Good morning, and thank you for joining Medpace's first quarter 2026 earnings conference call. Also on the call today is our CEO, August Troendle; our President, Jesse Geiger; and our CFO, Kevin Brady.

Before we begin, I would like to remind you that our remarks and responses to your questions during this teleconference may include forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements involve inherent assumptions with known and unknown risks and uncertainties, as well as other important factors that could cause actual results to differ materially from our current expectations.

These factors are discussed in our Form 10-K and other filings with the SEC. [unclear] to update forward-looking statements, even if estimates change.

Accordingly, you should not rely on any of today's forward-looking statements as representing our views as of any date after today. During this call, we will also be referring to certain non-GAAP financial measures.

These non-GAAP measures are not superior to, or a replacement for, the comparable GAAP measures, but we believe these measures help investors gain a more complete understanding of results. A reconciliation of such non-GAAP financial measures to the most directly comparable GAAP measures is available in our earnings press release and earnings call presentation slides provided in connection with today's call.

The slides are available in the Investor Relations section of our website at investors.medpace.com. With that, I would now like to turn the call over to August Troendle.

Good day, everyone. Before reviewing Q1 results, I would like to acknowledge that this will be our last earnings call with Jesse Geiger, our President.

I would like to thank Jesse for his 18.5 years of service. Thank you, Jesse.

Quarter 1 of 2026 saw cancellations rise again, with backlog cancels reaching their highest point in over a year. Net bookings were below the level of seen in Q4, but well above those in Q1 2025, with a net book-to-bill ratio of 0.88.

RFPs were down in the quarter sequentially and year-over-year. Initial award notifications and win rate were strong.

We continue to view the quality of opportunity flow as good. While there's nothing we can do to alter our cancellation rate, we are focused on expanding our pipeline of opportunities and have implemented a number of initiatives to improve our win rate.

Jesse will now comment on Q1.

Good morning, everyone. Revenue for the first quarter of 2026 was $706.6 million, which represents a year-over-year increase of 26.5%.

Net new business awards entering backlog in the first quarter increased 23.7% from the prior year to $618.4 million, resulting in the 0.88 net book-to-bill. Ending backlog as of March 31st, 2026, was approximately $2.9 billion, an increase of 2.9% from the prior year.

We project that approximately $1.94 billion of backlog will convert to revenue in the next 12 months, and backlog conversion in the first quarter was 23.3% of beginning backlog. Now, before I turn the call over to Kevin, I want to add that it has been a true honor to serve the company all of these years.

I wish all of my Medpace colleagues well, and I'm so proud of what we've accomplished together. With that, I'll turn the call over to Kevin.

Kevin?

Thank you, Jesse, and good morning to everyone listening in. As Jesse mentioned, revenue was $706.6 million in the first quarter of 2026.

This represented a year-over-year increase of 26.5% on a reported basis and 25.8% on a constant currency basis. EBITDA of $149.4 million increased 25.9% compared to $118.6 million in the first quarter of 2025.

On a constant currency basis, first quarter EBITDA increased 28.6% compared to the prior year. EBITDA margin for the first quarter was 21.1% compared to 21.2% in the prior-year period, as the impact of higher reimbursable costs were offset primarily by lower employee-related costs.

In the first quarter of 2026, net income of $123.9 million increased 8.1% compared to net income of $114.6 million in the prior-year period. Net income growth below EBITDA growth was primarily driven by a higher effective tax rate in the quarter.

Net income per diluted share for the quarter was $4.28 compared to $3.67 in the prior-year period. Regarding customer concentration, our top 5 and top 10 customers represent roughly 28% and 37% respectively of our last 12 months revenue.

In the first quarter, we generated $151.8 million in cash flow from operating activities, and our net days sales outstanding was -58.8 days. As of March 31st, 2026, we had $652.7 million in cash.

Our 2026 guidance ranges for revenue, EBITDA, net income, and EPS are unchanged from our prior quarter, based on an effective tax rate of 19% to 20% and interest income of $27.5 million. There are no additional share repurchases in our guidance.

With that, I will turn the call back over to the operator so we can take your questions.

Hi, good morning, everyone. Thanks for taking our call.

Maybe just following up on the cancellations point. August, I know you mentioned the highest that you'd seen about in a year.

Just wondering if you could dive into the dynamics behind those cancellations. I know last quarter you called out not really macro-related, more project-specific.

Wondering if that was the case here in the first quarter, and then any detail you could provide around how cancellations have trended so far in the second quarter, and just any other drivers in terms of therapeutic modality, indication, any sort of themes behind the outsized cancellations that you saw here in the first quarter? Thank you.

