
Great. Thanks.
Then maybe just a little bit of cleanup. B Medical, appreciate the update.
How do we think about the scenarios from here? The timeline was the end of March.
Sounds like you guys are continuing to work through it. Do we expect the resolution sooner rather than later?
Then, Lawrence, just help us, how long can you keep this in discontinued ops in a scenario where it needs to come back into continuing ops? Any chance you can kind of remind us of what the margin profile of that asset is today?
Thank you.
John Marotta
Sure. I'll take the first part of the question, and Lawrence can take the second.
Right now, where we sit, we feel pretty good about where we are. We're getting weekly updates from the team right now.
Yes, there was a financing delay, certainly outside of our control. A lot of things going on in that part of the world right now, specifically in some of the end markets that they serve.
I think the team is back on track. We've had direct conversations with the banks, and we've got more conviction on that close right now.
Lawrence Lin
Matt, in terms of if there is a need to reconsolidate, that would happen at the next quarter point, June 30th.
Matt Stanton
Okay. Anything you can say on just margins if that does happen in that scenario?
Lawrence Lin
We'll evaluate that at the time, and we'll provide an update if that happens. Like John says, we feel confident that this will close.
Matt Stanton
Thank you.
Operator
Thank you. The next question comes from Mac Etoch?]
with Stephens. Please go ahead.
Mac Etoch
Hey, good morning, and thank you for taking my questions. Maybe just to start following up on some of the multiomics conversation that you've already had.
Margins have been under pressure, growth expectations are coming down for this fiscal year, but can you just unpack how much of the margin pressure is really driven by those temporary factors like utilization versus the more structural dynamics and how that informs your confidence in the recovery and in the LRP as well?
Lawrence Lin
Mac, thanks for the question. As we look at the overall guide for the year around leverage, for the year, it's about $14 million in terms of lost leverage.
80% of that is related to multiomics. Now, what I will say is we've taken actions in the second quarter, and we've done partial restructuring that will yield $7 million of annualized savings and $3 million in-year.
As John mentioned earlier, we're also evaluating currently the rooftops and labs. Let me give you a little bit more color.
When we look at the overall fixed costs in the business, there's just too much costs. There is 14 labs that were built to support a much larger Sanger footprint than the demand environment supports today.
With the sustained lower volumes, this has really created pressure on profitability.
Mac Etoch
Appreciate that. I guess just to follow up on that.
How are these efforts kind of factored into your updated LRP? I know just pushing it out by a year, and there's not really any update between the different segments.
Anything in terms of a gating factor between the year or FY '26, '27, '28 might be helpful for our context.
Lawrence Lin
I think it's a great question. Certainly when we look at the overall confidence in LRP, right, that's why we're kind of holding to those targets.
John Marotta
Mac, it's all contemplated in the phase shift of the LRP.
Lawrence Lin
That's right.
Mac Etoch
I appreciate you taking my questions. Thank you, all.
John Marotta
Sure. Bet.
Thank you.
Operator
Thank you. The next question comes from Vijay Kumar with Evercore.
Please go ahead.
Vijay Kumar
Hi, guys. Thank you for taking my question.
I guess, my first one is, a big picture. When you look at rest of life science tools, space, we've generally seen stable end markets, stable capital environment.
When you talk about end markets, when you talk about capital constraints, bookings in North America for gene synthesis rates, there seems to be a disconnect between what we're hearing from peers versus trends Azenta is seeing. How much of this is Azenta company-specific versus market issues in your mind?
When you think about back half, what is the guide assuming? Are you assuming current market environment that Azenta is facing sustains in the back half, or are you assuming further deterioration in your end markets?
John Marotta
Sure. It's a fair question, Vijay, and thank you for that.
Let's unpack it first from an end-market perspective. If you look at our North America GENEWIZ business, really the headwinds we've seen is we had a commercial reboot.
That's on us in terms of the human capital side. That's first thing there.
Second thing is, we did make some commercial investments, and we've got some execution shortfalls in that. Again, that's on us.
Around the end market and what we're seeing in our pharma, biotech, and academic customers, a lot of the performance issues we're seeing is really based on what's called this PCNS business. Think about that as specialty CRO.
It's large project-related revenue. Very similar to our POC business in stores and our capital equipment business in cryo.
There is a funnel, a weaker funnel than we had because of some of the human capital turnover that I've talked about. The biggest driver in North America is, of course, related to Azenta-specific, and that is our Sanger business.
That is declining 17%. It's been a big issue for us internally.
We are going to be solving for that. On balance, I would say of the number of items I've talked about, I would say on balance about 60% to 70% are Azenta-specific, Vijay, and we're going to be solving for those.
We've got plans in place. One of the things we've got with Trey coming in, we're very excited about his grip on the business just four weeks into the business here today.
