Thank you, Operator. Good morning, and thank you for joining us.

Our speakers today are Emmanuel Ligner, President and Chief Executive Officer; Brent Jones, Executive Vice President and Chief Financial Officer; and Steve Eck, Senior Vice President and Chief Accounting Officer. The press release and a presentation accompanying this call are available on our Investor Relations website at ir.avantorsciences.com.

Following our prepared remarks, we will open the call for questions. A replay of the call will be made available on our website later today.

During this call, we will make forward-looking statements within the meaning of the U.S. Federal Securities Laws, including statements regarding events or developments that we believe or anticipate may occur in the future.

These forward-looking statements are subject to a number of risks and uncertainties, including those set forth in our SEC filings. Actual results may differ materially from any forward-looking statements that we make today.

These forward-looking statements speak only as of the date that they are made. We do not assume any obligation to update these forward-looking statements as a result of new information, future events, or other developments.

This call will include a discussion of non-GAAP measures. A reconciliation of these non-GAAP measures can be found on the press release and in the supplemental disclosures package on our Investor Relations website.

With that, I will now turn the call over to Emmanuel.

Good morning, and thank you for joining us today. Let me begin with a few financial highlights for the quarter.

First quarter results exceeded our expectations due to improved execution in bioscience and medtech product segments, and we have reaffirmed our full-year guidance. VWR distribution and services generated $1.15 billion of revenue in the first quarter, down 5% organically versus the prior year.

This performance was in line with our expectations despite soft market condition in Europe and adverse winter weather in the U.S. I'm pleased to report that in the quarter, the VWR e-commerce platform showed green shoots of improved performance in traffic, conversion, and revenue growth following multiple upgrades as part of our digital roadmap, as well as the successful relaunch of vwr.com.

Importantly, Q1 results provide evidence that the VWR segment is stabilizing, with financial performance in line with our expectations. Turning to BMP, BMP revenue was $431 million in the first quarter, down 2% organically versus the previous year.

This was ahead of our expectations due to better than expected execution from process chemicals and NuSil. Brent will discuss the detail in his remarks, but tough comp had a heavy influence on the year-over-year gross metrics.

I'm pleased to report that revival efforts are already taking hold in BMP. In Q1, we saw modest improvement in BMP operational performance, and we also saw strong commercial performance given the enhanced focus with which our team are working.

BMP had a book-to-bill of more than 1.1x in the quarter. Other elements of the P&L, including margins, were generally in line with expectations, and we generated 17 cents of adjusted EPS in the quarter, ahead of our expectation.

There are three key messages I want to convey about the first quarter. First, revival is already having a positive impact on Avantor.

Across the organization, we see a clear improvement in execution and increased accountability. Our team has a more intense focus on serving customers, and we are taking a data-driven approach to measure their performance.

Second, improved execution has translated into improved and more stable operational performance, most notably within the VWR platform and BMP manufacturing. Improved execution is also reflected in the strength of our order book and demand funnel.

Third, we believe that we are turning a corner financially. We believe that VWR's growth rate reached a bottom in Q1, and that BMP's growth rate will reach a bottom in Q2, which position Avantor for organic revenue growth in the second half of this year.

We moved the company forward in the first quarter, and I'm encouraged by the momentum and positive energy across the organization. In the interest of continued transparency, I want to share two example of action that we have taken as part of revival.

Please turn to slide number 4. Revival begins and ends with people, and for revival to be successful, we must have the right talent in place.

One of the first things we have done is move with speed to recruit exceptional leaders and enhance our leadership structure. This slide summarize the change we have made to the senior leadership team, defined as my direct reports plus their direct reports.

We have moved quickly to refresh approximately 25% of this leadership group, filling positions such as Chief Operating Officer, Chief Procurement Officer, head of VWR sourcing, and head of VWR pricing. Recently, we welcomed Jens Fien, our Chief Digital Officer, who joined us from Medline.

Last week, we announced that Ludovic Brellier will join us from Cytiva to lead BMP and serve as our Chief Transformation Officer. We expect to announce the addition of other high-impact leaders soon.

Many of those talent investment are self-funded with increased productivity. Year-to-date, our overall headcount is down approximately 2%.

I had a very clear vision on how the leadership team should be constructed, and in short order, we have supplemented internal talent with external talent. We have a diverse set of leaders in place whose skills and experience will allow us to best execute the revival agenda.

Please turn to slide 5. Enhancing operation is one of our foremost priorities, I wanted to dig deeper into action underway within this important revival pillar, which is led by our COO, Mary Blenn.

In the first quarter alone, we completed over eight weeks of kaizen events across our operational network. I participated in several of those kaizen event, as did other senior executives.

