Good morning and good afternoon, everyone. Thank you for joining us for Innate Pharma's first half 2026 business update and financial results conference call.

The press release and today's presentation are both available on the IR section of our website. Before we begin, I would like to remind everyone that today's presentation includes forward-looking statements based on current expectations.

These statements involve risks and uncertainties that could cause actual results to differ materially. To briefly cover today's agenda, our CEO, Jonathan Dickinson, will begin with a strategic overview and outlook.

Markus Jensen, our Chief Medical Officer, and Yannis Morel, our Chief Operating Officer, will then take us through updates on lacutamab, IPH4502, monalizumab, and our preclinical ADC pipeline. Frédéric Lombard, our Chief Financial Officer, will then review our financial results.

Jonathan will return for our upcoming catalysts and closing remarks before we open the call for Q&A. With that, I will now hand it over to Jonathan.

Thank you, Stephanie. Good morning to those joining from the US and good afternoon to our European participants.

Turning to slide five, the first half of 2026, together with developments since the end of the period, has been marked by important progress across our focus portfolio. Starting with lacutamab, in August we announced our strategic partnership with Sobi to advance the program in T-cell lymphoma.

As announced yesterday, that partnership is now effective following the closing of the deal. The TELLOMAK-3 Phase 3 has been initiated.

We are targeting the first patient in the study in Q1 2027 as we work toward a filing for accelerated approval in Sézary syndrome in H2 2027. For IPH4502, as announced in July, we completed Phase 1 dose escalation and cohort enrichment enrollment, and have seen preliminary antitumor activity, including objective responses in post-EV urothelial cancer, as well as in non-small cell lung cancer and head and neck cancer, with a favorable safety profile observed to date.

We will share initial Phase 1 dose escalation data at the EORTC-NCI-AACR meeting on November 18th, 2026, in Barcelona. Turning to monalizumab, enrollment in the PACIFIC-9 Phase 3 study has been completed, and we continue to expect the Phase 3 readout in the second half of 2026.

Financially, our position has been strengthened by the $75 million Sobi upfront payment associated with the closing of the deal, and the €30 million equity financing. Together, these are expected to extend our projected cash runway through the end of the first quarter of 2028.

Taken together, we believe these developments position Innate for several important catalysts in the second half of 2026. Let me start with lacutamab.

Lacutamab is our anti-KIR3DL2 antibody being developed in cutaneous T-cell lymphoma, or CTCL. Turning to slide seven, as I mentioned, in August we announced a strategic partnership with Sobi to license lacutamab in T-cell lymphoma.

The transaction has now closed. TELLOMAK-3, our confirmatory Phase 3 study in CTCL, has been initiated, with the first patient expected in the first quarter of 2027.

Innate will conduct the Phase 3 study, and we will file for accelerated approval in Sézary syndrome based on the existing Phase 2 TELLOMAK data. Upon the potential accelerated approval, Sobi will receive exclusive global rights to commercialize lacutamab.

Following positive Phase 3 results, Sobi will be eligible to obtain full global development rights. Under the terms of the agreement, the transaction includes a $75 million upfront payment, up to $40 million in near-term milestones connected to Sézary syndrome, and up to an additional $465 million related to Sobi's option to obtain full development rights and future regulatory and commercial milestones.

The agreement also includes tiered double-digit royalties on future net sales. I'll now hand it over to Markus to review the regulatory and development path forward.

Markus?

Thank you, Jonathan. Lacutamab is now progressing towards Phase 3 TELLOMAK initiation and planned accelerated approval filing.

From a regulatory and development perspective, the path forward is well defined. We have FDA clearance to proceed with TELLOMAK-3, which now has been initiated with the first patient expected in the first quarter 20— 2027.

The study includes a confirmatory cohort in Sézary syndrome and a registrational cohort in mycosis fungoides. The existing Phase 2 TELLOMAK data are intended to support an accelerated approval filing in Sézary syndrome once TELLOMAK-3 is underway, with a filing currently planned for the second half of 2027.

As a reminder, lacutamab has received Breakthrough Therapy Designation from the FDA for relapsed or refractory Sézary syndrome, as well as Fast Track Designation from the FDA, PRIME designation from the EMA, and orphan drug status in both the United States and Europe. With the regulatory pathway established and the Sobi partnership now effective, our focus is on advancing TELLOMAK-3 towards first patient enrollment first quarter 2027.

Turning slide please, I now move to IPH4502, our differentiated Nectin-4 exatecan ADC, which is in Phase 1 clinical development for advanced solid tumors. IPH45 was designed to address some of the key limitations of the first generation of Nectin-4 ADCs.

