- Business
- Shanghai Model Organisms Center, Inc. (688265:SHH) engages primarily in research, development, production, sale, and technical services for genetically modified animal models utilized in life sciences research and drug discovery, particularly for cancer immunotherapy and gene function studies. The company specializes in model organisms including mice, rats, zebrafish, and nematodes, employing gene editing technologies such as CRISPR and ES cell targeting to create customized and standardized models; its core offerings encompass toolbox mice, disease models for rare, infectious, nervous system disorders, and spontaneous tumors, target humanized knock-ins covering tumor targets, immune checkpoints, complements, cytokines, metabolic pathways, and viral infection receptors, immunodeficient and reporter strains, cell models including reporter-labeled and primary cells, as well as supporting services like model breeding, colony management with cryopreservation and cryorecovery, housing, genotyping analysis, phenotypic evaluation, non-GLP toxicology, pharmacokinetics, and auxiliary apparatuses such as e-BLOT Western blot imaging systems. Founded in September 2000 and headquartered in Pudong New District, Shanghai, China, the company operates mainly in the biotechnology sector, serving universities, research institutes, hospitals, and pharmaceutical firms globally with a library exceeding 6,000 off-the-shelf mouse models and over 11,000 prototypes; it maintains 731 employees and reported trailing twelve-month revenue of CNY 400.15 million. Recent developments include a five-year global collaboration agreement with Crown Bioscience announced in May 2024, extending prior ties to supply genetically engineered mouse models, cell line development, and custom GEMM models worldwide, alongside uniform pricing and IP protections; additionally, the company secured U.S. NIH Office of Laboratory Animal Welfare approval for its animal facility in January 2021 and continues expanding preclinical immuno-oncology capabilities.