Celyad Oncology S.A. (CYAD.BR) develops allogeneic CAR T-cell therapies targeting NKG2D ligands for the treatment of hematological and solid malignancies. The company offers proprietary platforms including off-the-shelf CAR T products such as CYAD-101 for acute myeloid leukemia and CYAD-02 for colorectal cancer; next-generation CAR T candidates like CYAD-200 series with enhanced persistence and reduced cytokine release syndrome; and supporting technologies for gene editing and manufacturing optimization. Headquartered in Mont-Saint-Guibert, Belgium, and founded in 2007 as a spin-off from the University of Louvain, Celyad Oncology operates primarily in Europe and the United States, focusing on oncology patients through clinical trials and partnerships with academic and biotech entities. In 2024, the company completed a strategic pivot by divesting its cardiovascular business to concentrate exclusively on oncology, rebranding from Celyad SA to Celyad Oncology S.A. to reflect this focus; it also secured €15 million in funding through a convertible bond issuance and announced a collaboration with PolyBioTech for manufacturing scale-up. Recent developments include the initiation of Phase 1 trials for CYAD-2004 in 2025 and expansion of its U.S. clinical footprint via IND filings with the FDA.