In parallel, we establish a capex council that meets monthly to plan, review, sanction, and monitor our capital commitments, with one eye focused on near-term needs and the other eye focused on long-term strategic requirement. Our capex council has sanctioned 12 projects recently, one of which is depicted in this slide.

This project focuses on a downstream production process at an important North American manufacturing facility, where the current workflow is a people-intensive process with scope for improvement. We reimagined the process during a kaizen, and as a consequence, are moving forward with a project to install modular automation equipment in a previously unused space in the facility.

The before and after images on the slide demonstrate how this automation project will radically simplify workflows. Furthermore, this investment will enhance quality, compliance, and throughput.

It will reduce our cost per unit, and it will free up capacity for the team to focus on a higher value activities. We expect to earn highly attractive returns on the capital we deploy.

This is just one example of the approach we are taking globally. In all our projects, including the $20 million of incremental investment we announced previously, we use tools such as Lean and kaizen to rethink the way in which we work, and we are marrying that with rigorous data-driven analysis to measure the financial consequence of our investment.

I will conclude my opening remarks with a few words about the news that Brent will depart Avantor next month. Brent, we are all deeply thankful for your leadership and contribution to Avantor, including the developments of a deep and talented finance team.

I wish you and your growing family nothing but the best in the future.

Thank you, Brent. Thank you for the kind words, Emmanuel.

It's been a privilege to serve as the CFO of this great company, and I am grateful to have worked with such a wonderful group of people. The finance function will be in good hands with Steve Eck, who is an outstanding leader, and I remain completely confident in revival and Avantor's future prospects.

With that, please turn to slide number 6, where I will review our Q1 financial results. In Q1, we generated $1.581 billion of revenue, which was down 4% on an organic basis and flat year-over-year on a reported basis.

Adjusted EBITDA in the quarter was $219 million with a margin of 13.9%. Adjusted EPS in the quarter was 17 cents due to good execution in BMP, specifically process chemicals and NuSil, allowing us to outperform our expectations.

Free cash flow in the period was $25 million. Excluding restructuring costs, free cash flow in the quarter was $39 million.

Both figures were within expectations and reflect a meaningful and anticipated headwind associated with customer pre-bates. We repaid approximately $105 million of debt and ended the quarter with an adjusted net leverage ratio of 3.3x adjusted EBITDA.

Leverage increased by 0.1 point sequentially and year-over-year, primarily due to lower trailing 12-month adjusted EBITDA. Please turn to slide 7.

Revenue for the VWR distribution and services segment was $1.15 billion in the first quarter, down 5% organically versus the prior year. The primary driver of the organic revenue performance was a decline in volumes, with industry dynamics and European market weakness both contributing.

We estimate that severe winter weather in the U.S. negatively impacted segment revenues by about 50 basis points.

The bulk of the revenue decline sequentially versus Q4 2025 is due to seasonality. In the quarter, the VWR e-commerce platform showed green shoots of improved performance in traffic, conversion, and revenue growth rates in the U.S.

and Europe. This followed multiple upgrades as part of our digital roadmap, as well as the successful relaunch of vwr.com.

Enhancing our digital capabilities remains one of our top strategic priorities. Adjusted operating income for VWR was $105 million in the quarter, representing an adjusted operating margin of 9.2%.

The year-over-year decline in margin is due primarily to volume and net price capture. Increased freight costs were also a headwind.

The bulk of the margin decline sequentially versus Q4 2025 is due to seasonal declines in revenues with a number of other puts and takes. There are two key takeaways from the VWR quarter: First, we are pleased with the positive impact our upgrades had on e-commerce performance.

Second, and perhaps more importantly, the VWR platform is stabilizing, with Q1 performance in line with our expectations. We will address this stability again in our guidance commentary.

I will now discuss our other segment, Bioscience and MedTech Products, or BMP. BMP revenue was $431 million in the first quarter, down 2% organically versus the prior year.

This was ahead of our expectations due to better than expected execution from process chemicals and NuSil. In the quarter, process chemicals grew double digits organically due to improving operations and strong order performance.

Fluid handling and NuSil were down double digits in the quarter, due in part to difficult comps, as we had anticipated, while research and specialty chemicals declined about 100 basis points organically. Pricing was positive in the quarter.

Last quarter, we indicated NuSil and the serum and electronic materials businesses within research and specialty chemicals would be headwinds to growth in 2026, and that this comp headwind is primarily due to normalization of idiosyncratic customer ordering patterns and shipments in 2025. In the first quarter, this dynamic in aggregate was a mid-single-digit headwind to the organic revenue growth of BMP.