Sure. Hi, Max.

Cancellations were again just the kind of random stuff you'd expect, product performance, reprioritizations, etc. It wasn't particularly informed by acute, financial shortages or anything like that.

It was just kind of usual thing, but, higher than, historically we've kind of average and and, gave gave pressure on our book-to-bill. Cancellations in the quarter were I, I think the largest, therapeutic areas kind of were oncology and and cardiovascular, which is kind of kind of usual anyway.

Really nothing to call out there. Second quarter, it's it's really I think too early to get any kind of read on cancellation rate and whether it's going to, be be high again in in Q2.

I just have I think it's too early to make any kind of assessment of that.

Understood. Maybe following up on and sticking on the cancellations theme, I think last quarter you also mentioned cancellations were both in terms of your backlog, but also in that initial awards bucket.

I know a couple of quarters ago you called out, I think, the initial awards bucket you had about $4 billion worth of signed work in there. Just wondering if you could provide any update around cancellations out of that bucket in particular and where the size of that bucket today relative to maybe that $4 billion that was at a couple quarters ago.

Just trying to get a sense for your visibility and level of confidence into that initial awards bucket converting into backlog moving forward here.

Look, we're not going to get into kind of our pipeline size, etc. We've never quantified that.

Really, cancellations in that bucket though were not particularly elevated in the quarter in Q1. It was more backlog-related cancellations that were problematic for us.

I don't think that impairs our future things rolling into backlog. I think the last couple quarters of high cancellations overall and across everything, including our pipeline of opportunities in prior quarters does influence it.

That was not a particular factor this quarter. Obviously, the higher cancellations take away from the total revenue opportunities in the year, but future conversion hopefully, with a reduction in cancellations, if we hopefully see that, can proceed at a kind of more normalized rate.

Alright.

Thanks again for taking our questions.

Cool.

Hi, thanks for taking my question. Good morning.

I wanted to clarify on the cancellations comment to Max's question. August, you said oncology and cardiovascular.

I believe you all would treat cardiovascular independent of metabolic, and I just wanted to make sure I heard that right and that we're interpreting that correctly. Metabolic cancellations were actually not part of your call-out.

Is that correct? That That That's

That's correct, and we we break out our therapeutic areas in our earnings release in our, our

In the deck, yeah. Yeah.

presentation, the deck that comes with it. Cardiovascular, yes, is separate from metabolic.

Obviously, there are programs that are are sometimes very one product if it's cardiovascular-focused versus metabolic, sometimes there's a little bit of overlap, but we do break them out.

Okay. I think a market concern is metabolic has been a significant revenue growth driver as evidenced by the pie chart that you include in the deck as you referenced.

I think the call-out on the fairly sizable cancellation that shaded down net bookings last quarter was metabolic, and so maybe you could speak to I think I asked you this last quarter, but do you have a GLP-1 concentration that is becoming more volatile perhaps because of changes in price in the market, dominance by a couple of players that would cause biotechs to think twice about whether pursuing GLP-1s? That's, I think, a thesis that is out there, and I wondered if you could provide some color as to whether you have that exposure or not.

Certainly we have I think we talked about about 50% of our I think we talked about 50% of our obesity work was GLP-1 directly related, etc., and gave a few metrics on that last quarter. We have a fair amount of work there, but I don't really see that as more volatile.

I think in terms of new opportunities, there may be some truth to what you say in terms of the market becoming a bit saturated and competitive and pricing sensitive, but it has not resulted in higher cancellations, and even in pre-backlog. You have to realize If you look at historically quarter-to-quarter cancellations as percent of opening backlog, just like we do for our total backlog percentage cancellation, of all the therapeutic areas we break out, metabolic has the lowest historically cancellation rate.

Last quarter because metabolic is large and it happened to be a little bit of an uptick, and oncology had a little bit of a downtick in percentage, metabolic happened to be higher. Generally, oncology is a riskier field and has more cancellations.

I didn't see the disruption that you kind of described, maybe others are seeing. GLP-1, there's a lot of work, there's a lot of stuff.

It's actually a pretty safe therapeutic area for us, and things are going fine.

That's helpful. Last one for me.

On kind of the revenue guidance and cadence, given the immediacy of your bookings recognition to revenue, when you recognize a booking, the project is kind of already going, and you're highlighting higher cancellations, a sub-1 book-to-bill, you're maintaining the revenue guidance. Perhaps you or Kevin could speak to the kind of the durability or the ability to hold the revenue where it is despite backlog not really growing.

