- Business
- Aeolus Pharmaceuticals, Inc. is a biopharmaceutical company headquartered in Mission Viejo, California, founded in 1996. The company develops a platform of novel compounds primarily for use in biodefense, fibrosis, oncology, infectious diseases, and diseases of the central nervous system. Its core products include AEOL 10150, a catalytic antioxidant under development as a medical countermeasure against pulmonary acute radiation syndrome (Lung-ARS) and the delayed effects of acute radiation exposure (DEARE), with additional indications in radiation oncology and idiopathic pulmonary fibrosis. Other compounds include AEOL 11114 for Parkinson's disease and epilepsy treatment and AEOL 20415, an orally available anti-infective agent. Aeolus has licensed approximately 180 compounds from institutions like the University of Colorado, Duke University, and National Jewish Health. Recent developments include process improvements and stability results for AEOL 10150 in a new formulation, as well as the continuation of development efforts supported by U.S. government contracts with the Biomedical Advanced Research and Development Authority (BARDA) and funding from the National Institutes of Health. These contracts focus on FDA approval pathways, such as pre-Emergency Use Authorization applications, and exploring uses against chemical gas and nerve agent exposure. The company’s strategic focus emphasizes leveraging government contracts to develop its lead compounds and expand indications. Aeolus Pharmaceuticals operates mainly in the United States and targets government biodefense programs, healthcare providers in oncology and fibrosis treatment, and neurological disorder therapeutics.