Adjusted operating income for BMP was $103 million in the quarter, representing an adjusted operating margin of 23.8%. The year-over-year decline in margin is due to inventory provisions, lower volumes, and mix, among other things.

Key headwinds in the sequential margin decline were volume and mix. There are two key takeaways from the BMP quarter: First, our efforts to enhance operations are bearing fruit as our operations showed increased stability in the quarter.

More specifically, BMP back orders declined modestly in Q1, and we have better line of sight to improved operational performance. Second, we had strong order performance in the quarter, with a book-to-bill of more than 1.1 for the whole of BMP.

Order trends were healthy across all business units, and we saw particular strength in our process chemicals order book. I will now turn the call over to Steve Eck to discuss our guidance.

Thank you, Brent. Please turn to slide 8.

We reaffirmed our 2026 guidance this morning, but I want to make a few supplemental comments. In Q2, we expect to generate adjusted EPS of between 19 and 20 cents per share.

Next, as everyone is aware, the Middle East conflict has created inflationary and supply chain pressures that are rippling around the world. At this stage, we are more concerned about the price of raw materials and services rather than their availability, but our concerns could evolve if the conflict persists.

As of today, we estimate that inflationary pressures stemming from the Middle East conflict represent an incremental headwind of approximately $10 to $20 million to our 2026 operating income, and our reaffirmed guidance incorporates this headwind. We have established a task force whose responsibility is to identify, monitor, and mitigate these inflationary headwinds.

Next, on VWR, the financial performance we saw in Q1 was largely in line with our expectations. We believe that VWR is turning a corner, and that VWR's growth rate reached a trough in the first quarter.

We expect that VWR's growth will improve gradually over the course of 2026, with the segment showing positive organic growth in the second half. In BMP, the year-over-year comp headwinds from the idiosyncratic customer ordering patterns and shipments mentioned by Brent in NuSil, serum, and electronic materials will increase sequentially from Q1 to Q2, and we face another tough comp in fluid handling, as well as tougher comp in process chemicals.

Therefore, we expect BMP's year-over-year organic growth in Q2 will be worse than the Q1 experience by more than 500 basis points. There is no new news in these comp dynamics, as our assumptions about their impact are unchanged versus 90 days ago.

We believe that Q2 will mark the low point for BMP growth in 2026. Finally, we expect the adjusted operating margins of both segments to increase sequentially from Q1 to Q2, in line with seasonal patterns.

I will conclude with a comment on capital allocation. Debt reduction remains the top capital allocation priority, and we remain committed to reducing our adjusted net leverage ratio sustainably below 3x.

With that, let me turn the call back to Emmanuel.

Thank you, Steve. I will conclude our prepared remarks by reiterating the key takeaways from the quarter.

Number one, revival is already having a positive impact on the organization. Number two, improved execution has translated into improved operational performance.

Number three, we believe that we are turning a corner financially, and now believe that the growth rate of VWR reached a bottom in Q1, and that the growth rate of BMP will reach a bottom in Q2. This, combined with our tangible revival progress, give me confidence that Avantor will return to positive revenue growth in the second half of this year.

Finally, I want to extend my gratitude to our Avantor associates across the globe for their dedication to serving our customers. Thank you for embracing revival and the new ways in which we are working together.

I am incredibly pleased with the progress we are making together as a team. With that, Operator, we're happy to take questions.

Thank you very much and good morning. My first question, can you talk a bit more about any countermeasures you're taking to offset incremental inflation?

I'm thinking of transportation costs specifically, but it sounds like there are other watch areas as well.

[The noise is pretty safe in whisper?] .

I think, Dan, if I understand correctly your question, you are talking about the measure we are taking against the inflation that we are seeing, is that correct?

Correct. All right.

Dan, first of all, thank you for the question. I think it's important to also review the fact that we have a new Chief Procurement Officer, Keith Borjor, is joining us from Cytiva.

I worked with him a lot in the past. He's a really, really good person.

We've put in place a task force. The good thing about what we see in the Middle East is that the inflation will happen in two area: the first in inbound and outbound freight, and, of course, the team is really looking at our contracts and seeing what we can do on that side.

Then the other thing is a few critical materials, which will not be in short supply, but really where we will see inflation. We have a task force in place.

We're already evaluating the impact. I think Steve in the opening remarks talked about the $10 to $20 million headwind that we are seeing, that we are contemplating in the reaffirming of our guide.

I think it's really in action for us in terms of monitoring, and in terms of seeing what we can pass through our customers.

Appreciate that. Then as a follow-up, Emmanuel, can you talk about the significance of that book-to-bill in the BMP segment?

What is the lead time required to translate that greater than 1.1 book-to-bill to revenue growth?