We'll let Kevin talk in a minute, but just on the surface of it, under 606, revenue is a tough one. We've not been really great at predicting just when pass-through investigator costs are going to hit, and they're a larger portion of things lately.

Look, that's always at risk, but our current modeling is we're going to be within our guidance range on revenue despite the cancellations. Certainly, we have to worry about future cancellations.

Kevin?

Yeah. Understood.

Thank you.

No David, you have that exactly right. Despite the headwind from cancellations that we saw in the first quarter, we feel very good about the range that we have out there, which is why we reconfirmed guidance.

Certainly, future cancellations could potentially impact that because cancellations can have a more near-term impact on that. Right now, we feel good about the guidance ranges that we have out there.

Got it. Thank you.

Great. Thank you.

Good luck, Jesse. It was nice working with you.

On the gross booking side, can you give us what the gross bookings grew and if it was in line with your internal expectations?

We don't break out gross bookings. We just report on net bookings.

Directionally, was it in line?

Was it overwhelmingly cancellations that drove us down from what would have been a great book-to-bill? No.

New gross awards were also on the low end, and that's why it was a combination of the two, both cancellations and weak gross bookings, obviously impacted by prior pre-backlog cancellations in the past.

Okay. Then, I get the question a lot, there's a lot of biopharma M&A buying biotech.

How should we view your exposure to that going forward? If a big pharma purchased one of your biotech companies, what happens in that scenario to current trials?

That's frustrating. It happens all the time.

It's happened in the recent past, and it continues to happen. Clients of ours get acquired.

Generally speaking, we are cut out on future work. It's a loss for us.

Usually, the ongoing work we continue with, although there's even cases where they sometimes decide they're going to fold that into their current provider or internal resources. Acquisitions are not good for us, no.

It happens all the time, and we have a very broad portfolio of clients. It's something we work around.

Thank you.

Yeah. Thanks for taking the question.

Maybe if I could first follow up on Ann's question. Would you attribute any of sort of the heightened level of cancellations as a result of past M&A?

No, I don't think any of the cancellations we had in the quarter were related to any M&A activity, no. Maybe I'm wrong on some little, smaller part, but that was not a driver of anything, no.

Okay. Then maybe just two more things around that.

You talked about sort of what normally drives cancellations, either reprioritizations or drug fails. Could you give us a sense for the mix in the cancellations perhaps between drugs that were canceled sort of in flight or because of futility, or kind of canceled ahead of start because of sort of a change in direction by the sponsors?

No, we don't even track that because to even categorize it is difficult because they're overlapping buckets. Nothing struck us as specifically funding-related, which we are sensitive to and try to get a feel for the overall funding levels in the market.

Funding is always one of the factors. If everyone had unlimited resources, a lot of stuff would move forward that they're canceling because of product performance.

They're just so overlapping, we don't even try to break that out.

Got it. One last quick one for me.

In the bookings that you did sign in the net bookings, the level of pass-through revenues expected in the future work, is that at the same current rate that you're seeing today, or is it lower? In other words, maybe there's a mix difference, and therefore, obviously, we have a higher level of pass-through revenues reported this quarter, but maybe pass-through is expected in the new work a lot less, which could skew the metrics?

Kevin?

Yeah. Charles, I would say that in terms of the current bookings, I would say there's still somewhat of an influence in the higher pass-throughs.

As I had mentioned last quarter, I do expect your pass-throughs as a percentage of revenue to end the year lower than what we started this year at. We were pretty high this quarter at 44% or so.

I do expect that to come down as some of these metabolic studies wind down a little bit. It all depends on kind of future work and future bookings as well.

Got it. Appreciate the comments.

Thank you.

Thanks very much. I'll hit this cancel topic a different way.

Bear with me. Historically, you have an average cancellation rate.

I know there's lots of volatility around that, but you have an average, and I'm just curious if cancels were average this quarter, understanding that gross awards were lower than you would like, but if the cancels were average, what kind of zip code book-to-bill would we have been looking at? Would it have been a 1.0, a 1.1?

Where would you have been if the cancels were just normal, and all else constant?

What normal is, just kind of pick the middle of the range or something. I really haven't done that math, but Eric, I think directionally, yeah, it would have been still a weak book-to-bill, somewhere around 1.0, I would assume.

It wasn't just massive cancellations that knocked us down from a great 1.15 to 0.88. It was a mixture of the two.

Then

if I could play off that a bit. Sometimes these rates are impacted by one larger, two larger, three larger cancels.

What would be the quantum if your largest cancel hadn't happened, would you have been normal? Was it three?

You're talking about several, yeah, two, three to drive you over. There was no very large one or something like that that drove it.

