Candel Therapeutics, Inc.
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- Candel Therapeutics, Inc. (NASDAQ: CADL) is a clinical-stage biopharmaceutical company that develops off-the-shelf viral immunotherapies designed to elicit individualized, systemic antitumor immune responses to treat solid tumors. The company's lead product candidate, CAN-2409 (adenovirovec), an investigational multimodal biological immunotherapy from its adenovirus platform, is advancing in a completed Phase 3 trial under FDA Special Protocol Assessment for intermediate-to-high-risk localized prostate cancer, where it has received Regenerative Medicine Advanced Therapy and Fast Track designations; ongoing Phase 2 trials in non-small cell lung cancer (NSCLC) and borderline resectable pancreatic ductal adenocarcinoma (PDAC), with Fast Track and Orphan Drug designations for PDAC, respectively; and positive topline overall survival data from Phase 2a trials in both NSCLC and PDAC. CAN-3110, the lead candidate from its herpes simplex virus (HSV) platform, targets recurrent high-grade glioma in a Phase 1b trial. The enLIGHTEN Discovery Platform further supports development of novel HSV-based viral immunotherapies for additional solid tumors through systematic engineering leveraging human biology and advanced analytics. Founded in 2003 and formerly known as Advantagene, Inc. until its name change in November 2020, Candel Therapeutics is headquartered at 117 Kendrick Street, Suite 450, Needham, Massachusetts. In October 2025, the company entered a $130 million term loan facility with Trinity Capital Inc., drawing down $50 million initially to bolster its cash position to $137.2 million pro forma as of September 30, 2025, funding pivotal Phase 3 initiation for CAN-2409 in NSCLC in Q2 2026, BLA preparations for prostate cancer, and pre-commercial activities pending approval. Candel concurrently prioritized its portfolio by focusing internal resources on prostate cancer and NSCLC programs while pursuing externally funded partnerships for CAN-2409 in PDAC, following compelling Phase 2a data and positive regulatory feedback. The company also completed patient enrollment and reported positive pivotal topline Phase 3 data for CAN-2409 in prostate cancer, positioning it for BLA submission.
Company News
Candel Therapeutics to Present at the SITC 2026 Annual Meeting
Candel Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Candel Therapeutics Announces Publication of Phase 2a Trial Data that Demonstrated Prolonged Survival after Systemic Immune Reactivation by Aglatimagene Besadenovec plus Valacyclovir in Patients with Unresectable Stage III/IV NSCLC with an Inadequate Response to ICI
Candel Therapeutics Announces Integrated Clinical and Biomarker Data That Showed Durable Local and Systemic Immune Activation after Aglatimagene Besadenovec in Intermediate-Risk Localized Prostate Cancer
Candel Therapeutics Announces New Data Showing Sustained Immune Remodeling More Than Two Years After Aglatimagene Besadenovec Treatment in Localized Prostate Cancer at ASTRO 2026
Candel Therapeutics: Strong Buy On Aglatimagene Prostate Cancer BLA Filing In Q4
4 Prostate Cancer Drug Stocks to Watch During Awareness Month
Candel Therapeutics Appoints Martine Zimmermann, PharmD, to its Board of Directors
Candel Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Candel Therapeutics to Present at September Investor Conferences
Are Biotech Stocks The 'Comeback Kid' Of 2026? I Say Yes
Candel Therapeutics Reports Second Quarter 2026 Financial Results and Recent Corporate Highlights
Candel Therapeutics Eyes 2026 Prostate Cancer Filing as Lung Study Ramps Up
Candel Therapeutics: Getting Closer, And Building Out More Paths
Candel Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Candel Therapeutics to Present Extended Data from Phase 3 Results of Aglatimagene Besadenovec at ASTRO 2026
Candel Therapeutics to Present at Canaccord Genuity's 46th Annual Growth Conference in Boston
Candel Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)
Candel Therapeutics: An Overlooked Late-Stage Biotech With Real Potential
Candel Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)