- Business
- Orexo AB (publ) (ORX.ST) is a Swedish specialty pharmaceutical company that develops and commercializes innovative pharmaceuticals and digital therapies primarily targeting opioid use disorder, addiction-related conditions, and other unmet medical needs using proprietary drug delivery technologies such as sublingual and nasal powder platforms. The company offers Zubsolv sublingual tablets for opioid dependence treatment; Abstral sublingual tablets for breakthrough cancer pain; Edluar sublingual tablets for short-term insomnia; and digital therapies including deprexis for depression, vorvida for alcohol use disorder, and modia for opioid use disorder; it also advances a pipeline featuring OX124 (iCIPRI) and OX125 as high-dose nasal naloxone and nalmefene rescue medications for opioid overdose, OX640 as a powder-based epinephrine nasal product for anaphylaxis, OX390 as an intranasal rescue medication for adulterated opioid overdoses, and OX-MPI for endometriosis in collaboration with Gesynta Pharma. Orexo operates through segments including US Pharma for commercial sales, Digital Therapeutics, and HQ/Pipeline for research, development, and out-licensing; it serves markets in the United States, European Union, United Kingdom, and internationally with a focus on patients, healthcare providers, and partners. Founded in 1994 and headquartered in Uppsala, Sweden, the company employs approximately 110 people and reported net sales of SEK 590 million in 2024. Recent developments include a September 2025 BARDA contract award of up to USD 50.9 million (initial USD 8 million) to Orexo US for OX390 development, conversion of future OX-MPI rights to SEK 19 million in Gesynta Pharma shares, preparation for Izipry (OX124) commercial launch as a nasal overdose rescue medication, ongoing partnering discussions and market research for OX640, a collaboration with Abera Bioscience on nasal powder vaccines using AmorphOX technology, and reaffirmation of 2025 positive EBITDA guidance amid Q3 revenue challenges.