The molecule combines an exatecan topoisomerase 1 payload with our proprietary stable linker and a high-affinity Nectin-4 antibody that binds non-overlapping epitope compared with enfortumab vedotin. We believe these features provide an important point of differentiation as the Nectin-4 ADC landscape continues to evolve.

Importantly, we are now beginning to see that profile translate clinically and have observed preliminary antitumor activity with objective responses in heavily pretreated patients, including patients with urothelial cancer following prior enfortumab vedotin treatment, as well as in non-small cell lung cancer, head and neck cancer. The safety profile observed to date has been favorable with limited hematological toxicity.

We completed dose escalation in July and are broadly tracking in line with our expectations across expansion cohorts with approximately 15 patients enrolled in both post-EV urothelial cancer, head and neck cancer, and somewhat lower enrollment in non-small cell lung cancer cohort. Data cleaning is ongoing, and we look forward to presenting the initial Phase 1 dose escalation data set at the EORTC-NCI-AACR symposium on November 18th, 2026.

Next slide, please. Our area of particular interest for IPH45 is urothelial cancer following prior EV treatment.

While EV plus pembrolizumab has significantly changed the treatment landscape, most patients progress within two years, and there remains no established second-line standard treatment after progression of that regimen. Against that backdrop, the preliminary activity we have observed with IPH4502 in heavily pretreated post-EV patients, including objective responses, is encouraging.

These remain early Phase 1 observations, and the upcoming data set will help us determine how to best advance the program. Slide 11 please— slide 12, please.

I now move forward to monalizumab, which is our NKG2A antibody being co-developed with AstraZeneca in non-small cell lung cancer. PACIFIC-9 is a randomized Phase 3 trial with unresectable Stage III non-small cell lung cancer patients who have not progressed following a definitive platinum-based concurrent chemoradiotherapy.

Study enrolled 1,051 patients and compares durvalumab plus oleclumab, durvalumab plus monalizumab, and durvalumab plus placebo as a control with progression-free survival as the primary endpoint. The program is supported by three earlier Phase 2 studies in non-small cell lung cancer, including COAST, NeoCOAST, and NeoCOAST-2.

With enrollment complete, Phase 3 data remain expected in the second half of 2026. I now hand over to Yannis to briefly review the economics of our partnership with AstraZeneca.

Thank you, Markus. As a reminder, under our monalizumab partnership with AstraZeneca, we have received up to date $450 million.

The additional potential milestone in the agreement are up to $825 million, together with double-digit royalties outside Europe and 50% profit sharing in Europe. Turning to slide 15, I'll move now to our next-generation ADC pipeline.

Beyond IPH4502, we are using our internal capabilities and technology to build a broad portfolio of differentiated ADC candidates. Turning to slide 16, leveraging our antibody discovery and engineering expertise, we have built a comprehensive ADC platform to develop a portfolio of next-generation ADCs designed to overcome the limitation of the current ones.

Building on IPH4502 linker, which stability in patients is demonstrated by our emerging clinical data, we are developing a drug candidate portfolio around three approaches. First, dual-targeted bispecific ADCs to address tumor antigen heterogeneity and to expand addressable indication compared to single tumor antigen targeting.

Second, bispecific ADCs with enhanced internalization to unlock the activity in antigen low-expressing tumors. Finally, dual-payload ADCs using complementary mechanism of action to overcome resistance.

I'll now hand over to Frédéric for our financial results.

Thank you, Yannis. I'll now provide a brief overview of our financial position for the first half of 2026.

Turning to slide 18, so as of June 30, 2026, our cash, cash equivalent, and financial asset were amounting for €21.4 million. That balance does not include the $75 million USD Sobi upfront payment equivalent to €65 million, nor the proceeds from the €30 million equity offering.

The offering represents €30 million in gross proceeds or approximately €28 million in expected net proceeds. The primary use of proceeds is the continued clinical development of IPH4502, the advancements of our preclinical ADC portfolio, and as well as general corporate purposes.

Together with the Sobi upfront payment, these proceeds are expected to extend our cash runway through the end of the first quarter of 2028. I'll now hand over to Jonathan.

Thank you, Frédéric. Moving to slide 20, and turning to our key catalysts for the remainder of 2026.

For lacutamab, following closing of the strategic partnership with Sobi, TELLOMAK-3 has been initiated, with the first patient planned for the first quarter of 2027, followed by a planned filing for accelerated approval in the second half of 2027. For IPH4502, dose escalation enrollment is complete with preliminary antitumor activity and a favorable safety profile observed to date.

We will report initial Phase 1 dose escalation data at the EORTC-NCI-AACR meeting on November 18th, 2026. For monalizumab, PACIFIC-9 enrollment is complete with the Phase 3 readout expected in the second half of this year.

