- Business
- GeoVax Labs, Inc. (Nasdaq: GOVX; GOVXW) is a clinical-stage biotechnology company developing novel vaccines and immunotherapies against infectious diseases and solid tumor cancers using proprietary modified vaccinia Ankara virus-like particle and gene-directed enzyme prodrug therapy platforms; its lead infectious disease candidate is GEO-CM04S1, a next-generation COVID-19 vaccine in three Phase 2 clinical trials evaluating it as a primary vaccine for immunocompromised patients including those with hematologic cancers and chronic lymphocytic leukemia, and as a durable booster for healthy adults previously vaccinated with mRNA products; additional preventive vaccines target Mpox and smallpox with planned Phase 3 evaluation per recent EMA guidance, hemorrhagic fever viruses including Ebola Zaire, Ebola Sudan, Marburg and Lassa, malaria, Zika virus and human immunodeficiency virus; in oncology, lead product Gedeptin, an oncolytic gene therapy with Orphan Drug Designation for oral and pharyngeal cancers, has completed a multicenter Phase 1/2 trial for advanced head and neck cancers and preclinical expansion to additional solid tumors such as triple negative breast cancer and cutaneous malignancies in combination with checkpoint inhibitors like pembrolizumab. The company, founded in 1988 and headquartered in Smyrna, Georgia, maintains U.S.-focused operations with worldwide intellectual property rights, collaborations including the National Institutes of Health and U.S. Department of Defense, and recent BARDA-supported revenue growth to $2.5 million in Q2 2025; latest developments encompass a September 2025 $2.5 million registered direct offering for clinical advancement, September 2025 preclinical expansion of Gedeptin development leveraging KEYNOTE-689 checkpoint data with Phase 2 initiation for head and neck cancer planned for H2 2026, and ongoing enrollment in GEO-CM04S1 Phase 2 trials with new sites added.