Chugai Pharmaceutical Co., Ltd.
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- Chugai Pharmaceutical Co., Ltd. (4519.T) is a research-oriented pharmaceutical company that develops, manufactures, markets, imports and exports prescription pharmaceuticals, with a primary focus on oncology, immunology, neurology, nephrology, ophthalmology and other specialty areas; its core products include oncology therapies such as Alecensa (alectinib, ALK inhibitor), Avastin (bevacizumab, anti-VEGF humanized monoclonal antibody), Herceptin (trastuzumab, anti-HER2 humanized monoclonal antibody), Kadcyla (trastuzumab emtansine, anti-HER2 antibody-tubulin polymerization inhibitor conjugate), Lunsumio (mosunetuzumab, anti-CD20/CD3 humanized bispecific antibody), Perjeta (pertuzumab, anti-HER2 humanized monoclonal antibody), Phesgo (pertuzumab, trastuzumab and vorhyaluronidase alfa combination), Polivy (polatuzumab vedotin, antimicrotubule binding anti-CD79b monoclonal antibody) and Tecentriq (atezolizumab, anti-PD-L1 humanized monoclonal antibody), as well as FoundationOne CDx and FoundationOne Liquid CDx cancer genomic profiles; in specialty areas, key offerings comprise Actemra (tocilizumab, humanized anti-human IL-6 receptor monoclonal antibody), Enspryng (satralizumab, pH-dependent binding humanized anti-IL-6 receptor monoclonal antibody), Hemlibra (emicizumab, anti-coagulation factor IXa/X humanized bispecific monoclonal antibody), PiaSky (crovalimab, pH-dependent binding humanized anti-complement C5 monoclonal antibody), Vabysmo (faricimab, anti-VEGF/anti-Ang-2 bispecific antibody), Evrysdi (risdiplam, spinal muscular atrophy agent), Mircera (epoetin beta pegol, long-acting erythropoiesis-stimulating agent) and Tamiflu (oseltamivir, anti-influenza agent), among others like CellCept (mycophenolate mofetil, immunosuppressant) and Edirol (eldecalcitol, osteoporosis agent). Founded on March 10, 1925 and formally established in 1943, Chugai is headquartered at 1-1 Nihonbashi-Muromachi 2-chome, Nihonbashi Mitsui Tower, Chuo-ku, Tokyo, Japan, and operates primarily in Japan with international presence through subsidiaries including Chugai Pharma Europe in London, UK, and Chugai Pharma China Co., Ltd. in China; it is a majority-owned subsidiary of Roche Holding Ltd., which holds approximately 61% ownership. Recent major developments include a October 2025 collaboration and license agreement with Rani Therapeutics for oral delivery technology featuring a $10 million upfront payment, potential milestones up to $175 million and single-digit royalties, building on a prior August 2024 research pact; in late October 2025, Chugai announced the acquisition of Renalys Pharma, Inc. as a wholly-owned subsidiary by late November 2025 for a closing payment of 15 billion JPY plus up to 16 billion JPY in regulatory milestones and sales-linked considerations to secure exclusive development and commercialization rights for sparsentan (FILSPARI) targeting IgA nephropathy in Japan, South Korea and Taiwan; this is followed by a planned absorption-type merger with Renalys Pharma effective December 29, 2025, to streamline operations and accelerate sparsentan development alongside Chugai's existing IgA nephropathy asset sefaxersen (RG6299).
Company News
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