No, it's a very good question, Dan. Look, I think if we look at what we shared in Q4, our order intake in process chemical was high-single digit in Q4, and with the operation and the revival impact on operation, we were able to deliver a double-digit growth in Q1 in terms of revenue.

The very positive things, and that what we are very encouraged, is that in Q1, our order intake was double digit. There's a sequential acceleration, and it's down again to revival on the commercial side.

A lot of those products are between 30 to 60 days, 90 days lead times. It's also depends of the customer that gave us some blanket order with a lot of visibility.

We have asked the commercial team to work on this, to make sure that, through the S&OP process that we have put in place, we are helping as well the operation to have a good visibility of what is coming. We are super encouraged with what happened in both operation and commercial due to revival.

So, 30, 60 days, 90 days, that's why we are positive and confident about the fact that we will go back to growth in the second half of the year.

Thank you very much.

Hey guys, thank you for taking the questions. I was hoping for just a few more specifics on 2Q, helpful to hear the VWR and BMP pieces.

Can you just talk about overall organic growth, and then also the margins for each, and how we should think about that margin cadence for 2Q and going forward?

Patrick, it's Brent. I'll take this.

Look, I think per Emmanuel's and Steve's, as well as my comments there, you're seeing a bottoming in VWR in Q1, we expect to see continued improvement in that business sequentially. There are more shipping days in Q2 than Q1, even keeping it the same pace that we did in Q1, even though recognizing that's a seasonally lighter quarter, that easily gets us within the range of our guidance there.

Even though on BMP, you'll see lower organic growth, that has to do more with the idiosyncratic comp notion we brought up. It's a nice sequential increase, but not substantial there.

You put those together, you get better fixed cost absorption against that, and then you'll see modest increases in margin against that sequentially. You marry that to revival working in other cost-outs there, and that very comfortably gets you to the range of our guidance.

That's helpful. Then maybe just on the BMP side, helpful comments there, can you just talk about what you're hearing from customers?

Obviously, some mixed data points out there. Are there certain segments you're seeing a little more strength, and then again, I guess the visibility into that recovery and confidence level of that recovery as we work our way into the second half and beyond, just with the market positioning there?

Thank you.

Patrick, I think there's not much change in terms of market dynamic versus what we shared in our last call 90 days ago. Biopharma market is healthy, in particular in bioproduction.

We see that in our order book. This is also particular in process chemicals for Q1 in terms of revenue, but also in order, as I just talked about.

We also see a strong funnel for us. Again, we have with push commercial team to have a better visibility on the opportunity.

We are looking at a strong funnel. Around academy and government, nothing really change.

The market is pretty stable. There's maybe a lower level of activity that what we would preferred, and we continue to assume that customers are a bit reluctant to spend money in that part.

NIH funding is stabilizing, catalyzing incremental demand that will represent upside potentially. Again, if the customer decided to spend their budget.

Bottom line is that the end market behave exactly as we were expecting it, all right? I think if there's no assumption that there's major change during the year.

I just want to maybe add one comment. We shared in the past that despite the difficulty that we had, we never let down the customers, in particular in bioprocessing, and I think we can really say that each time that I meet customers, there is a strong feedback about the service level and the engagement that we have, and this is again reflected in our Q1 order book and the book-to-bill, which is 1.1x.

Thank you. Brent, just to close the loop on 2Q, is there a specific organic number you can give?

Thank you, guys, so much.

You're probably talking about a decline of 500 basis points there for the quarter on top line.

Thank you.

Yep.

Hi guys, congrats on a good execution here, and thank you for taking my question. Brent, wishing you the best as your transition here.

Maybe, Emmanuel, I heard the term confidence in the business bottoming out. It sounded very constructive.

When you think about VWR bottoming out in Q1, what gives you the confidence that VWR has bottomed out? Brent, if VWR has bottomed out in Q1, why is 2Q organic -5% when you guys just did -4% in Q1?

We're talking about at the firm level there, Vijay, you're going to see more decrementals in BMP taking the firm rate down to -5% there. You'll see a sequential improvement in VWR and then going backwards by 500 basis points or more in BMP.

I was going to add that around VWR. I think we had a strong reset of VWR last year.

We shared with you that we've lost market share. Q1 was really the tail of those market share lost.

We have really stabilized the situation with VWR. We also look the order trend, okay?

We look at the contract conversion, the new contract we win. We measure the engagement of our commercial team.

Everything that we're doing on VWR, in particular around the e-commerce channel, has been executed phenomenally well. We're super happy with that.

We're strengthening the team with talent. I think this is why we're expecting stabilization really of Q2, and then onwards positive growth.

