Olema Pharmaceuticals, Inc.
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- Olema Pharmaceuticals Olema Pharmaceuticals, Inc. (Nasdaq: OLMA), a clinical-stage biopharmaceutical company headquartered in San Francisco, California and founded in 2006, discovers, develops and seeks to commercialize targeted therapies for women's cancers, with a primary focus on endocrine-driven breast cancer; its lead product candidate, palazestrant (OP-1250), comprises a proprietary, orally available complete estrogen receptor (ER) antagonist and selective ER degrader (CERAN/SERD) evaluated in multiple Phase 3 OPERA trials for ER+/HER2- metastatic breast cancer, including monotherapy in second- and third-line settings versus fulvestrant or aromatase inhibitors, first-line combination with Novartis' ribociclib (Kisqali), second-line combinations with CDK4/6 inhibitors such as palbociclib and ribociclib, and additional combinations with Pfizer's atirmociclib (CDK4 inhibitor), Roche's alpelisib (PI3K inhibitor for PIK3CA-mutated tumors), and everolimus (mTOR inhibitor); the company additionally advances OP-3136, an orally available small molecule KAT6 inhibitor in Phase 1 for ER+/HER2- metastatic breast cancer, castrate-resistant prostate cancer, and lung cancer. Olema Pharmaceuticals maintains global commercial and marketing rights to palazestrant, with all clinical data and inventions from key trials jointly owned with partners; it targets patients with significant unmet needs in ER+ breast cancer and expands into other solid tumors leveraging expertise in nuclear receptors and resistance mechanisms. Recent developments include a December 2024 clinical trial collaboration and supply agreement with Novartis enabling the pivotal Phase 3 OPERA-02 trial initiation in mid-2025 for palazestrant plus ribociclib in frontline ER+/HER2- metastatic breast cancer, accompanied by a $250 million equity private placement from investors including Adage Capital Partners LP, Bain Capital Life Sciences and Wellington Management; a September 2025 clinical trial agreement with Pfizer to assess palazestrant with atirmociclib in a Phase 1/2 study informing potential frontline pivotal development; and a November 2025 $218.5 million public offering of common stock with full underwriters' option exercise, bolstering resources for OPERA-01, OPERA-02, and OP-3136 advancement.
Olema Pharmaceuticals, Inc. (OLMA) Presents at Goldman Sachs 47th Annual Global Healthcare Conference 2026 Transcript
Olema Oncology Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Olema Oncology Announces Clinical Trial Collaboration and Supply Agreement with Bayer to Evaluate OP-3136 in Combination with NUBEQA® (darolutamide) in Metastatic Castration-Resistant Prostate Cancer
Olema Oncology Announces Encouraging Initial Clinical Data from the Phase 1 Study of OP-3136, a KAT6 Inhibitor, at 2026 ASCO Annual Meeting
Olema Oncology to Participate in Upcoming Investor Conferences
Olema Oncology Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Olema Oncology Appoints Prakash Raman, Ph.D., to Board of Directors
Olema Oncology to Present Initial Clinical Data for OP-3136 at the 2026 ASCO Annual Meeting
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Olema Oncology Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Olema Stock Up 242%, but Does a $122 Million Position Suggest More Upside Potential?
Olema Pharmaceuticals (OLMA) Loses 33.4% in 4 Weeks, Here's Why a Trend Reversal May be Around the Corner
Biotech Stock Up Nearly 300% Draws $68.7 Million Bet as Breast Cancer Drug Targets 2027 Launch
Olema Oncology Reports Fourth Quarter and Full Year 2025 Financial and Operating Results
Olema Pharmaceuticals, Inc. Investigated on Behalf of Investors - Contact the DJS Law Group to Discuss Your Rights – OLMA
Why Is Olema Pharmaceuticals Stock Dropping On Monday?
Olema Oncology Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
Olema Pharmaceuticals, Inc. (OLMA) Presents at Citi's 2026 Virtual Oncology Leadership Summit Transcript
Olema Pharmaceuticals CEO Teases Fall OPERA-01 Readout, Q2 KAT6 Data and CFO/COO Exit