Some of them are meaningful in size, but no, there was no one or two that were outsized that drove it.

Okay. Then last one for me.

Wait a minute, just let me make one more comment. I say it was weak bookings and cancels, kind of both were factors here.

If cancels had been much better range, we would have had a better book-to-bill, but it would have been weak anyway. Even if cancels were relatively low, would have been a poor book-to-bill.

That low book-to-bill was something of a just what's progressed and what's in pre-backlog and what's canceled there and never is matter of moving forward. Also, some things were just timing of things that move forward.

Some of that, you hope, will eventually make it to backlog in future quarters.

Yeah. No, that's that's understood.

One last thing. The the the backlog that you show to the Street, you have a next 12 months revenue visibility figure and a total backlog figure.

You subtract the next 12-month visibility figure from the total, over time we've seen a deterioration in the backlog coverage that is beyond one year, years two and years three. You've had six consecutive quarters of that that number coming down.

I'm just, walk us through why there isn't I think, you and I spoke a quarter or two ago about, this view of this effectively being like a a drug patent cliff for a big pharma or something, that there's something looming a year-plus away that's going to completely upend the revenue growth profile. In the past, I sensed that you weren't concerned about that, but but the Street is.

I'm just hoping you can talk us through the mindset of why seeing this plus-one-year backlog decline maybe it is now a concern for you, but I I'd love it if you could talk through that thesis, that thought process of why we shouldn't be so focused on this or or maybe we should, and what it would take to get that number going back in the right direction if you are concerned. I think this is sort of the elephant in the room that a lot of people are looking at, and it would be helpful if you could could really dig into that for us.

Sure. No, and I I guess there is area for concern, you know.

I I several quarters back, I it wasn't a concern because our pre-backlog was growing so fast and and I thought cancellations were, coming down and going to be, in a good place. That really, frankly, hasn't happened.

Cancellations have continued to go on at a much higher rate, both in backlog and pre-backlog. It does now result in us facing a, revenue You project, just look at the year Q1 versus remainder of year, we don't have revenue growth, on a, we will on a year-over-year basis, but not on a, quarter sequential quarter basis.

'27 is, I don't know yet, you know. That's that's too, too far out at this point to really get a handle on.

No, our growth profile, both now and six months from now, in terms of, sequential growth, is, real question. We need we need an you need either back cancellations to abate, or gross awards, new notifications and, a bigger pipeline going forward.

That's why I talked about us trying to expand our pipeline and, really kind of accommodate, what could be a much higher cancellation rate than we're sort of used to in in, in historical, periods. No, I I I mean I can't I can't dodge it and say, "Oh, yeah, yeah, no, there's no there's no issue there."

Certainly, what we consider a a reasonable growth rate is not projected, on a on a sequential basis going forward.

I appreciate the candor. Thanks very much.

Good morning, and thanks for taking my questions. I want to follow up on your comments earlier about RFP trends.

I think you said that they were down year-over-year. Can you elaborate on that, any particular areas you're seeing weakness?

With biotech funding remaining stable over the past 8, 9 months, surprising to see RFP weakness. Just can you give some more color on that?

It's hard to categorize what sector, what therapeutic areas or what's weak, etc. I really don't have those kind of metrics.

I don't even, frankly, pay a lot of attention to it. Now, it is a focus of the industry overall, and everybody talks about RFPs.

I feel compelled to do it. As I've said many times in the past, I don't really pay a lot of attention.

Certainly, a long-term trend of decreasing RFPs is obviously not viable. The bouncing around of RFPs is overwhelmed by the quality of the RFPs.

There's always the question of, is more RFPs means that they're just inviting more CROs to the same RFPs, or are there really more RFPs out there? Just measuring it is very difficult.

I tend to just ignore the numerical value on a sequential basis or single time points, and focus on the quality of the opportunities we have. I believe we have very high-quality opportunities, and I haven't seen a deterioration of that.

I don't feel like I have talked about at sometimes in the past of real funding problems, and a lot of just scenario planning, and fundraising, and all the rest of it, that they're just looking for bids so that they can go out and try to get it funded. That has happened in the past, and I do not see that in the present to a large extent.

Obviously, that's something that happens all the time, but the trend is actually pretty good. I don't put a lot of stock in just the numerical value of RFP that we see in a given quarter.

Just a quick clarification, but you don't see that the biotech CRO market has got more competitive in last, say, 6 months or so? We have heard about some of the large peers investing in biotech venture funds to help secure some early-stage biotech work.

Just curious if that is having an impact. How do you think about the industry competitive landscape, in particular, for the last 6 or so months?

