- Business
- Novartis AG is a Swiss multinational pharmaceutical corporation headquartered in Basel that focuses on the research, development, manufacturing, and marketing of innovative medicines for patients with serious diseases across oncology, immunology, neuroscience, cardiovascular, renal, metabolic, and other therapeutic areas. The company offers a broad portfolio of branded pharmaceuticals including Kisqali (ribociclib) for breast cancer; Entresto (sacubitril/valsartan) for heart failure; Cosentyx (secukinumab) for inflammatory conditions such as psoriasis; Scemblix (asciminib) and Tasigna (nilotinib) for chronic myeloid leukemia; Pluvicto for prostate cancer; Fabhalta (iptacopan) for rare kidney diseases including C3G and IgA nephropathy; Sandostatin (octreotide) and Signifor (pasireotide) for acromegaly and Cushing's disease; Gilenya (fingolimod) and Mayzent (siponimod) for multiple sclerosis; Diovan (valsartan) and Exforge (amlodipine/valsartan) for hypertension; Lucentis (ranibizumab) for eye diseases; Gleevec (imatinib) for oncology; Kymriah (tisagenlecleucel), a CAR-T cell therapy for blood cancers; and radioligand therapies, cell and gene therapies, as well as treatments for infectious diseases like malaria and influenza; it operates globally with a presence in over 100 countries, supported by R&D hubs in Basel, Cambridge, and San Diego. Formed in 1996 through the merger of Ciba-Geigy and Sandoz, Novartis spun off its generics business Sandoz in October 2023 and Alcon eye care in 2019 to sharpen focus on innovative medicines. Recent developments include the October 2025 agreement to acquire Avidity Biosciences for approximately $12 billion to enhance RNA therapeutics for neuromuscular diseases; April 2025 plans for a $23 billion US manufacturing and R&D expansion across 10 facilities including a new radioligand therapy plant in California and a $1.1 billion San Diego research hub; 2025 acquisitions of Anthos Therapeutics and Regulus Therapeutics; partnerships and licensing deals exceeding $17 billion such as with Argo Biopharma for siRNA candidates, Dren Bio for bispecific antibodies, and Ratio Therapeutics for radiotherapeutics; new approvals for Pluvicto in pre-taxane prostate cancer, Vanrafia for IgA nephropathy, and Fabhalta for C3G; and projections for 5-6% compound annual sales growth through 2029-2030 bolstered by these pipeline advancements.