Scancell Holdings plc
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- Scancell Holdings plc is a clinical-stage biopharmaceutical company focused on the discovery and development of novel immunotherapies and vaccines for cancer treatment. The company develops products using its four proprietary technology platforms: Moditope and ImmunoBody for vaccines, and GlyMab and AvidiMab for antibodies. Its product pipeline includes vaccine candidates Modi-1 and Modi-2, targeting citrullinated and homocitrullinated cancer antigens respectively, and ImmunoBody vaccines SCIB1 and iSCIB1+, which are in advanced clinical trials, particularly for melanoma treatment. Scancell’s antibody portfolio includes candidates such as SC134, designed as T-cell redirecting antibodies for cancers including small cell lung cancer. Founded in 1996 and headquartered in Oxford, UK, Scancell operates primarily in the UK and aims to address unmet clinical needs in oncology with off-the-shelf cancer immunotherapies that stimulate durable systemic immune responses. Recent developments include the initiation of a new arm (Cohort 4) in the ongoing Phase 2 SCOPE study, evaluating intradermal administration and accelerated dosing regimens for its iSCIB1+ vaccine in advanced unresectable melanoma patients. The company reported positive Phase 2 clinical data demonstrating a progression-free rate exceeding historical standard-of-care benchmarks. It has advanced towards registration by submitting regulatory documentation to FDA and other agencies for randomized studies planned for 2026. Scancell also secured £12.1 million in funding and forged a strategic partnership with the Cancer Vaccine Launchpad to fast-track melanoma patient access. Organizationally, it has strengthened its leadership team with key pharmaceutical industry appointments to accelerate commercial capabilities. The company continues to develop its GlyMab platform via the establishment of Glymab Therapeutics Ltd to enhance antibody product development execution and commercial potential. These initiatives position Scancell for near-term clinical milestones and potential commercialization within the oncology immunotherapy market.
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Scancell's melanoma data keeps widening the gap over standard care as phase III funding race heats up
Scancell's melanoma data keeps widening the gap over standard care as phase III funding race heats up
Scancell wins FDA fast-track status for melanoma immunotherapy
Scancell receives FDA Fast Track Designation for iSCIB1+ in advanced melanoma and provides data update from its SCOPE Phase 2 study
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Scancell CFO to step down as cancer immunotherapy developer names interim replacement
Scancell Holdings plc (SCNLF) Q2 2026 Earnings Call Transcript
Scancell confirms healthy balance sheet as iSCIB1+ moves towards Phase III trial
Scancell confirms healthy balance sheet as iSCIB1+ moves towards Phase III trial
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Scancell cleared by FDA for Phase 3 trial
Scancell cleared by FDA for Phase 3 trial