Maze Therapeutics, Inc.
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- Maze Therapeutics, Inc. Maze Therapeutics, Inc. (MAZE) is a clinical-stage biopharmaceutical company that harnesses human genetics through its proprietary Compass platform to develop novel small molecule precision medicines for patients with renal, cardiovascular, and related metabolic diseases, including obesity and chronic kidney disease (CKD); the platform identifies and characterizes genetic variants in diseases, links them to underlying biological pathways via variant functionalization, and informs drug discovery, development, and clinical trial design across all phases. Founded in 2018 and headquartered at 171 Oyster Point Blvd., Suite 300, South San Francisco, California, the company advances a pipeline led by two wholly owned programs targeting CKD, which affects approximately 37 million people in the United States: MZE829, an oral small molecule APOL1 inhibitor for APOL1-mediated kidney disease (AKD) estimated to impact over one million individuals, particularly those with focal segmental glomerulosclerosis (FSGS), following positive Phase 1 results in October 2024 showing good tolerability, dose-proportional pharmacokinetics, and no serious adverse events, with a Phase 2 trial initiated in November 2024 and first patient dosing expected in the first quarter of 2025 and proof-of-concept data in the first quarter of 2026; and MZE782, an oral small molecule inhibitor of the solute transporter SLC6A19 for CKD patients inadequately responding to standard therapies, with potential standalone or combination use and applicability to phenylketonuria (PKU), following Phase 1 trial initiation in September 2024 and initial data expected in the second half of 2025, alongside plans for a parallel Phase 2 trial in PKU. The company operates primarily in the United States, focusing on genetically defined patient subsets within common diseases through its end-to-end research tools and methodologies that prioritize protective genetic effects to mimic natural disease modification. Recent developments include an oversubscribed $115 million Series D financing in December 2024 co-led by Frazier Life Sciences and Deep Track Capital with participation from Janus Henderson Investors, Logos Capital, and existing investors including Foresite Capital, to advance MZE829 and MZE782 clinical programs and expand platform capabilities following conversion of prior convertible notes; an initial public offering (IPO) on Nasdaq priced at $16 per share in January 2025 raising approximately $140 million; positive Phase 1 readout for MZE829 and ongoing enrollment in its Phase 2 trial; and Phase 1 initiation for MZE782, positioning Maze to disrupt CKD treatment paradigms beyond current disease management approaches.
Company News
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