Horizon Therapeutics Public Limited Company
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- Horizon Therapeutics Public Limited Company (HZNP), a biopharmaceutical company focused on researching, developing, and commercializing medicines for rare, autoimmune, and inflammatory diseases, operates primarily in the United States with additional presence in Europe; founded in 2005 and formerly headquartered in Dublin, Ireland, with key U.S. operations in Northbrook, Illinois, it functions as a subsidiary of Amgen Inc. following its $27.8 billion acquisition completed in October 2023. The company offers Tepezza (teprotumumab) for thyroid eye disease; Krystexxa (pegloticase) for refractory chronic gout; Uplizna (inebilizumab-cdon) for neuromyelitis optica spectrum disorder; Duexis (ibuprofen/famotidine) and Vimovo (naproxen/esomeprazole magnesium) for arthritis pain and inflammation; Rayos/Lodotra (delayed-release prednisone) for rheumatoid arthritis and other inflammatory conditions; Pennsaid (topical diclofenac) for osteoarthritis pain; and rare disease therapies including Procysbi (cysteamine bitartrate), Ravicti (glycerol phenylbutyrate), and Buphenyl (sodium phenylbutyrate) for urea cycle disorders, alongside Actimmune (interferon gamma) for chronic granulomatous disease and severe malignant osteopetrosis. Recent major developments include Amgen's completion of the transformative acquisition in October 2023 after FTC regulatory clearance, enabling portfolio integration and projected cost savings exceeding $500 million within three years; post-acquisition expansions in manufacturing, such as ongoing enhancements to the Waterford, Ireland facility for rare disease biologics initiated in 2022; and strategic collaborations like the pre-acquisition partnerships with Q32 Bio for autoimmune candidate ADX-914 and Johns Hopkins University for translational research in autoimmunity, alongside Amgen's continued emphasis on international growth for Horizon's rare disease assets including Tepezza, Krystexxa, and Uplizna in 2024-2025.
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