- Business
- Resverlogix Corp. is a Calgary, Alberta-based late-stage clinical biotechnology company founded in 2001 that develops epigenetic therapies to treat patients with chronic diseases by regulating disease-causing gene expression through inhibition of bromodomain and extra-terminal (BET) proteins. The company's lead product candidate is apabetalone (RVX-208), a selective BET inhibitor targeting the second bromodomain (BD2) for indications including high-risk cardiovascular disease in patients with type 2 diabetes mellitus and low high-density lipoprotein levels as evaluated in the global Phase 3 BETonMACE clinical trial, post-COVID-19 conditions, pulmonary arterial hypertension, end-stage renal disease, chronic kidney disease, neurodegenerative diseases, Fabry disease, peripheral artery disease, and other orphan indications such as facioscapulohumeral muscular dystrophy. It maintains a partnership with EVERSANA to support commercialization of apabetalone for cardiovascular disease, post-COVID-19 conditions, and pulmonary arterial hypertension in Canada and the United States; Shenzhen Hepalink Pharmaceutical Group Co., Ltd., its largest shareholder, holds a US$6.0 million secured debenture extended in May 2024 for two years to May 13, 2026, with conversion privileges eliminated and interest rate increased to 18% per annum. Recent developments include the appointment of Bradley Glass, General Counsel of Hepalink USA, Inc., to the board of directors in November 2025; shareholder approval of the board at the June 2025 annual meeting; a presentation on apabetalone's anti-inflammatory and anti-fibrotic effects in cardiac fibroblasts at the European Society of Cardiology Congress 2024; and ongoing advancements in Zenith Capital funding during 2025. Operations are primarily in Canada with a U.S. office in San Francisco, California, and the company trades on the Toronto Stock Exchange under the symbol RVX.TO.