I I don't know how to I

I just don't know the impact of that. How how would I know?

I don't even know what, funds or what, where where they might be doing. They they talk about being more active, and and certainly, we have it's a very competitive market.

I I haven't seen a a large change there. Certainly, what our our our biggest factor over the last 18 months has been cancellations, but, we're we're, we we think, we do have to work on our win rate.

Is that due to, increasing competitiveness? I I I don't know.

It It's just How do you How do I How do you measure that? I just don't have a way.

Certainly, we we would like to win more.

Fair point. The last one.

Last quarter, you mentioned that in 2026, you don't expect a net productivity benefit from AI, as investments would largely offset the gains. Given the continued advancements and growing interest in AI over the last few months, has there been any impact, any change in your thinking?

How should we think about the potential impact, positive or negative, of AI on your business internally?

I just reiterate what I said before. I think that AI would either have to be so transformative as to just be ending our industry in the short term, or just total hype for us to have savings in the next year or two.

If AI is really something of value, which I believe it is, it's going to take a lot of investment to achieve that saving. Because it's such a attractive area for improving overall process and efficiency, it's going to take a lot of investment.

The only reason we wouldn't do that investment is if we thought there was, "Oh, this is some low-hanging fruit. We'll grab that," but really it's just a lot of hype.

Then you'd see some efficiency. No, I think the next 2 years at least, we're going to be investing more dollars in trying to achieve future benefit than we will gain in terms of efficiency.

I stand by that. I still think it's a few years out before we see any actual net benefit.

Not that we won't see efficiencies, even currently we are, but I think net benefit on it all, I think you're talking about, for us, I think it's a few years out.

Great. Thanks a lot.

Hey, this is Drake on for Luke. Thanks for the question.

I know large pharma isn't a big focus for you, but as they spend ahead of patent cliffs and scoop up more of these biotechs, and assuming the demand is less volatile, when would it make sense to take on more of this work, or will it always make sense to prioritize biotech?

Yeah. Look, we've made a strategic decision not to play in large pharma.

To be there, you need to have very flexible model of delivery involving staffing and quite a bit of functional outsourcing. That's pretty uniform across large pharma.

It's not to say that they don't do some full-service outsourcing, but it's in a very different environment, and they expect their partners, if you're going to be one, to have all of those services. We've chosen not to do that.

We chose not to do that not because it's not an attractive area, it's because we think it does detract from some of our focus on full-service, internal expertise, and driving our own efficient process of clinical development, that I think is of value to many virtual and smaller companies, as opposed to a very large pharma that have a lot of systems and are more focused on how to incorporate their CROs into their system. It is a different model in many ways.

It's not unachievable, but it's something we've decided is not for us.

Great. Thank you.

Thanks. Hi.

Good morning. August, you mentioned in your prepared remarks some initiatives you're putting into place to improve your win rate.

Maybe if you could just tell us a little bit more about what you're doing there and how quick kind of the pull-through on those could be in impacting gross wins?

Yeah. I'm not going to get into individuals thing we're doing.

I think that's just a little bit too much to push out to our competitors. I just wanted to really express that we're all focused on this.

We do see opportunities, I wanted to just point out we do believe there's opportunities to expand both the pipeline and the win rate on our opportunities to really combat the higher cancellations, should they continue on, to get back to a growth rate that we want. It was more to really focus on that.

In terms of timing, I'm hoping over the next few quarters, we're going to see real improvement. I think we already had, even in Q1, we had a good win rate, and so I'm hoping it's sustainable, and the things we've done and put in place and the enhancements we're making improve our win rate meaningfully over the immediate term.

Okay. Then, maybe taking that and just going back to the comments on the revenue outlook.

You continue to hire in the quarter, despite the cancellations and the softer gross wins. Just any more context you can share there that seems to be signaling confidence you will continue to grow revenue, but maybe just some help squaring kind of the declining net wins with the increasing headcount?

Oh, I think you have it right there. That's the confidence.

We're still hiring. I don't know how you get any more confidence than that.

All right. Thanks again.

Morning. Thank you for taking the question.

Maybe to flip the AI question a different way, August. As you engage with clients, do you see any commercial usage of AI being done by your clients right now?

We see day by day, it seems like Anthropic, OpenAI continue to release modules designed to address clinical trial work, drug discovery. Is any of that factoring into the dynamics on what you think could be in play relative to the bookings performance, and the challenges you noted relative to some of the slow down in the quarter?

No, I don't think there's real applications that our clients are using that are impacting our interaction with them. Like everybody's using AI in places, many times embedded in other systems, etc.

