- Business
- Exagen Inc. is a commercial-stage life sciences company specializing in autoimmune disease diagnostics, headquartered in Vista, California, and founded in 2002. The company develops and markets a comprehensive portfolio of proprietary diagnostic tests primarily for rheumatologists and other physicians to aid in the diagnosis, prognosis, and management of autoimmune connective tissue diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and vasculitis. Its core product line is the AVISE® portfolio, featuring nine key tests such as AVISE® CTD, a blood test that integrates cell-bound complement activation products (CB-CAPs) with traditional biomarkers to improve diagnostic accuracy for connective tissue diseases; AVISE® SLE for lupus diagnosis; AVISE® MTX for methotrexate drug level monitoring; and AVISE® Vasculitis to distinguish forms of vasculitis. The company also offers biomarkers for seronegative rheumatoid arthritis, including anti-PAD4 and anti-RA33, which are unique in the commercial market. Exagen's products combine proprietary serology, cell-based assays, algorithmic interpretation, and biomarker innovation to support earlier and more precise autoimmune disease diagnosis and treatment optimization.
Recent major developments include the commercial launch of new biomarkers for seronegative rheumatoid arthritis (anti-PAD4), contributing to expanded revenue. In 2024 and 2025, Exagen secured incremental price increases for its AVISE® CTD test, raising the average selling price to over $400 per test, facilitated by successful reimbursement negotiations. The company closed a $20.2 million public offering in early 2025 and arranged a $25 million credit facility with Perceptive Advisors to refinance existing debt and support growth beyond financial and operational challenges. Exagen also advanced research dissemination by presenting multiple abstracts at major rheumatology conferences, underscoring ongoing investment in diagnostic innovation and personalized medicine for autoimmune diseases. The company projects full-year 2025 revenue between $65 million and $70 million with anticipated positive adjusted EBITDA by Q4 2025 and a path to sustainable free cash flow in 2026. Geographic operations focus primarily on the U.S. market with strategic expansion targeting approximately 5,000 rheumatologists nationwide.
Exagen operates a CLIA-certified laboratory, supporting advanced autoimmune diagnostic testing with stringent quality control processes. The company markets its tests directly through a dedicated sales force and collaborates with healthcare and biopharma partners. It holds patents for key technologies like CB-CAPs and T cell markers and is considered a pioneer in the clinical validation of novel biomarkers for autoimmune diseases. Exagen’s business model leverages scientific innovation, clinical evidence, and commercial execution to serve rheumatologists and patients globally, positioning the company as a significant participant in precision diagnostics for complex autoimmune disorders.
Exagen Inc. is publicly traded on NASDAQ under the ticker XGN. It continues to expand its diagnostic product line and clinical validation efforts while focusing on revenue growth, reimbursement optimization, and operational efficiency to achieve profitability and long-term value creation for shareholders.