Understood. That's helpful.

Maybe one follow-up, Emmanuel, for you. If we're starting first half somewhere down mid-single digit, -4% to -5%, what improves in back half, right?

Is it just comps getting easier in back half, or is the business turning? Is there a bridge from first half to second half, how we get to positive growth in back half?

Sure. I think this is what we said in our opening comments, all right?

Q1 bottom for VWR, Q2 bottom for BMP, stabilization of VWR, and then we have the order book that we just talked about, which is really encouraging on the BMP side. I think, basically, the confidence about the impact that revival has on the commercial intensity, on the operational excellence, and also on the fact that we are bringing all those talents, which some of them are already having an impact, and there's many more coming.

I think this is a combination of all of this that gave us confidence that second half will be back to growth. Of course, easy comp as well in terms of VWR in particular.

Vijay, taking the comp piece aside, not a dramatic sequential increase that we have baked into the plan, certainly Q1 to Q2, and then we aren't getting more specific on the back half or broadly beyond that, and just to be super clear into Q2, you'd say about -5% at an enterprise level, improvement in VWR coming up sequentially coming off a -5% in Q1 and then going backwards about 500 basis points more in BMP, you can put that math together and gives you a clean picture for that, that does not require a significant sequential ramp for the company in Q2.

Understood. Thank you, guys.

Hey guys, thanks for the questions. Maybe as you look across your manufacturing and logistics footprint, I guess what portion of facilities would you say are in good shape today versus still needing some investment?

I think you mentioned you've greenlighted 12 projects. What kind of investment do those projects entail, and what's the timeline to complete those?

Thanks, Catherine. Look, I think I visited probably all of them.

I think there's maybe a few factory where I have not been, like India, which I'm planning to go by the end of May, and maybe one or two in the U.S. I don't have yet the complete picture of all our sites.

Look, we have excellent sites. I was recently in Poland, and Briare in France, and Leuven in Belgium.

I think, generally speaking, look, in terms of project, there's always project happening in every site, all right? There's not one site that consume all our capex or not.

Every site has a project. We encourage every leader to look at how to apply Lean and kaizen on the site to make sure that we have productivity, okay?

I think Mary is driving a huge improvement on that side, where we are measuring the productivity by site, and therefore every site leaders are encouraged, with the help of our internal Lean team, to come back with project that are going to create productivity, and we just shared one of them. Those projects are very different.

We did 12 in Q1, but I think we will have more coming on into the rest of the year, and I think this is where we are encouraged, is the team is responding very well in this.

Great. Then can you just walk through how the BMP idiosyncratic order pattern comps space throughout the year?

I think you said they were a mid-single-digit headwind in 1Q, will be higher in 2Q, but how does that look in the back half, and does BMP get back to positive growth at some point in the back half of the year?

The idiosyncratic gets a little better in the back half of the year. As you recall, the primary driver in the back half is going to be headwinds in electronic materials there, and I would just continue to think about sequential improvement here, and that's really the theme we're really trying to talk through here, is sequential stability, then modest growth against that.

I think we've shared in the past call that NuSil, serum, and electronics had actually different timing in the past. NuSil, serum giving headwind first half, electronic material giving headwind in second half.

I think this is important for us to continue to work with the supply chain team, but also with our customers, so that we come back to a normalization of the customer ordering pattern, and therefore shipment across the year.

Great, thank you.

Great. Thank you for taking my questions.

Maybe just start, can you walk through the price versus volume performance in the quarter? You said pricing was positive in BMP, assuming that was down in VWR, some more color on pricing in the quarter and updated pricing expectations for the year would be helpful.

Would also be curious to hear your updated thoughts around gross margins and where those could land on the year, just given some of your comments around freight costs and such.

Casey, broadly in the quarter, and let's talk about this on the gross margin side, and I think the right way to think about it is sequentially. We talked at the last call about taking the 31.5% adjusted gross margin as a jumping off point to think about this year.

On a total company basis, you really had the decrementals on volume offset by pricing actions that came from the beginning of the year. Then you have other puts and takes with freight and etc.

there. We saw somewhat better performance there.

We like that. We believe that will continue to grind up during the year.

On a full year-over-year basis, price cost spread was negative. Again, that's due to the VWR margin reset we saw beginning in the second half of last year, but we like the setup for that, we like the execution, and then we believe you'll see a grinding up certainly into Q2, and then we're not being more specific about the back half of the year, but certainly our guide is predicated on that gross margin improvement.

Understood. Then as a follow-up, can you just talk briefly about free cash flow performance in the quarter?

