- Business
- Orexo AB (publ) Orexo AB (publ) is a commercial-stage specialty pharmaceutical company that develops and commercializes improved pharmaceuticals and digital therapies addressing unmet needs in opioid use disorder, substance abuse, and mental health using proprietary drug delivery technologies including the AmorphOX powder-based platform; core products comprise Zubsolv (buprenorphine/naloxone sublingual tablet) and Izipry (high-dose naloxone intranasal powder) for opioid use disorder treatment and overdose reversal in the US, alongside digital mental health programs, with partner-led commercialization of other therapies globally. Founded in 1995 and headquartered in Uppsala, Sweden, the company maintains an international footprint with operations in the United States via its wholly owned subsidiary Orexo US, Inc. in Morristown, New Jersey, and collaborations worldwide targeting patients, caregivers, healthcare professionals, and first responders. In September 2025, Orexo US secured USD 8 million initial funding from the US Biomedical Advanced Research and Development Authority (BARDA) under a potential USD 50.9 million contract to advance OX390, an investigational intranasal AmorphOX-based rescue medication for adulterated opioid overdose-induced respiratory depression.