Cybin Inc.
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- Cybin Inc. is a clinical-stage neuropsychiatry company that develops proprietary psychedelic-based therapeutics, including tryptamine serotonin receptor agonists, to treat mental health conditions such as major depressive disorder, generalized anxiety disorder and central nervous system disorders; its lead candidates comprise CYB003, a deuterated psilocin analog in Phase 3 trials as an adjunctive treatment for major depressive disorder, CYB004, a deuterated DMT molecule in Phase 2 for generalized anxiety disorder, and CYB005, an early-stage program targeting CNS disorders, supported by proprietary drug discovery platforms, innovative delivery systems and novel formulations with over 100 granted patents and 250 pending applications. The company engineers next-generation therapies based on psilocin, DMT and MDMA scaffolds with enhanced bioavailability alongside facilitation training programs to advance mental health treatments. Founded in 2019 and headquartered in Toronto, Canada, Cybin operates in Canada, the United States, the United Kingdom, the Netherlands and Ireland, targeting patients with unmet needs in neuropsychiatry through intermittent dosing regimens for sustained efficacy. Recently, Cybin completed enrollment in its Phase 2 study of CYB004 for generalized anxiety disorder, reported positive Phase 2 data for CYB003 demonstrating 12-month efficacy in major depressive disorder, received FDA Breakthrough Therapy Designation for CYB003 with supportive four-month durability data, launched the multinational PARADIGM Phase 3 program for CYB003 comprising APPROACH, EMBRACE and EXTEND studies targeting 550 patients, established strategic clinical site partnerships including with Segal Trials, engaged Thermo Fisher Scientific for U.S. manufacturing of CYB003 drug substance and product, partnered with Osmind to leverage its 800-clinic network for commercial preparation, and announced a $175 million registered direct offering to fund clinical milestones. These advancements build on its 2024 accomplishments, including pipeline progression and clinical expertise expansion, positioning the company for potential transformation of the mental health treatment landscape.
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