You did $25 million here in 1Q, but reaffirmed the $500 to $550 million guide. Just curious if the free cash in the first quarter was in line with your expectations, and I guess the guide does imply a pretty big step-up moving forward, maybe just walk through how you plan on getting there, the puts and takes, and any sense for just phasing and how back-end loaded that range is.

Thank you.

No, certainly, Casey. We noted that it was consistent with our expectations.

Our guide is before restructuring expenses, then it was around $40 million when you exclude restructuring expenses. We cited the significant pre-bate.

If we had not had the significant pre-bate in the quarter, we would have looked a lot more like last year, and then we would expect a similar sort of ramp throughout the year. There weren't really any other significant moving pieces.

If you look at the cash flow statement, there weren't working capital swings or otherwise that drove it differently. Really, the story in the quarter on the relative was the pre-bate, as well as on the absolute on the year-over-year lower earnings.

Again, it's not unusual for Q1 to be lower on a seasonal basis, and then you'll see strong continued sequential improvement, which you've seen from us historically.

Got it. Thank you very much.

Yep.

Got it. Understood.

Thank you.

Hey, thanks. Good morning.

Emmanuel, on the VWR business, you talked about some market softness in Europe. Did that region deteriorate sequentially or is that just a year-over-year comment?

Then the 50 basis points of US of of weather impact in the US in the quarter, I guess I would have thought you would have made up those orders at some point in the quarter. Did those get pushed out to 2Q?

How do I think about, the impact of that or is that just lost revenue in general? Thanks.

Just on the weather, I think what we were saying is it did impact, but fortunately, the team worked very well and finished to deliver what we were expected. VWR in Q1 was really spot on in terms of our expectation.

Again, another confidence about the team capable of being flexible and really make it works. That's the comment on.

On Europe, I think there is some softness, in particular in the industry in Germany and couple of area like this. Also, I think remember that in Europe, we're the number one.

We're very proud of being the largest distributor there, and so, it's the places where the market is when you are the number one always impact you a bit more than anybody else. I think, look, it's an area where we didn't have a leader for a long time there.

I think we've Christoph now, which is really taking care of that. We did some reorganization, and the team is reinvigorated right now, and so that's where we have confidence in the second half in Europe as well.

Gotcha. Then maybe Steve or Brent, on the inflationary impact of $10 to $20 million, nice to see you're able to absorb that in the guidance for the year.

Two questions: Do your contracts generally allow for freight-related surcharges to be passed through? Number two, to what extent have you kind of, I guess, stress tested those assumptions?

Are there other known unknowns that could push you above that range as we look out next few months that you're worried about? Thanks.

Brandon, let me start just a quick comment on the contract, and then I let Brent and Steve answer for the rest. We've tested that during COVID and post-COVID inflation, I don't know if you remember.

We have a tool in place for surcharge. It's working well in some area, in geographical area.

Other geographical area, it's a bit more difficult, but we are looking at the success story that we had post-COVID when we had huge inflation, and we are just putting a team in place to make sure that we reproduce that, and not only one in one geography, but across the entire territory. The answer is yes.

Maybe not every contract, but a huge majority of this. Just to

follow up Emmanuel's point there, Brandon, as you can tell by this estimate of $10 to $20 million, we're providing a range of potential headwinds we see in the year, related to the Middle East conflict, that we're carefully watching that situation and estimating the impact that it could have on our operating income. Like Emmanuel said, we are monitoring weekly and looking for every opportunity to mitigate that impact on our results the best we can.

Brandon, I'd just add, you coined a phrase 'known unknowns' there, I suspect. I don't know if we can ever know an unknown,

but

we certainly thought very deeply about this, we think we identified that appropriately.

Great. That's helpful.

Thanks.

Hi, good morning. I wanted to ask about the bioprocess portfolio.

You referenced BMP as a category having down slightly in 2Q and then improving in the back half. Many of the bioprocessing peers, I think at this point, are closer to normalized growth in the high single digits.

Emmanuel, just curious if you think on a long-term basis, as you've had a chance to really review the business, if this is a portfolio that you think can grow kind of at that market rate, and maybe how long you think it will take to get back there?

No doubt. Look, the BMP negative growth into Q2 that we are anticipated and for that segments to be at the bottom in Q2 is mostly due to what we talk about, the seasonality and the idiosyncratic purchasing that we've seen, in particular in serum and NuSil last year, all right?

It's a comp. When you look at really what is the core of that segment, which is process chemicals, we've seen double digit in process chemicals in Q1 in revenue, but also in order, a positive book-to-bill.

We think that the market is 6%, 7%, like our peers looked at it, and we are really pushing the team to make sure that we are growing at market or even above market for the rest of the year. Again, the focus that we've done on revival around commercial intensity, as well as operation, give us confidence that we'll go back in second half of the year to growth on both segments, and we're getting every day, we're getting more optimistic about the business.