I don't think it's anything that's affecting our provision of services or interaction with clients at the current time, no.

Got it. I know you said, Kevin, no buyback in the guidance now, but given the way the stock's reacted to earnings, any thoughts on just capacity and capability, not just from the authorization, but cash flow availability given clearly what's a decent amount of cash on the balance sheet?

Certainly we've got authorization in place. I think we've got a little bit over $800 million in authorization, and we'll continue to execute as we always have, and look for opportunities to do that.

No, we will continue to execute under our planning strategy that we always have.

Thank you.

Morning, thanks for taking the questions. Maybe just going back to SG&A, looked like there was a pretty nice improvement sequentially.

Can you talk a little bit about what drove the improvement, and then just how should we think about SG&A going forward, especially in light of the comments earlier that you're continuing to hire, what are sort of the efficiencies and how should we think about that going forward?

SG&A was up slightly sequentially. Right?

Oh, okay. Do you expect though that, again with sort of the cancellations going forward and maybe in the past, you've talked about having some pretty strong retention of your professionals.

Do you envision more operating efficiencies going forward?

Certainly because of the improved retention rates that we've seen, we continue to see some efficiencies, probably at a slower pace than we have, if you look at guidance in the midpoint of guidance. Our margins to remain in a very good spot.

No, we continue to see some leverage just because of that, as reflected in our guidance.

Got it. Okay.

Then, maybe just trying to take another angle at the cancellations. Not sure if you've commented on this in the past, but do you see within cancellations any trials that are suspended and, maybe are outside of your bookings time horizon, but have the potential to restart in the future?

Oh,

sure. Both things in backlog and things that haven't reached backlog, that's always one of the biggest risks.

Look, there's always total cancellation risk, but one of the biggest risks is timing of it, making it to backlog when it starts proceeding. Sometimes they award something, heck, even before they've raised money to do the trial, well before they're ready to move forward on it, or awarded it as part of a series of studies that are based on each other.

It's sequential. There's always a question whether things get pushed out, or sometimes they can accelerate and come in quicker than we expected.

Generally if something happens, it's they get pushed out, or canceled.

Got it. Okay.

Just to follow up on that. Do you feel there's, I guess, confidence in your outlook in that perhaps some of those cancellations could resume within the year?

If it's a cancel, it's probably dead. Look, things don't generally come back from the cancel bucket.

I'm just saying that there are things that didn't make it into backlog in a given quarter that might come in in future quarters. We might have expected them to come in one quarter, and then they get delayed, and get pushed into other quarters.

Some of the stuff that's in backlog gets put on hold, yeah, it could cancel. We don't cancel it because of that.

We just hold it in backlog. It remains in backlog.

We don't cancel it. It's just on hold for a period of time, and then hopefully, it gets started, or maybe it does cancel in the future.

Got it. That's helpful.

Thanks for taking my questions.

Thanks for the follow-ups, and I am definitely expecting a snarky response on this, cuz it's probably a bad question. I'm curious what level of net book-to-bill you are using internally to help guide the revenue outlook that you do have.

I know calling quarters is incredibly unreasonable, particularly at this point in April. You don't know what the cancels will be at this point.

I get that, but you do have a forecast internally, and I'm just trying to level-set what you're thinking, and where you would be directionally steering those of us on the outside so we don't get ahead of our skates here over the next quarter, next three quarters.

First off, just God, book-to-bill, it's just a horrible measure. Look, I get it.

It's useful to see that the bucket's filling at a rate that's commensurate with what's pouring out in the revenue, that you're either growth or non-growth in future revenue opportunity. Particularly under 606, and you don't model things based on a book-to-bill.

Do we miss book-to-bill because revenue ran up so fast that it made our book-to-bill lower, even though we exceeded on bookings in our expectations? You miss on things that are good.

You missed that book-to-bill target because our revenue was so high. Oh, is that a bad thing?

It's a flawed measure of performance. It's a great measure to see if the bucket's filling versus emptying.

They're different buckets, unfortunately, under 606, and you don't even know whether the good buckets actually filling, while another bucket's draining. I didn't want to talk about book-to-bill, and I'm not going to give a guide to future book-to-bill for us.

We certainly do hope to have improving bookings over time, and I would assume that the book-to-bill, certainly 0.88 where things are contracting, is not anything we would expect going forward. The cancellations can drive you to lower levels occasionally.

I completely agree with you on the book-to-bill. I wish you could see my correspondence with investors on this topic.

I'm 100% on board, but bookings dollars are important, and I was really hoping more for direction on that. You just did 618 in the quarter.

