T. Rowe Price Biotech ETF (TDNA) is a fully transparent, actively managed exchange-traded fund sponsored by T. Rowe Price Group, Inc., a Baltimore-based investment management firm founded in 1937 and headquartered in Baltimore, Maryland. The fund seeks long-term capital appreciation by investing primarily in biotechnology companies and related emerging technologies that the manager believes may improve the treatment and cure of disease and enhance quality of life; it normally invests at least 80% of net assets in biotechnology securities and is designed to concentrate more than 25% of assets in the biotechnology sector. TDNA is listed on Nasdaq, is expected to hold approximately 60 to 120 companies, and carries an expense ratio of 0.55%. T. Rowe Price offers the ETF within its active ETF lineup alongside other equity, fixed income, multi-asset, digital assets, and thematic strategies, serving financial intermediaries, advisors, and other institutional and retail investors seeking active public-market exposure. In September 2026, T. Rowe Price launched TDNA together with two other active equity ETFs, marking a recent strategic expansion of its ETF platform and adding a new biotechnology-focused vehicle to its product suite. The fund is managed by John Hall, who has 11 years of investment experience at T. Rowe Price.