That's great. Then, Emmanuel, you joined last July, and so I've been there almost a year.

You referenced 25% of kind of top leaders changing and a number of folks that you've brought in from other companies. In response to Catherine's question, you've been out to most of the facilities.

I guess, where would you assess in terms of the structural, kind of personnel changes that you'd like to make, any kind of actions you wanted to implement and get going? Where would you say you're at in terms of getting that started, and really ready for the company to jump off, versus additional structural changes that you think need to be made to reposition the company?

Matt, this is a very good question. Let me first, because I like to be precise, I joined mid-August exactly, it's not yet a year, all right?

Give me a bit more time to celebrate my anniversary. Super happy about, first of all, the reaction of the team internally, all right?

We have some really good talent internally, there's absolutely no doubt. What we're trying to do is just combine this internal talent with additional external talent.

Some of the roles that we've shared today, and that we are in that early slide, are role that we have created, that we didn't have in the past, okay? I think where I am today, well, look, I need a strong right-hand person, and the CFO search is on its way, someone that can really be my partner to really continue to push and execute revival.

I would say, generally speaking, at my anniversary, in a couple of more months, I think we will be almost there. We will announce soon some additional executive member that we should be able in position in a couple of weeks to share with you around QRA and CIO, and I think we will be there.

Nevertheless, let me just say one more thing. Talent is always something which is very dynamic as well, okay?

What we are trying to do is to make sure that we do not lose the talent that we have as well. This is always something very dynamic, and I think we are constantly making sure that we are motivating our talent, and one of the things that we're doing in revival around simplification is also about changing the delegation of authority to make sure that we empower the right people to make the right decision at the right place, at the place of impact, as close as possible to the business.

I think, again, this is something that the team is reacting very quickly and very nicely, and I think the first quarter, we're pretty happy with our results, and we are very optimistic about the rest of the year.

Great. Thanks for taking the question.

I've got a couple minor ones I'm going to throw in. First, you alluded to pre-bates a number of times.

Just wanted to see if you could expand on that, just sort of the magnitude of it in the quarter, was that unusual for 1Q, just sort of the impact that had on numbers, and just how to think about that going forward?

Michael, it's Brent. Pre-bates are associated with enterprise contracts with large customers.

We started talking about that in Q2 or Q3 of last year. We had a meaningful impact of upfront payments due to that in Q4 of last year.

We're not specifically quantifying it, but it had very significant impact on the cash flow, but let's also be clear, it was anticipated, it was expected in our guidance, it was expected in how our cadence was going to go.

Michael, I will also look at it in a sense that if you do not renew and do not win contract, you don't have pre-bates, I would look at it as well as a positive.

Okay. Then on the VWR business, I hear your comments about 1Q, you expect that to be the organic low point, and you talked about some improvements 2Q and beyond, you've got easier comps in the second half.

Still, you did post a -5% organic print on a -3% comp. Could you just talk about share dynamics, share gains, share losses, maybe touching on the pre-bates and the enterprise customers there, just confidence that that's really stabilized and there's going to be less and less of an issue going forward?

We talked about last year, we had some share lost. I think I explained as well that you don't lose share at a one-off, all right?

It's a headwind that goes month after month. It takes time for our competitor to convert the win that they had, which is more or less on paper at the very beginning.

This is where we are. We are first of all on a seasonal low quarter.

We are at the tail of those losses, and we talked also about the fact that last year, we renew contract with opportunity to grow, license to go hunt, and this is what we are doing. We're happy about what's going on right now.

We had that tangible point which is stabilization of our commercial activity. We win contract, we renew contract, we lost some contract, we lost some share within a contract, the customer gave us a certain share of wallet.

There's a huge dynamic here. What I can tell you is we are stabilizing, and that's the most important things.

It's a stabilization. As we are moving into the second half of the year, we have an easy comp.

That is because we are stabilizing, because we are taking the action that we are taking, in particular in e-commerce, that we are confident about the fact that Q1 is the bottom.

Okay. If I could squeeze in one small follow-up.

To Patrick's question, I think he pushed you on 2Q organic and margins. I want to make sure I understand the margin cadence properly.

It sounds like you're pointing to some gradual improvement through the year, including on the gross margin line, but just looking at prior seasonality, that seems to go against that. Is there anything unusual in gross margin that I'm missing for this year that would explain that?

Thanks.

Michael, I think we're coming off sort of the rebase for the company. We have significant revival productivity initiatives.