Internally, are you modeling 650, 700? I'm just trying to get a sense on what you're thinking the dollars will be.

Forget the ratio. What you need to do to be within this revenue guidance range for the year.

We do anticipate that it will increase, but I don't want to quantify anything there. We're not going to guide to bookings in given quarters, and it's just too variable.

I do anticipate it to increase, but there's no guarantees on anything.

Fair enough. Then on the pre-backlog, in the past, you've given some ballparks on that, and I think at one or two times Well, quantification,

you mean in terms of cancellations in there, or do you mean in terms of magnitude?

No, just the size of the pre-backlog. The stuff that's won, but it hasn't moved into the 3-year window yet.

All right, in response to kind of the moving parts and how we could have growth, and I said that it was comparable size to backlog itself. Actually somewhat larger at the time, I'd said.

We've never tried to quantify that, and again, it's because it's so variable. It's a size that is generally comparable to backlog.

Yeah. Okay.

Fair enough. Thank you very much.

Hi, good morning, everyone. August, I'm just trying to understand some of the moving parts here on the gross versus net.

I think folks are a little confused on what we're seeing in the broader macro environment, and biotech funding, and that's largely your customer base. Then, in terms of the bookings that we see now, it seems like, realistically, if you take a step back, you guys have grown net bookings 25% year-over-year.

You could say you might be a little bit of a victim of your own success because of the outsized growth that you've had over the last year-plus versus the rest of the industry. You're calling out cancellations as well.

What about the overall gross environment? Was this an RFP sort of dynamic that you saw, a win rate dynamic?

It seems like your win rates were okay or actually stepping up. Was it just the opportunities weren't there in the quarter or something else?

Can you help us understand that?

Sure. Maybe there's a little confusion over where things happened.

In the current quarter, as I said, our awards were good, and our win rate was good, okay? If we had a backlog policy that shows anything that we get awarded in a quarter as going into backlog, as some CROs have done in the past, we would have had a good book-to-bill.

I don't know what it would have been, but it would have been, I think people would be happy with it. We don't because those awards are often just based upon future plans, and there's a lot to be done, and like I said, they might not even have money.

In our client base, it's not like a large pharma that hands over to one of their partners a protocol on a study for a compound that they're ready to run with. Sometimes there's a lot of moving parts with our clients, and they award us something, and it can be quite a while before it starts, and there's quite a bit of risk that it never gets there, that never gets to start.

We don't recognize that into a backlog, which are things that are ongoing, okay? That's stuff that we start up.

That's our backlog. It's the future opportunity for projects that have started.

We have a lot of projects that are not started and may never start in this kind of pre-backlog. The quarter was good in terms of clients telling us that they've now got money or they've got plans, or they're going to have money, and they want to use us.

What is actually starting in the quarter is based on stuff that was awarded to us in prior quarters. I don't know, could have been some of them, 2 years ago.

Some of it, last quarter, the quarter before, whatever. There is a little bit of a disconnect between current environment and our bookings.

Current environment is a better reflector on our bookings I don't know, 2, 3 quarters out or so. There's a lag.

Does that answer the question?

That's helpful. Then maybe to just bridge that a little bit, it does sound like sort of awards or wins were good, but that's not starting anytime soon.

Then, if we sort of zoom back to what Eric asked, the pre-backlog, then, is that growing or has that been

Yes. Pre-backlog did grow.

We're just not going to give metrics on the size of the growth. I just, one time, said because there was this huge cliff people thought was happening, which I, like I say, I can't, at this point, it's a greater risk than it was back then, because cancellations have been so large.

I'd said I think that pre-backlog had grown by 30% or something. We're not going to give percentage growth in pre-backlog.

Yes, like I said, we had a good quarter in terms of new authorizations, not into backlog, but just they're telling us they plan to use us in the future. If you add up all those, the pool grew in the quarter.

Okay. That's helpful.

Then just last one for me, in terms of those authorizations, is there a way, or how do you sort of risk-assess or risk-adjust quality of those awards? Is there any change in the trend that you're seeing, between now and over the last few months?

Or a few quarters?

You're asking how we assess for modeling backlog conversion and conversion into backlog and future revenue? How do we assess that risk?

Is that what you're asking about?

That, and let's say how well capitalized or funded these programs are.

That's part of the assessment of the likelihood of moving forward. All right, we do make an assessment of when we think something will progress based on a number of factors, but I don't have a track.

We don't track how many are in this bucket versus how many in that bucket, and which ones are high risk versus low risk. I don't have any of those kind of metrics.