That's the way I would think about GENEWIZ specifically in North America. If we unpack stores and cryo business, these are big-ticket items.
Right now we're seeing pharma and biotech kind of investing in small pockets here and there, but remember, these are big-ticket CapEx. When we review the funnel, we're looking at that, and we've got a good grip on that funnel, we've got a good grip in terms of the competitive dynamics.
We're not seeing a share loss here. This is just a pushout.
Our interpretation of that is is pharma going to continue to invest? Where are they going in bioprocessing?
They're clearly doing that. Would this reshoring thing, are they going to move more dollars over there or are they going to put that into R&D and some of these large stores?
It's a bit of a mixed bag right now, and I think that is really around end markets. I don't view our performance in stores as an Azenta-specific issue at this point in time, if we're just calling it down the middle as we see it, Vijay.
Cryo, we had some new salespeople, we had a commercial reboot in North America. I think we were clear when Joe came in, he's got to rebuild our North America sales organization, he's done that.
On balance, Vijay, I would call it on cryo a bit of a 60/40, 60 being in end market, meaning a lot of the funnel, and we go project by project on these large CapEx deals. A lot of that's been pushed out.
40%, I would say, is this commercial reboot when Joe was coming in and rebuilding our North America business. On balance, that's how I would look at unpacking the big issues in the business.
Specifically, what is Azenta-related and what is end-market-related. Do you want to talk about the forecast, Lawrence?
Lawrence Lin
Look, hi, Vijay. When we contemplated the overall guide, the low end of the revenue range, we believe the plan's largely de-risked, right?
Importantly, we've really taken a conservative posture to the outlook and paired it with cost actions and operational discipline that John talked about. That's why we believe that the revised guidance is appropriately balanced with realism and execution focus.
Vijay Kumar
Understood. Maybe, John, on some of those comments you made on human capital, sales force issues, what is the plan for fixing these issues, right?
Do you have the personnel in place, or do we need to hire people? How do you track productivity?
Is that a 6-month from now where we should see a turn in some of these businesses?
John Marotta
Yeah. On the human capital side, we have a North America leader in GENEWIZ.
With Trey coming on board, he's going to be bringing a leader from North America in multiomics. We're excited to bring about new talent into the business.
With Trey being here and his grip on the gene synthesis business, he spent many, many years there, and so we're excited about bringing in the right talent to go drive performance there. That was a gap for us for basically Q1 and Q2.
That's on us. We've got really good sales reps in place right now, and we've got really good regional managers in place right now, and so we're driving performance there.
We track productivity clearly. Ramp time is 6 to 9 months in that business right now.
I think there's some room for improvement around specifically around NGS. I think we're more confident in that area.
We're building more capabilities in our gene synthesis business, and we've got to go solve for cautious issues in Sanger. We've got the right people now with Trey in place to go do that.
I hope that helps, Vijay.
Vijay Kumar
Helpful. Thank you.
John Marotta
Sure.
Operator
Thank you. The next question comes from Paul Knight with KeyBanc.
Please go ahead.
Paul Knight
Hi, John. You were talking about the reorg of the automated stores group into three groups.
Did I read it correctly that the automated stores technology is kind of a new footprint, a more reliable footprint? It seems it will always had some issues before you even.
Is that what I understood there, is this a new kind of way of producing and selling and servicing the stores product? Yeah.
John Marotta
Let me pull us back and discuss kind of how we're thinking about stores in general. Let me just touch on the quality side of it first and how that's informing us in terms of what you're talking about in terms of restructuring, how we restructured that business in general.
When we came into the business, we had 18 stores quality issues. 18 of those stores did not work in the field.
We're down to three right now. Two customers, three stores.
Nothing's changed in terms of the quality issues that we've got to remediate and more importantly the timeframe to go do that. We're going to be lapping that this next quarter here.
In terms of trend and how we're more attacking the general dynamics around quality in the bespoke nature of our current portfolio there. When we came into the business, there was over a hundred and some quality tickets.
I'm very pleased the fact that the team, and these are minor issues, but the team's down to around a handful, meaning 20-some. Part of the bespoke nature of this is you've got some service gaps that were occurring in the business.
I'm very pleased with the team in terms of how we've addressed these. More importantly, our customers are thrilled about that.
It's been a good investment for the company. What are we going to do about it going forward here?
Customers clearly want these products. We don't see share loss with any of these quality issues at all, bluntly.
Secondly, it's what do we want to go do going forward? When you're in a mid to high single-digit business, there's a gap in our portfolio.
What's the gap? Small, modulated stores, one.
Two, these larger stores that are highly configurable, meaning you've got standard modules that are off the shelf right now. That goes to the point around restructuring our R&D group, which was to your question, Paul.
That is that R&D group now is waking up every day. One part of that group wakes up on new product innovation.
