- Business
- Immatics Biotechnologies GmbH, a clinical-stage biopharmaceutical company, develops T cell redirecting immunotherapies targeting solid tumors, including adoptive cell therapies (ACT) such as IMA203 (PRAME-targeted TCR-T) and TCR bispecifics (TCER) like IMA401 (MAGE-A4/8) and IMA402 (PRAME); its proprietary platforms enable discovery of tumor-associated peptides (TUMAPs), HLA-restricted targets, and T cell receptors for precision oncology treatments across more than 50 cancer types, with PRAME as the lead target in melanoma, lung, ovarian, breast, and endometrial cancers. Founded in 2000 and headquartered in Tuebingen, Germany, with additional sites in Munich, Germany, and Houston, Texas, USA, the company operates globally through three sites and approximately 700 employees, focusing on clinical programs in two therapeutic modalities supported by advanced bioinformatics, peptidomics, and immunomonitoring technologies. Recent developments include achievement of clinical proof-of-concept for next-generation TCER pipeline candidates IMA402 and IMA401 in November 2025, advancement of four clinical programs with active patient enrollment, and strategic collaborations such as the September 2023 research and development agreement with Moderna spanning bispecifics, cell therapy, and cancer vaccines; earlier partnerships encompass Editas Medicine (June 2022, gamma delta T cells and gene editing), Bristol Myers Squibb (2015, adoptive cell therapies), and MD Anderson Cancer Center via Immatics US, Inc.