We do, on a project-by-project basis, estimate risk-adjust, probability-adjust opportunities. Things in pre-backlog schedule when we think they're going to make it to backlog and when we'd realize revenue from them.

We do have the planning tools for making a model around our bookings and our revenue. That is true, but I don't have whether there's been an increase in the number of projects that are in this category of very high risk and don't even think about it kind of stuff.

I don't have any of that.

Okay. Thank you for the questions.

Hi, thanks for taking the follow-up. At the risk of belaboring, I was going to come back for one more.

August, we've talked in some detail around your bookings policy and the cadence of award, and I still struggle to, I think, evangelize some of those things, I'm going to say some things, and I'm hoping you'll confirm them. Number one, you've talked about on this call an award to a booking could be as short as 1 to 2 quarters or as long as a couple years.

You've said to me in the past, the inside range is maybe 3 to 5 quarters, call it about a 4-quarter average from award to booking recognition. Do you agree with that?

I don't have in front of me the metrics, but that's kind of in the ballpark, yeah.

Okay. Then, for clarity, when you recognize a booking, I think we've talked in the past, and you've kind of alluded to this on public calls in the past, that a booking for you is basically happening coincident with first patient in.

Do you agree with that?

Yes, that's true.

Okay. The audience understands, then, at that point, you have already, not you, but the company, Medpace, has already done a fairly significant amount of setup work on the trial that is rev rec-able, correct, at the time you're recognizing the booking?

That's frequently the case, yes.

Yes, okay. In the case of Yeah, sorry.

Is that somebody wants to chime in, or is that me? I'm hearing an echo.

Sorry. In the case of a cancellation where the client decides not to move forward, I guess I would interpret that doesn't really happen because they already have.

Is that right?

No, it's not infrequent that somebody pulls the plug before we get to first patient in. The costs are very small compared to launching a trial.

Things do cancel at any stage right up to once patients are in, then it's usually it has to be something big, a toxicity or something, failure of the compound, something. Once you've invested that, it's generally you don't pull patients off of the drug just.

Before patients in, it's much higher risk. You're right, we generally have though very limited some LOI, some start-up pass order that is covering the costs that might be going before the study fully launches.

Sometimes we have a contract, but very often we have something covering us and limits their amount of liability to some X number of dollars, and they could pull the plug. Sure.

Right. Right.

In that case where the client is deciding to pull the plug before first patient in, more times than not, that's a pre-backlog cancellation, not a backlog cancellation, right? Because they haven't gotten

Yeah, virtually always. No, if you're talking about just backlog, yes, that's they've expended quite a bit of resources.

When it gets to the point where the quarter in which it goes into backlog, they've expended a lot of resources, and that's highly unlikely to cancel. I'm just saying that 3 quarters before first patient in, the amount of work we might have done, some work in terms of some regulatory work and other things, but the investment's relatively small and they can cancel that.

Right, and I understand I'm belaboring the point, but in the case like this quarter where cancellations of backlog were relatively high, and you answered to Eric, it's not just one, it's several, those are trials that have patients in the study that the client has chosen to cancel, and those can happen because of futility of the drug or things like that, but more often I guess I'm asking in this quarter, in this particular case, what does drive the higher cancellation asking in the context of those studies having advanced as far as they have in order for them to have already gotten into backlog?

Generally product failure. Look at oncology, it happens all the time.

It's not working. It's got multiple phases possibly of it, and they're rolling one into the next, etc., or just it just get canceled because there's unexpected toxicity.

It's also some things go really well and you finish early, you recruit faster, and there's a cancellation because the budget was for a 2-year study, or 2 years of recruitment, and you recruit it in 1 year, client gets money back. The contract amount is reduced.

There's lots of ways in which the total budget might wind up being less than what you bid it at and put in backlog. Right.

Got it. My last question for you on a completely different subject, and congrats to Jesse on the retirement.

August, I know this has been a lot of your life for a very long period of time, but what is your commitment to the company? How do you view your own longevity in your current role?

How do I view my longevity? Look, I don't know.

Look, I'm committed to the company. I'm obviously very passionately interested in Medpace and its success.

I'm going to be here for quite a while, and I will retake duties as President, as I had in the past, and I don't think there should be any kind of disruption or problem. We do have a very strong and deep management team, and we will eventually have someone move to that spot, but it's not in the near term.

We do have plenty of management strength to continue to move Medpace forward.

Got it. Thank you for enduring my many additional questions.

Thanks very much.

No, thanks. I think our hour is up.

I don't know where we are in the queue.

Good.

Yes, thank you for joining us on today's call and for your interest in Medpace. We look forward to speaking with you again on our second quarter 2026 earnings call.