- Business
- Mesoblast Limited Mesoblast Limited (ASX:MSB; Nasdaq:MESO) is a biopharmaceutical company that develops and commercializes allogeneic cellular medicines derived from proprietary mesenchymal lineage cells for the treatment of serious inflammatory diseases; its lead product, RYONCIL (remestemcel-L), targets steroid-refractory acute graft versus host disease (SR-aGVHD) in pediatric patients; additional Phase 3 candidates include remestemcel-L for adult SR-aGVHD and biologic-resistant inflammatory bowel disease, REVASCOR (rexlemestrocel-L) for advanced chronic heart failure, and MPC-06-ID for chronic low back pain due to degenerative disc disease. Founded in 2004 and headquartered in Melbourne, Australia, with operations in the United States, Singapore, Japan, Europe, and China, the company maintains industrial-scale manufacturing processes for off-the-shelf, cryopreserved cell therapies supported by a patent portfolio exceeding 1,000 patents extending to 2044. Recent developments include FDA approval of RYONCIL in December 2024 as the first mesenchymal stromal cell therapy for pediatric SR-aGVHD, its commercial launch and availability at leading U.S. pediatric transplant centers, strategic alliances with Tasly Pharmaceutical Group, JCR Pharmaceuticals, and Grünenthal for development and commercialization, and projected gross revenue exceeding US$30 million for the quarter ending December 31, 2025, reflecting over 37% sequential growth driven by expanding RYONCIL adoption.