The second part of that group wakes up every day and they work on the POC part of that business. Then the third one is sustaining engineering, and they're working around existing quality issues in the field, what we call PPV, price performance variance, which is around procurement, and then value add, value engineering.
That's what they're waking up every day and doing. Now, let's talk about the timing of this, okay?
The timing of implementing all of this was Q1. We put our general managers into the business in Q1 in automated stores and cryo, that's Jeff.
We put Michael in C&I in that business to drive performance there. Then Alex in the biorepository business.
All of those general managers came in in that November-December timeframe. They're getting more clarity around the business clearly.
Then our finance leads are coming in there, too. We think we're going to have more of a grip on the business just from a execution of the roadmap, but more importantly, how we're driving forecasting into the business.
I know we've got a little work to do internally forecasting, and more importantly externally forecasting here. All of that to say, structurally, Paul, I think we're in a much better place and how we're driving that going forward in automated stores.
Thanks for the question.
Paul Knight
Sure. Then the last on multiomics.
Is Sanger obviously you want to change the roof, the number of roofs. Is Sanger moving into other next-gen techniques that are longer read length?
Does it imply less Sanger in the future, more next-gen in the future?
John Marotta
Sure. What is going on in Sanger business is you've got technology disintermediation, okay?
Is Sanger ever going to go away? No.
There's a shift, a clear shift to the ONT, Oxford Nanopore technology, which we also offer, okay? We've got thousands of drop boxes globally.
We've got a big commercial footprint here. Bluntly, we were on our heels in terms of bringing the new technology into GENEWIZ.
We're now on our front feet in doing that. I think with Trey coming on board, we're going to get more aggressive in this technology conversion.
That lends us to the fact that we've got to then right-size the Sanger business, but also meeting our customer needs with the right balance of Sanger. If you look at a multiomics business competitively differentiate having gene synthesis on the writing side of genes and then next-gen sequencing including Sanger and Oxford Nanopore, it's strategic.
We need the right balance of having NGS, Sanger, and ONT in the business to drive a synthesis strategy here. Trey is the one that is really well positioned to do that.
All of that right now, Paul, we're on our front feet to go do.
Paul Knight
Thanks.
John Marotta
Sure.
Operator
Thank you. The next question comes from Brendan Smith with TD Cowen.
Please go ahead.
Brendan Smith
All right. Thanks for taking the questions, guys.
Appreciate all the color here on North America versus other regions. Maybe just following up kind of on that last question.
I guess even really from a priorities basis, you mentioned some of the GENEWIZ dynamic in North America, but I know we've even seen, for example, some AI-driven demand for some of these tools from biotech and pharma starting to crop up here. I guess I'm really just wondering how you kind of see Azenta's competitive opportunity in sequencing versus synthesis, and maybe if one ultimately makes more sense to kind of really lean into first, just kind of order of operations from here over the next few months.
Thanks.
John Marotta
Sure. If you look at what we talked about in IR Day in terms of you've got gene synthesis, north of a billion dollar end market, growing double digit, very high margins.
We have that in our hands today, and we're executing well specifically in that in Europe and in China. Where we think that there is room to improve in our strategy is up-indexing us from a technology perspective, specifically in North America, and kind of what we outlined in our strategy is this decentralized up-indexing from a technology perspective.
We think there's a lot of room there. The evidence of that, Brendan, is clearly in bringing Trey in.
In order to execute our strategy, you've got to have the right person to do it. He's a clear expert here.
For our strategy, we need to have both in terms of reading and writing of genes. Going to your question around AI, this is an area that I think you're going to hear more from us in as this strategy starts to evolve around gene synthesis, up-indexing us from a technology and a double-digit growth perspective and getting us more on our front foot there.
We're pretty excited about that. We do have bioinformatics internally.
We are investing in that specifically. That's in our hands today.
I think you're going to see some more partnerships and some more things around our inorganic activities around that specifically. I hope that helps, Brendan.
Brendan Smith
Yep, got it. Makes sense.
Thanks, guys.
John Marotta
Sure.
Operator
Thank you. We have reached the end of the question-and-answer session.
I will now turn the call over to John Marotta for closing remarks. Please go ahead.
John Marotta
Very good. Thank you, operator.
To close, I want to recap on a few things. First, I want to emphasize our confidence in the strategic priorities as outlined in our Investor Day: scaling our biorepositories, advancing our gene synthesis technology, and our new product innovation in automated solutions.
We're really focused on getting the portfolio centered around those three areas and increasing our recurring revenue focus. As I've stated, we're not satisfied with our results, and we have some work to do to transform multiomics and stabilize our performance.
I'm confident on our team's ability to do so, and the new leadership we've brought in to help us do that. Want to thank our employees and our shareholders for their support and our commitment to Azenta.
Thank you very much.
Operator
Thank you. This concludes today's conference call.
You may now disconnect your lines. Thank you for your participation.