We have three important near-term catalysts across our focus portfolio. Together with a strengthened financial position that supports our continued execution of these priorities.

With that, operator, we are ready to open the call for questions.

Hey, morning, everyone. Congrats on the updates.

Just one for me. Bill on for Dana.

We've seen the prior exatecan-based ADCs show some pretty good activity in the post-Padcev setting, but it did have some pretty high heme toxicities. Can you talk about IPH45's stable linker design and sort of what gives you confidence you won't see the same sort of issues?

Thank you.

Thank you for the question. Maybe, Yannis, you can take that one.

Maybe I can start and let Markus comment. We have worked on the design of the linker, and based on what we have seen at ASCO published by others with their own linker, it seems that the stability of our linker that we have seen in preclinical models, including in non-human primates, seems to be translated into the human situation leading to a very limited release of a free payload, which is one of the reason of the systemic hematological toxicity of some ADCs.

Yeah.

What we can add is the Lilly data that have been released recently, actually state that based on their own data they have seen in the trial, the unstable linker was used as an explanation for the hematological toxicity in this data set.

Great. Thank you.

Great. Good morning and thanks for taking the question.

Pending an accelerated approval there, could you speak to the potential for frontline off-label use for lacutamab in Sézary syndrome, given that seems to be the case with mogamulizumab? I have a follow-up question.

Maybe I will take that question, Jeet. Our expectation is that lacutamab will be listed in the NCCN guidelines following the accelerated approval for both Sézary syndrome and for mycosis fungoides.

I think with that listing, it seems to leave it open for physicians to be able to use the product across the different lines of therapy. Our expectation based on the safety profile of lacutamab, which is pretty benign, we expect that you will see some off-label usage in the first-line setting.

I think there's an expectation you will see that. Also, despite the fact that the accelerated approval will be in Sézary syndrome, there will also be an expectation based on the potential listing in the NCCN guidelines for mycosis fungoides that you will also see usage in MF.

Hopefully, that answers your question.

Great. Appreciate that.

Maybe just two other quick follow-ups. Just in any initial thoughts on pricing?

Do you think you could price at a premium to mogamulizumab? Then separately on PACIFIC-9, in terms of just the update format, anticipate perhaps a press release at minimum from AstraZeneca, but will Innate have their own press release and analyst call as well?

Thank you.

Yeah. In terms of pricing, we have completed pricing research in the US, which was conducted by ZS Associates.

What we were able to establish with US payers was that we can price lacutamab between $500,000 and $625,000 per patient per annum. That would be supported by our clinical data and the NCCN listing.

There is an expectation here that you will be able to achieve premium pricing particularly in an indication like Sézary syndrome with a relatively low incidence, and then be able to carry that forward into the mycosis fungoides indication, which is a larger indication, but still an orphan disease. That's pricing.

Then with respect to PACIFIC-9, you're correct. The expectation is that there will be a press release from AstraZeneca when the results are available.

We would also look to press release that as well and potentially do some analyst calls following the availability of that primary endpoint data. Hopefully, that answers the question again.

Great. Thank you.

Yes. We have a question from Clément Scetbon from Stifel.

The first question is, as dose escalation and cohort expansion enrollment are now complete, should we expect the initial ENA dataset to be primarily a safety, pharmacology update, or mature enough to inform subsequent development decision?

Markus, maybe you can take that question. Yeah.

The question is almost the answer. This is out of 11 different indications and 76 patients.

We are expecting to see relevant and informative safety data. We are also expecting response data from patients, and this will inform our next steps.

We need to fully run the tables, and we will review and disclose that as proposed on the ENA meeting.

Thank you. There is another question from Clément.

With the strengthened balance sheet following the recent financing, how far along the development path could you advance IPH4502 on your own?

Maybe I can take that. I think you're all aware that we did a small equity raise of €30 million a couple of weeks ago.

The rationale behind that equity raise was to be able to progress seamlessly into the next steps for 4502. We're well positioned now to be able to move into the next steps, whatever that will be and the data will dictate what that is, whether it's dose optimization.

We're equipped to be able to do that. If we would need to broaden the program, if the data supports going to potentially additional tumor types, then that would require additional funding to be able to conduct multiple dose optimizations across different tumor types.

At least for the initial steps, we're funded to be able to take those steps and take the product forward seamlessly into dose optimization. Hopefully, that answers the question again.

Thank you very much, everybody, for joining us today for our update following our H1 results. We look forward to updating you as we progress through the important catalysts that we outlined today, which come across the remainder of the year.

Thank you for your time, and see you soon.