- Business
- TME Pharma N.V. (Euronext Growth Paris: ALTME) is a clinical-stage biopharmaceutical company that develops novel therapies targeting the tumor microenvironment for the treatment of aggressive cancers, including glioblastoma and pancreatic cancer. The company offers proprietary Spiegelmer-based product candidates, such as NOX-A12, a CXCL12-inhibiting aptamer designed to enhance immunotherapy and radiotherapy efficacy by mobilizing stem cells and disrupting tumor protection barriers; and NOX-E36 (emapticap pegol), an L-RNA aptamer neutralizing CCL2 chemokines for anti-fibrotic effects in cancer and ophthalmic diseases. These therapies work in combination with standard treatments like chemotherapy, radiotherapy, and immune checkpoint inhibitors to weaken tumor defenses and improve therapeutic outcomes; the company employs approximately 12 people and generates minimal revenue from pharmaceutical activities. TME Pharma N.V., founded in 1997 and formerly known as NOXXON Pharma until its name change in July 2022, maintains headquarters at Max-Dohrn-Strasse 8-10 in Berlin, Germany, with operations centered in Europe. In recent developments, the company announced a partnership with aimed analytics in January 2025 to leverage artificial intelligence for drug discovery and optimization; initiated a strategic restructuring under new CEO Diede van den Ouden, appointed in June 2025, including a shift to an outsourcing model; secured €2.6 million in guaranteed financing in December 2024 and additional €500,000 via bond issue in August 2025 to support transactions around NOX-A12 and NOX-E36; and is pursuing spin-outs, asset sales of subsidiary TME Pharma AG, and out-licensing deals by June 2025.