There's always the noise of mix within that, and we're also not pointing to a heroic improvement in that, just the kind of classic revival productivity and other things along with just better top line, better absorption against it.

All right. Thank you.

Hey, good morning, guys. Thank you.

Brent, just curious, how much of the plasticware portfolio within VWR is yours versus OEM? I ask as I'm just sort of thinking about oil sensitivity and resin input cost, trying to understand how much you have control when it comes to managing inflation just versus sort of being at the mercy of whatever the OEM provider decides to do on price, etc.

Dan, Emmanuel here. We have a huge portfolio, and I don't have the data, and I'm looking at Brent right now, I don't think we have the data in front of us, I apologize, this is something that we can follow up.

What I can just reassure is we have also a new sourcing leaders in VWR, and Emily is really leading that, Emily and Keith are really working hands-to-hands in the task force to make sure that we are controlling and making sure that we are negotiating best deal we can, and passing through the increase we may see.

Fair enough. Maybe just sort of looking ahead a little bit and thinking about 2027, which I know is a long ways away, but does the operational improvement that you feel like you have confidence in right now, does that give you confidence that EBITDA margins will be up next year?

Let me answer in two parts. Let me echo comments from others already.

It is April '26, it's a bit premature to talk about '27, and I just want to reiterate what I said in the past. I take my comments very seriously, and for me, it is just too early to put a detailed stake in the ground.

However, and having said that, I'd like to make a few more observation on the future. Look, today, we are pleased with our Q1.

We are looking into a second half of the year which is going to be positive, and we are optimistic about that. Revival is having an impact, and I'm confident that revival for the rest of the year will have a greater impact.

We feel that we will exit 2026, and by the end of the year, I think as well that we will have more capital deployment flexibility, a higher level of confidence across the organization, and revival is going to accelerate to have an impact on the entire organization, around commercial team, around operational team, around the rest of the support functions. All what I see today over the last now nine months almost, give me confidence and I am optimistic that 2027 will be a growth year.

Appreciate that. Thank you.

Operator, we have time for one more question, please.

Great. Thanks for the questions.

Maybe just on the distribution business, could you just zoom out and talk to what you're seeing in kind of the broader market? There's a lot of uncertainty, what's happening with pharma spending, certainly in the US, academic, government trends.

I'm just wondering versus what you're delivering, kind of how's the broader market doing? Then related to that, are you guys assuming positive price in the back half of the year?

Do you want to answer the price for the back half of the year?

Dan, we have very modest price baked into our plan here. Then

I think from an overall market, I would say what I just said three months ago, I think we are where we are. Academic and government stable, maybe at a low level.

Education segment is a question mark. There's pocket in Europe as we discussed about, that include industrial that are really struggle given the macroeconomic environment.

There's geography differences. Again, we are in so many different segments, including mining and pharma.

Look, we are thinking that from us, and that's very important, we are stabilizing, the team is motivated, we are implemented the plan that we have, in particular in digital, we're super happy to have our new Chief Digital Officer, Jens Fien, and that will really help us to think that the market is probably at a low-single digit, and we will be back to growth in second half. I think this is where we are today, and of course, we will continue to monitor the macro environment on this.

Maybe just a final one. I know you called out that material headwind in 2Q from the BMP across those different businesses.

Sounds like it's idiosyncratic, very company specific, but you've got, it's pretty big. Could you provide any more color on that, like the NuSil, serum, and then sounds like, Brent, that the electronic materials is a headwind in the back half of the year.

Sorry if I missed in prior calls you guys discussed those, but any additional color you can provide on those would be helpful. Thank you.

Look, I think, Dan, I think we've talked about it broadly where it comes as a headwind, but in the first half of last year, due to some timing both customer orders and our fulfillment, you saw very, very strong performance in NuSil. Now, that also has very strong margin contribution.

That's a headwind right now. You also saw very strong performance in serum, then in the back half of the year, we saw exceptional performance in the EM business, particularly in Q3.

NuSil, we talked about discretely, but for the research and specialty chemicals piece of it, that EM and in serum just provides a headwind in the front half and the back half that just makes the segment comps more difficult. That's why you see us calling out specifically how we're doing process chemicals and other pieces there, they're unburdened by those comp pieces, and I continue to point you all to the sequential performance we have in these through the year, moving away from the pieces on the comps.

All right. Thank you, Steve.

Thank you, Brent. Thank you, everybody, on the call to joining us today.

We moved the company forward in the first quarter, and I'm encouraged by the momentum and positive energy across the organization. Revival is having an impact.

Avantor is turning a corner financially, which gives me confidence that we will return to positive growth in the second half of the year. I look forward to updating you again next quarter, and until then, be well everyone.

Thank you.